Results 11 to 20 of about 34,614 (273)

Mitochondrial fission factor (MFF) frameshift variant in Bullmastiffs with mitochondrial fission encephalopathy. [PDF]

Anim Genet, 2022
Familial cerebellar ataxia with hydrocephalus in Bullmastiffs was described almost 40 years ago as a monogenic autosomal recessive trait. We investigated two young Bullmastiffs showing similar clinical signs.
Christen M, Gutierrez-Quintana R, Vandenberghe H, Kaczmarska A, Penderis J, José-López R, Rupp A, Griffiths IR, Jagannathan V, Leeb T.   +9 more
europepmc   +5 more sources

Mitochondrial fission factor (Mff) is required for organization of the mitochondrial sheath in spermatids. [PDF]

Biochim Biophys Acta Gen Subj, 2021
Background: Mitochondrial fission counterbalances fusion to maintain organelle morphology, but its role during development remains poorly characterized.
Varuzhanyan G, Chen H, Rojansky R, Ladinsky MS, McCaffery JM, Chan DC.   +5 more
europepmc   +7 more sources

Mitochondrial Fission Factor (MFF) Inhibits Mitochondrial Metabolism and Reduces Breast Cancer Stem Cell (CSC) Activity. [PDF]

Front Oncol, 2020
Elevated mitochondrial biogenesis and metabolism represent key features of breast cancer stem cells (CSCs), whose propagation is conducive to disease onset and progression.
Sánchez-Alvarez R, De Francesco EM, Fiorillo M, Sotgia F, Lisanti MP.   +4 more
europepmc   +10 more sources

PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor. [PDF]

J Cell Sci, 2022
This is the author accepted manuscript. The final version is available on open access from the Company of Biologists via the DOI in this recordData availability: The research data supporting this publication are provided within this paper, or as ...
Schrader TA, Carmichael RE, Islinger M, Costello JL, Hacker C, Bonekamp NA, Weishaupt JH, Andersen PM, Schrader M.   +8 more
europepmc   +6 more sources

Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. [PDF]

PLoS Computational Biology, 2012
Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Marc Thilo Figge, Andreas S Reichert, Michael Meyer-Hermann, Heinz D Osiewacz   +3 more
doaj   +3 more sources

Mitochondrial fission factor drives an actionable metabolic vulnerability in multiple myeloma. [PDF]

Haematologica
Proliferating multiple myeloma (MM) cells in the bone marrow fluctuate across various metabolic states to resist cancer treatments. Herein, we investigate how mitochondrial dynamics, which controls mitochondrial fitness via coordinated fission and fusion
Cantafio MEG, Valentino I, Torcasio R, Ganino L, Veneziano C, Murfone P, Mesuraca M, Perrotta I, Tallarigo F, Agosti V, De Marco C, Pasqua T, Giallongo C, Cappello AR, Fiorillo M, Gentile M, Tibullo D, Viglietto G, Neri A, Amodio N.   +19 more
europepmc   +6 more sources

Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff). [PDF]

PLoS One, 2019
The mitochondrial outer membrane protein Mitochondrial Fission Factor (Mff) plays a key role in both physiological and pathological fission. It is well established that in stressed or functionally impaired mitochondria the PINK1 recruits the ubiquitin ...
Lee L, Seager R, Nakamura Y, Wilkinson KA, Henley JM.   +4 more
europepmc   +10 more sources

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells [PDF]

Journal of Cell Biology, 2010
The cytoplasmic dynamin-related guanosine triphosphatase Drp1 is recruited to mitochondria and mediates mitochondrial fission. Although the mitochondrial outer membrane (MOM) protein Fis1 is thought to be a Drp1 receptor, this has not been confirmed.
Sadaki Yokota, Richard J. Youle, Katsuyoshi Mihara, Megan M. Cleland, Kiyoko Setoguchi, Hidenori Otera, Chunxin Wang   +6 more
core   +4 more sources

Identification of elongation factor‐2 as a novel regulator of mitochondrial fission [PDF]

Natural Sciences, 2022
Mitochondria continuously undergo morphologically dynamic processes of fusion and fission to maintain their size, shape, amount, and function; yet the precise molecular mechanisms by which mitochondrial dynamics is regulated remain to be fully elucidated.
Jinhwan Kim, Yanfeng Li, Yan Cheng, Xingcong Ren, Yi Zhang, Cheng Ji, Hua Zhu, Yoshinori Takahashi, Xingdong Xiong, Lixiang Gu, Chrispus Ngule, Xiaofang Xiong, Jianxun Song, Xiaoqi Liu, Jin‐Ming Yang   +14 more
doaj   +2 more sources

Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins. [PDF]

PLoS ONE, 2011
Mitochondria in mammals are organized into tubular networks that undergo frequent shape change. Mitochondrial fission and fusion are the main components mediating the mitochondrial shape change.
Pinwei Huang, Chad A Galloway, Yisang Yoon   +2 more
doaj   +3 more sources