Results 1 to 10 of about 33,532 (118)

DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

Redox Biology, 2018
Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential axis of mitochondrial quality control that plays a critical role in the development of cardiac ischemia-reperfusion (IR) injury.
Qinhua Jin, Ruibing Li, Nan Hu, Ting Xin, Pingjun Zhu, Shunying Hu, Sai Ma, Hong Zhu, Jun Ren, Hao Zhou   +9 more
doaj   +3 more sources

TFAM promotes mitochondrial division by increasing mitochondrial Sirt3 [PDF]

Cell Death and Disease
Mitochondrial transcription factor A (TFAM) plays a crucial role in mitochondrial fission beyond its canonical function in mtDNA maintenance. However, how TFAM regulates mitochondrial fission remains only partially understood. Fluorescence microscopy and
Shixian Zhai, Zihong Huang, Zewei Luo, Chunchun An, Lu Gao, Tongsheng Chen   +5 more
doaj   +2 more sources

A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression

Cell Reports, 2021
Summary: Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of mitochondria to daughter cells. If and how this process can actively drive mitotic progression
Evanthia Pangou, Olga Bielska, Lucile Guerber, Stephane Schmucker, Arantxa Agote-Arán, Taozhi Ye, Yongrong Liao, Marta Puig-Gamez, Erwan Grandgirard, Charlotte Kleiss, Yansheng Liu, Emmanuel Compe, Zhirong Zhang, Ruedi Aebersold, Romeo Ricci, Izabela Sumara   +15 more
doaj   +1 more source

TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. [PDF]

PLoS ONE, 2012
Mitochondria are dynamic organelles that change in response to extracellular stimuli. These changes are essential for normal mitochondrial/cellular function and are controlled by a tight balance between two antagonistic pathways that promote fusion and ...
Hironori Takamura, Yoshihisa Koyama, Shinsuke Matsuzaki, Kohei Yamada, Tsuyoshi Hattori, Shingo Miyata, Kana Takemoto, Masaya Tohyama, Taiichi Katayama   +8 more
doaj   +1 more source

TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis

Nature Communications, 2023
Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an important regulator of the thermogenic capacity of brown adipocytes.
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi   +11 more
doaj   +1 more source

New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics

Frontiers in Endocrinology, 2023
As important organelles of energetic and metabolism, changes in the dynamic state of mitochondria affect the homeostasis of cellular metabolism. Mitochondrial dynamics include mitochondrial fusion and mitochondrial fission.
Shengnan Wang, Haiyang Zhao, Suxian Lin, Yang Lv, Yue Lin, Yinai Liu, Renyi Peng, Huanzhi Jin   +7 more
doaj   +1 more source

Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.

PLoS Genetics, 2020
Balanced mitochondrial fission and fusion play an important role in shaping and distributing mitochondria, as well as contributing to mitochondrial homeostasis and adaptation to stress.
Ana Terriente-Felix, Emma L Wilson, Alexander J Whitworth   +2 more
doaj   +1 more source

RETRACTED: Mitochondrial Fission and Mitophagy Reciprocally Orchestrate Cardiac Fibroblasts Activation

Frontiers in Cell and Developmental Biology, 2021
Although mitochondrial fission has been reported to increase proliferative capacity and collagen production, it can also contribute to mitochondrial impairment, which is detrimental to cell survival.
Qing-Yuan Gao, Qing-Yuan Gao, Hai-Feng Zhang, Hai-Feng Zhang, Jun Tao, Zhi-Teng Chen, Zhi-Teng Chen, Chi-Yu Liu, Chi-Yu Liu, Wen-Hao Liu, Wen-Hao Liu, Mao-Xiong Wu, Mao-Xiong Wu, Wen-Yao Yin, Wen-Yao Yin, Guang-Hao Gao, Guang-Hao Gao, Yong Xie, Yong Xie, Ying Yang, Ying Yang, Pin-Ming Liu, Pin-Ming Liu, Jing-Feng Wang, Jing-Feng Wang, Yang-Xin Chen, Yang-Xin Chen   +26 more
doaj   +1 more source

Activation of ERK–Drp1 signaling promotes hypoxia‐induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity

FEBS Open Bio, 2021
Hypoxia is a risk factor for Alzheimer's disease (AD). Besides, mitochondrial fission is increased in response to hypoxia. In this study, we sought to investigate whether hypoxia‐induced mitochondrial fission plays a critical role in regulating amyloid‐β
Yuan Yuan, Jingjiong Chen, Xuhua Ge, Jiangshan Deng, Xiaofeng Xu, Yuwu Zhao, Hongmei Wang   +6 more
doaj   +1 more source

The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury

Biomolecules, 2021
Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study the temporal dynamics of mitochondrial fusion and fission, we observed the alteration of mitochondrial ...
Yunsi Zheng, Anqi Luo, Xiaoquan Liu
doaj   +1 more source