Results 271 to 280 of about 256,048 (301)

Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Nature Chemical Biology, 2023
Membrane dynamics are important to the integrity and function of mitochondria. Defective mitochondrial fusion underlies the pathogenesis of multiple diseases. The ability to target fusion highlights the potential to fight life-threatening conditions.
Yingjie Guo, Huan Zhang, Chen Yan, Birong Shen, Yue Zhang, Xiangyang Guo, Sha Sun, Fan Yu, Jiayun Yan, Ronghe Liu, Qianping Zhang, Di Zhang, Haiyang Liu, Yang Liu, Yaoyao Zhang, Wenlei Li, Jiangyu Qin, He Lv, Zhaoxia Wang, Yun Yuan, Jie-Feng Yang, Ya-Ting Zhong, Song Gao, Bing Zhou, Lei Liu, Deling Kong, Xiaojiang Hao, Junjie Hu, Quan Chen   +28 more
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Physiological functions of mitochondrial fusion

Annals of the New York Academy of Sciences, 2010
In recent years, the dynamic nature of mitochondria has been discovered to be critical for their function. Here we discuss the molecular basis of mitochondrial fusion, its protective role in neurodegeneration, and its importance in cellular function. The mitofusins Mfn1 and Mfn2, GTPases localized to the outer membrane, mediate outer‐membrane fusion ...
Chen, Hsiuchen, Chan, David C.
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Mitochondrial Fusion In Vitro

2007
The field of mitochondrial dynamics has received a great deal of attention as a result of a number of studies linking mitochondrial fission and fusion machinery to apoptosis. Specifically, elevated levels of mitochondrial fission or compromised mitochondrial fusion can sensitize cells to apoptotic stimuli.
Shelly L, Meeusen, Jodi, Nunnari
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New Beginnings: Mitochondrial Renewal by Massive Mitochondrial Fusion

Trends in Plant Science, 2017
Massive mitochondrial fusion (MMF) in germinating arabidopsis seeds, together with earlier studies, suggests a significant role for MMF in the life cycle of flowering plants. MMF is likely to facilitate nucleoid transmission, mitochondrial DNA (mtDNA) recombination, and the homogenization of mitochondrial components, thus providing a type of quality ...
Ray J, Rose, David W, McCurdy
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Mitochondrial fusion and inheritance of the mitochondrial genome

Journal of Plant Research, 2010
Although maternal or uniparental inheritance of mitochondrial genomes is a general rule, biparental inheritance is sometimes observed in protists and fungi,including yeasts. In yeast, recombination occurs between the mitochondrial genomes inherited from both parents.Mitochondrial fusion observed in yeast zygotes is thought to set up a space for DNA ...
Hiroyoshi, Takano, Kenta, Onoue, Shigeyuki, Kawano   +2 more
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Mitochondrial Fusion Through Membrane Automata

2014
Studies have shown that malfunctions in mitochondrial processes can be blamed for diseases. However, the mechanism behind these operations is yet not sufficiently clear. In this work we present a novel approach to describe a biomolecular model for mitochondrial fusion using notions from the membrane computing.
Konstantinos, Giannakis, Theodore, Andronikos   +1 more
openaire   +2 more sources

Intersection between Mitochondrial Permeability Pores and Mitochondrial Fusion/Fission

Neurochemical Research, 2007
The goal of this review is to highlight recent developments in the field of mitochondrial membrane processes, which provide new insights into the relation between mitochondrial fission/fusion events and the mitochondrial permeability transition (MPT).
Irina G, Gazaryan, Abraham M, Brown
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Mitochondrial Fusion Intermediates Revealed in Vitro

Science, 2004
The events that occur during the fusion of double-membraned mitochondria are unknown. As an essential step toward determining the mechanism of mitochondrial fusion, we have captured this event in vitro. Mitochondrial outer and inner membrane fusion events were separable and mechanistically distinct, but both required guanosine 5′-triphosphate ...
Shelly, Meeusen, J Michael, McCaffery, Jodi, Nunnari   +2 more
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Does mitochondrial fusion require transmembrane potential?

Biochemistry (Moscow), 2015
Dissipation of transmembrane potential inhibits mitochondrial fusion and thus prevents reintegration of damaged mitochondria into the mitochondrial network. Consequently, damaged mitochondria are removed by autophagy. Does transmembrane potential directly regulate the mitochondrial fusion machinery?
I E, Karavaeva, K V, Shekhireva, F F, Severin, D A, Knorre   +3 more
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Regulation of mitochondrial fusion and division

Trends in Cell Biology, 2007
In many organisms, ranging from yeast to humans, mitochondria fuse and divide to change their morphology in response to a multitude of signals. During the past decade, work using yeast and mammalian cells has identified much of the machinery required for fusion and division, including the dynamin-related GTPases--mitofusins (Fzo1p in yeast) and OPA1 ...
Kara L, Cerveny, Yasushi, Tamura, Zhongyan, Zhang, Robert E, Jensen, Hiromi, Sesaki   +4 more
openaire   +2 more sources