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Retraction: Balancing mitochondrial dynamics via increasing mitochondrial fusion attenuates infarct size and left ventricular dysfunction in rats with cardiac ischemia/reperfusion injury. [PDF]
Clin Sci (Lond)europepmc +1 more source
New insights into mitochondrial fusion [PDF]
FEBS Letters, 2007 Fusion controls mitochondrial morphology and is important for normal mitochondrial function, including roles in respiration, development, and apoptosis. Key components of the mitochondrial fusion machinery have been identified, allowing an initial dissection of its molecular mechanism. Outer and inner membrane fusion events are coordinately coupled but
David C Chan
exaly +4 more sources
Mitochondrial Fusion and Fission in Mammals [PDF]
Annual Review of Cell and Developmental Biology, 2006 Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial fragmentation, and unbalanced fusion leads to mitochondrial elongation.
David C Chan
exaly +5 more sources
Physiological functions of mitochondrial fusion [PDF]
Annals of the New York Academy of Sciences, 2010 In recent years, the dynamic nature of mitochondria has been discovered to be critical for their function. Here we discuss the molecular basis of mitochondrial fusion, its protective role in neurodegeneration, and its importance in cellular function. The mitofusins Mfn1 and Mfn2, GTPases localized to the outer membrane, mediate outer‐membrane fusion ...
Hsiuchen Chen, David C Chan
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Mitochondrial Fusion: The Machineries In and Out [PDF]
Trends in Cell Biology, 2021 Mitochondria are highly dynamic organelles that constantly undergo fission and fusion. Disruption of mitochondrial dynamics undermines their function and causes several human diseases. The fusion of the outer (OMM) and inner mitochondrial membranes (IMM) is mediated by two classes of dynamin-like protein (DLP): mitofusin (MFN)/fuzzy onions 1 (Fzo1) and
Song Gao, Junjie Hu
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Mitochondrial fusion, fission, and mitochondrial toxicity [PDF]
Toxicology, 2017 Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and function, and are increasingly ...
Joel N Meyer, Anthony L Luz
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The molecular mechanism of mitochondrial fusion
Biochimica Et Biophysica Acta - Molecular Cell Research, 2009 This review is focused on mitochondrial membrane fusion, which is a highly conserved process from yeast to human cells. We present observations from both yeast and mammalian cells that have provided insights into the mechanism of mitochondrial fusion and speculate on how the key players, which are dynamin-related GTPases do the work of membrane ...
Suzanne Hoppins, Jodi Nunnari
exaly +3 more sources
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Mitochondrial fission and fusion
Biochemical Society Transactions, 2016Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a great deal of information about mitochondrial fission and fusion; however, still much needs to be understood for the basic molecular mechanisms of these important cellular processes.
Hakjoo, Lee, Yisang, Yoon
openaire +2 more sources
Mitochondrial fission and fusion
Biochemistry (Moscow), 2015Mitochondria are key cellular organelles responsible for many different functions. The molecular biology of mitochondria is continuously subject to comprehensive studies. However, detailed mechanisms of mitochondrial biogenesis are still unclear. Fusion and fission are among the most enigmatic processes connected with mitochondria.
M V, Patrushev +3 more
openaire +2 more sources