Results 31 to 40 of about 34,614 (273)

Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1. [PDF]

Life Sci Alliance, 2023
In cells, mitochondria undergo constant fusion and fission. An essential factor for fission is the mammalian dynamin-related protein 1 (Drp1). Dysregulation of Drp1 is associated with neurodegenerative diseases including Parkinson’s, cardiovascular diseases and cancer, making Drp1 a pivotal biomarker for monitoring mitochondrial status and potential ...
Froehlich T, Jenner A, Cavarischia-Rega C, Fagbadebo FO, Lurz Y, Frecot DI, Kaiser PD, Nueske S, Scholz AM, Schäffer E, Garcia-Saez AJ, Macek B, Rothbauer U.   +12 more
europepmc   +5 more sources

Vimar Is a Novel Regulator of Mitochondrial Fission through Miro. [PDF]

PLoS Genetics, 2016
As fundamental processes in mitochondrial dynamics, mitochondrial fusion, fission and transport are regulated by several core components, including Miro.
Lianggong Ding, Ye Lei, Yanping Han, Yuhong Li, Xunming Ji, Lei Liu   +5 more
doaj   +2 more sources

Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. [PDF]

Diabetologia, 2021
Abstract Aims/hypothesis Mitochondria are highly dynamic organelles continuously undergoing fission and fusion, referred to as mitochondrial dynamics, to adapt to nutritional demands. Evidence suggests that impaired mitochondrial dynamics leads to metabolic abnormalities such as non-alcoholic steatohepatitis (NASH ...
Takeichi Y, Miyazawa T, Sakamoto S, Hanada Y, Wang L, Gotoh K, Uchida K, Katsuhara S, Sakamoto R, Ishihara T, Masuda K, Ishihara N, Nomura M, Ogawa Y.   +13 more
europepmc   +4 more sources

A dynamical systems model for the total fission rate in Drp1-dependent mitochondrial fission. [PDF]

PLoS Computational Biology
Mitochondrial hyperfission in response to cellular insult is associated with reduced energy production and programmed cell death. Thus, there is a critical need to understand the molecular mechanisms coordinating and regulating the complex process of ...
Anna K Leinheiser, Colleen C Mitchell, Ethan Rooke, Stefan Strack, Chad E Grueter   +4 more
doaj   +2 more sources

microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor. [PDF]

BMB Rep, 2017
Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated.
Lee H, Tak H, Park SJ, Jo YK, Cho DH, Lee EK.   +5 more
europepmc   +5 more sources

miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor [PDF]

Experimental & Molecular Medicine, 2014
Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial dynamics is related to the pathogenesis of several human diseases, its molecular mechanism is not fully elucidated.
Tak, Hyosun, Kim, Jihye, Jayabalan, Aravinth Kumar, Lee, Heejin, Kang, Hoin, Cho, Dong-Hyung, Ohn, Takbum, Nam, Suk Woo, Kim, Wook, Lee, Eun Kyung   +9 more
openaire   +2 more sources

The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease [PDF]

, 2022
Mitochondria have many forms and can change their shape through fusion and fission of the outer and inner membranes, called “mitochondrial dynamics”.
Lingyu Qin, Shuhua Xi, Qin, Lingyu, Xi, Shuhua   +3 more
core   +1 more source

Antisense Oligonucleotide-Mediated Silencing of Mitochondrial Fusion and Fission Factors Modulates Mitochondrial Dynamics and Rescues Mitochondrial Dysfunction

Nucleic Acid Therapeutics, 2022
Mitochondria are highly dynamic organelles that produce ATP and maintain metabolic, catabolic, and redox homeostasis. Mitochondria owe this dynamic nature to their constant fission and fusion—processes that are regulated, in part, by fusion factors (MFN1 and MFN2) and fission factors (DRP1, FIS1, MFF, MIEF1, MIEF2) located on the ...
Daniel A. Garcia, Andrew F. Powers, Thomas A. Bell, Shuling Guo, Mariam Aghajan   +4 more
openaire   +2 more sources

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo. [PDF]

Sci Rep, 2018
AbstractMitochondria form a dynamic network governed by a balance between opposing fission and fusion processes. Because excessive mitochondrial fission correlates with numerous pathologies, including neurodegeneration, the mechanism governing fission has become an attractive therapeutic strategy.
Kornfeld OS, Qvit N, Haileselassie B, Shamloo M, Bernardi P, Mochly-Rosen D.   +5 more
europepmc   +5 more sources

Metabolic consequences of neuronal mitochondrial fission ablation [PDF]

, 2016
Dynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality.
Restelli, Lisa Michelle
core   +1 more source