Results 31 to 40 of about 34,022 (144)
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells [PDF]
Journal of Cell Biology, 2010 The cytoplasmic dynamin-related guanosine triphosphatase Drp1 is recruited to mitochondria and mediates mitochondrial fission. Although the mitochondrial outer membrane (MOM) protein Fis1 is thought to be a Drp1 receptor, this has not been confirmed. To analyze the mechanism of Drp1 recruitment, we manipulated the expression of mitochondrial fission ...
Otera, Hidenori +6 more
openaire +2 more sources
Nucleic Acid Therapeutics, 2022 Mitochondria are highly dynamic organelles that produce ATP and maintain metabolic, catabolic, and redox homeostasis. Mitochondria owe this dynamic nature to their constant fission and fusion—processes that are regulated, in part, by fusion factors (MFN1 and MFN2) and fission factors (DRP1, FIS1, MFF, MIEF1, MIEF2) located on the ...
Daniel A. Garcia +4 more
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Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. [PDF]
PLoS Computational Biology, 2012 Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Marc Thilo Figge +3 more
doaj +1 more source
Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways
Cell Reports, 2023 Summary: Skeletal muscle is highly developed after birth, consisting of glycolytic fast-twitch and oxidative slow-twitch fibers; however, the mechanisms of fiber-type-specific differentiation are poorly understood.
Tatsuki Yasuda +3 more
doaj +1 more source
Neurobiology of Disease, 2009 Mutations in the GDAP1 gene lead to recessively or dominantly inherited peripheral neuropathies (Charcot–Marie–Tooth disease; CMT). Here, we demonstrate that GDAP1 is a mitochondrial fission factor whose activity is dependent on the fission factors Drp1 ...
Axel Niemann +3 more
doaj +1 more source
BMC Cell Biology, 2018 Background Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis.
Sayilaxi Jieensinue +5 more
doaj +1 more source
Encephalopathy due to mutation in mitochondrial fission factor gene
Indian Journal of Child Health, 2020 Mitochondrial fission factor (MFF) is a part of the protein complex that promotes mitochondrial and peroxisome fission. Mitochondria and peroxisome fission are complex processes of vital importance for cell growth and survival. Here, we are presenting a case of 5-year-old boy with spastic diplegic cerebral palsy, global developmental delay, and ...
Ansh Agarwal +3 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2022 High-fat diet (HFD)-induced obesity has become the major risk factor for the development of cardiovascular diseases, but the underlying mechanisms remain poorly understood.
Peiduo Liu +3 more
doaj +1 more source
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications
Redox Biology, 2017 Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is
Susana Rovira-Llopis +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2023 Differentiation-inducing factor 1 (DIF-1) is a morphogen produced by Dictyostelium discoideum that inhibits the proliferation and migration of both D. discoideum and most mammalian cells.
Takeru Inoue +7 more
doaj +1 more source