Results 41 to 50 of about 253,295 (285)
Very Rare Complementation between Mitochondria Carrying Different Mitochondrial DNA Mutations Points to Intrinsic Genetic Autonomy of the Organelles in Cultured Human Cells [PDF]
, 2000 In the present work, a large scale investigation was done regarding the capacity of cultured human cell lines (carrying in homoplasmic form either the mitochondrial tRNALys A8344G mutation associated with the myoclonic epilepsy and ragged red fiber ...
Attardi, Giuseppe +3 more
core +1 more source
Redox Biology, 2023 Although metabolic reprogramming during the differentiation of regulatory T cells (Treg cells) has been extensively studied, the molecular switch to alter energy metabolism remains undefined.
Yulai Fang +8 more
doaj +1 more source
OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. [PDF]
, 2012 BackgroundMitochondrial fusion protein mutations are a cause of inherited neuropathies such as Charcot-Marie-Tooth disease and dominant optic atrophy.
Bers, Donald M +10 more
core +2 more sources
Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.
PLoS ONE, 2008 BackgroundThere is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression.Methodology/principal findingsHere, we demonstrate ...
Marc Liesa +8 more
doaj +1 more source
Neurobiology of Disease, 2011 Changes in dynamic properties of mitochondria are increasingly implicated in neurodegenerative diseases, particularly Parkinson's disease (PD). Static changes in mitochondrial morphology, often under acutely toxic conditions, are commonly utilized as ...
Beth Arnold +3 more
doaj +1 more source
Plant mitochondrial fission and fusion
Plant Biotechnology, 2005 Single plant cells have hundreds of mitochondria that move around and change their shape through the processes of fission and fusion. The Arabidopsis genome has genes for two dynamin-related proteins, DRP3A and DRP3B, that are similar to genes involved in mitochondrial fission in yeasts. DRP3A and DRP3B were localized to mitochondrial constricted sites
Shin-Ichi, Arimura, Nobuhiro, Tsutsumi
openaire +3 more sources
Bioenergetic roles of mitochondrial fusion
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016 Mitochondria are bioenergetic hotspots, producing the bulk of ATP by the oxidative phosphorylation process. Mitochondria are also structurally dynamic and undergo coordinated fusion and fission to maintain their function. Recent studies of the mitochondrial fusion machinery have provided new evidence in detailing their role in mitochondrial metabolism.
Ramos, E., Larsson, N., Mourier, A.
openaire +3 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003 Mitochondrial fusion has been observed in a great variety of organisms from yeast to man. It serves to mix and unify the mitochondrial compartment and plays roles in cellular aging, cell development, energy dissipation and mitochondrial DNA inheritance. Large GTPases in the mitochondrial outer membrane, termed Fzo or mitofusins, have been identified as
openaire +2 more sources
Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus
Neurology Research International, 2015 Brain is predominantly susceptible to oxidative stress and mitochondrial dysfunction during hypobaric hypoxia, and therefore undergoes neurodegeneration due to energy crisis.
Khushbu Jain +3 more
doaj +1 more source
The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury
Biomolecules, 2021 Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study the temporal dynamics of mitochondrial fusion and fission, we observed the alteration of mitochondrial ...
Yunsi Zheng, Anqi Luo, Xiaoquan Liu
doaj +1 more source