Results 21 to 30 of about 34,614 (273)

Targeting and function of the mitochondrial fission factor GDAP1 are dependent on its tail-anchor. [PDF]

PLoS ONE, 2009
Proteins controlling mitochondrial dynamics are often targeted to and anchored into the mitochondrial outer membrane (MOM) by their carboxyl-terminal tail-anchor domain (TA). However, it is not known whether the TA modulates protein function.
Niemann Axel, Rüegg, Marcel, Wagner Konstanze M., Suter Ueli, Rüegg Marcel, Marcel Rüegg, Niemann, Axel, Konstanze M Wagner, Wagner, Konstanze M., Konstanze M. Wagner, Suter, Ueli, Axel Niemann, Ueli Suter   +12 more
core   +7 more sources

Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission [PDF]

Journal of Pharmacological Sciences, 2023
Differentiation-inducing factor 1 (DIF-1) is a morphogen produced by Dictyostelium discoideum that inhibits the proliferation and migration of both D. discoideum and most mammalian cells.
Takeru Inoue, Koichi Miura, Ruzhe Han, Fumi Seto-Tetsuo, Masaki Arioka, Kazunobu Igawa, Katsuhiko Tomooka, Toshiyuki Sasaguri   +7 more
doaj   +2 more sources

Mitochondrial Fission Factor Gene Mutation: A Dilemma for Prenatal Diagnosis.

Int J Appl Basic Med Res, 2021
Mitochondrial fission factor (MFF) gene mutations are rare mitochondrial fission disorders, resulting in autosomal recessive neurological disorders. We here report a rare case of MFF gene mutation running in a family which ultimately turned out to be a variant of unknown significance. A 29-year-old multigravida visited at 18-week gestation for prenatal
Sharma C, Saini A, Gothwal M, Jhirwal M, Patwa P.   +4 more
europepmc   +4 more sources

Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer. [PDF]

EBioMedicine, 2019
Mitochondrial functions are exploited in cancer and provide a validated therapeutic target. However, how this process is regulated has remained mostly elusive and the identification of new pathways that control mitochondrial integrity in cancer is an urgent priority.We studied clinically-annotated patient series of primary and metastatic prostate ...
Seo JH, Agarwal E, Chae YC, Lee YG, Garlick DS, Storaci AM, Ferrero S, Gaudioso G, Gianelli U, Vaira V, Altieri DC.   +10 more
europepmc   +7 more sources

Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission [PDF]

iScience
Summary: Mitochondrial dynamics is a process that balances fusion and fission events, the latter providing a mechanism for segregating dysfunctional mitochondria. Fission is controlled by the mitochondrial membrane potential (ΔΨm), optic atrophy 1 (OPA1)
Charlène Lhuissier, Valérie Desquiret-Dumas, Anaïs Girona, Jennifer Alban, Justine Faure, Julien Cassereau, Philippe Codron, Guy Lenaers, Olivier R. Baris, Naïg Gueguen, Arnaud Chevrollier   +10 more
doaj   +2 more sources

Mitochondrial fission factor promotes cisplatin resistancein hepatocellular carcinoma. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2022
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and one of the leading causes of cancer-related death worldwide. Chemotherapeutic agents/regimens such as cisplatin (DDP) are frequently used for advanced HCC treatment. However, drug resistance remains a major hindrance and the underline mechanisms are not fully understood.
Li X, Wu Q, Ma F, Zhang X, Cai L, Yang X.   +5 more
europepmc   +4 more sources

Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation.

Biochim Biophys Acta Mol Cell Res, 2020
Abstract Peroxisomes are highly dynamic subcellular compartments with important functions in lipid and ROS metabolism. Impaired peroxisomal function can lead to severe metabolic disorders with developmental defects and neurological abnormalities.
Passmore JB, Carmichael RE, Schrader TA, Godinho LF, Ferdinandusse S, Lismont C, Wang Y, Hacker C, Islinger M, Fransen M, Richards DM, Freisinger P, Schrader M.   +12 more
europepmc   +6 more sources

Srv2 Is a Pro-fission Factor that Modulates Yeast Mitochondrial Morphology and Respiration by Regulating Actin Assembly [PDF]

iScience, 2019
Summary: Dynamic processes such as fusion, fission, and trafficking are important in the regulation of cellular organelles, with an abundant literature focused on mitochondria.
Ying-Chieh Chen, Tzu-Hao Cheng, Wei-Ling Lin, Chang-Lin Chen, Wei Yuan Yang, Craig Blackstone, Chuang-Rung Chang   +6 more
doaj   +3 more sources

Mitochondrial fission factor: a living way for mitochondria sensing food. [PDF]

MedComm (2020)
Zhi M, Cao R, Fu X, Li L.
europepmc   +4 more sources

Clinical and Biochemical Features in a Patient With Mitochondrial Fission Factor Gene Alteration. [PDF]

Front Genet, 2018
Mitochondrial Fission Factor (MFF) is part of a protein complex that promotes mitochondria and peroxisome fission. Hitherto, only 5 patients have been reported harboring mutations in MFF, all of them with the clinical features of a very early onset Leigh-like encephalopathy. We report on an 11-year-old boy with epileptic encephalopathy.
Nasca A, Nardecchia F, Commone A, Semeraro M, Legati A, Garavaglia B, Ghezzi D, Leuzzi V.   +7 more
europepmc   +5 more sources