Results 21 to 30 of about 34,022 (144)

Clinical and Biochemical Features in a Patient With Mitochondrial Fission Factor Gene Alteration. [PDF]

Front Genet, 2018
Mitochondrial Fission Factor (MFF) is part of a protein complex that promotes mitochondria and peroxisome fission. Hitherto, only 5 patients have been reported harboring mutations in MFF, all of them with the clinical features of a very early onset Leigh-like encephalopathy. We report on an 11-year-old boy with epileptic encephalopathy.
Nasca A, Nardecchia F, Commone A, Semeraro M, Legati A, Garavaglia B, Ghezzi D, Leuzzi V.   +7 more
europepmc   +5 more sources

Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1. [PDF]

Life Sci Alliance, 2023
In cells, mitochondria undergo constant fusion and fission. An essential factor for fission is the mammalian dynamin-related protein 1 (Drp1). Dysregulation of Drp1 is associated with neurodegenerative diseases including Parkinson’s, cardiovascular diseases and cancer, making Drp1 a pivotal biomarker for monitoring mitochondrial status and potential ...
Froehlich T, Jenner A, Cavarischia-Rega C, Fagbadebo FO, Lurz Y, Frecot DI, Kaiser PD, Nueske S, Scholz AM, Schäffer E, Garcia-Saez AJ, Macek B, Rothbauer U.   +12 more
europepmc   +5 more sources

microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor. [PDF]

BMB Rep, 2017
Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated.
Lee H, Tak H, Park SJ, Jo YK, Cho DH, Lee EK.   +5 more
europepmc   +5 more sources

Mitochondrial Fission Factor (MFF) Inhibits Mitochondrial Metabolism and Reduces Breast Cancer Stem Cell (CSC) Activity. [PDF]

Front Oncol, 2020
Elevated mitochondrial biogenesis and metabolism represent key features of breast cancer stem cells (CSCs), whose propagation is conducive to disease onset and progression. Therefore, interfering with mitochondria biology and function may be regarded as a useful approach to eradicate CSCs.
Sánchez-Alvarez R, De Francesco EM, Fiorillo M, Sotgia F, Lisanti MP.   +4 more
europepmc   +8 more sources

Mitochondrial fission factor drives an actionable metabolic vulnerability in multiple myeloma. [PDF]

Haematologica
Proliferating multiple myeloma (MM) cells in the bone marrow fluctuate across various metabolic states to resist cancer treatments. Herein, we investigate how mitochondrial dynamics, which controls mitochondrial fitness via coordinated fission and fusion events, shapes MM cell metabolism impacting growth, survival and drug sensitivity. We identify MFF (
Cantafio MEG, Valentino I, Torcasio R, Ganino L, Veneziano C, Murfone P, Mesuraca M, Perrotta I, Tallarigo F, Agosti V, De Marco C, Pasqua T, Giallongo C, Cappello AR, Fiorillo M, Gentile M, Tibullo D, Viglietto G, Neri A, Amodio N.   +19 more
europepmc   +4 more sources

Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff). [PDF]

PLoS One, 2019
The mitochondrial outer membrane protein Mitochondrial Fission Factor (Mff) plays a key role in both physiological and pathological fission. It is well established that at stressed or functionally impaired mitochondria, PINK1 recruits the ubiquitin ligase Parkin which ubiquitinates Mff and other mitochondrial outer membrane proteins to facilitate the ...
Lee L, Seager R, Nakamura Y, Wilkinson KA, Henley JM.   +4 more
europepmc   +8 more sources

Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. [PDF]

Diabetologia, 2021
Abstract Aims/hypothesis Mitochondria are highly dynamic organelles continuously undergoing fission and fusion, referred to as mitochondrial dynamics, to adapt to nutritional demands. Evidence suggests that impaired mitochondrial dynamics leads to metabolic abnormalities such as non-alcoholic steatohepatitis (NASH ...
Takeichi Y, Miyazawa T, Sakamoto S, Hanada Y, Wang L, Gotoh K, Uchida K, Katsuhara S, Sakamoto R, Ishihara T, Masuda K, Ishihara N, Nomura M, Ogawa Y.   +13 more
europepmc   +4 more sources

miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor [PDF]

Experimental & Molecular Medicine, 2014
Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial dynamics is related to the pathogenesis of several human diseases, its molecular mechanism is not fully elucidated.
Tak, Hyosun, Kim, Jihye, Jayabalan, Aravinth Kumar, Lee, Heejin, Kang, Hoin, Cho, Dong-Hyung, Ohn, Takbum, Nam, Suk Woo, Kim, Wook, Lee, Eun Kyung   +9 more
openaire   +2 more sources

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo. [PDF]

Sci Rep, 2018
AbstractMitochondria form a dynamic network governed by a balance between opposing fission and fusion processes. Because excessive mitochondrial fission correlates with numerous pathologies, including neurodegeneration, the mechanism governing fission has become an attractive therapeutic strategy.
Kornfeld OS, Qvit N, Haileselassie B, Shamloo M, Bernardi P, Mochly-Rosen D.   +5 more
europepmc   +5 more sources

Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins. [PDF]

PLoS ONE, 2011
Mitochondria in mammals are organized into tubular networks that undergo frequent shape change. Mitochondrial fission and fusion are the main components mediating the mitochondrial shape change.
Pinwei Huang, Chad A Galloway, Yisang Yoon   +2 more
doaj   +1 more source