Results 271 to 280 of about 53,504 (295)
Some of the next articles are maybe not open access.
Mitochondrial fusion and fission in the control of apoptosis
Trends in Cell Biology, 2005Mitochondrial outer membrane permeabilization (MOMP) determines the point-of-no-return of most if not all signal-transduction cascades leading to cell death. It has been postulated that the molecular mechanism leading to MOMP could depend on the activation of the mitochondrial fission machinery mediated by proteins from the dynamin superfamily. However,
Jean-Luc, Perfettini +2 more
openaire +2 more sources
Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases
New England Journal of Medicine, 2013Mitochondria fuse and divide in response to cell demands and environment. Alterations in mitochondrial dynamics underlie various human diseases, including cancer and neurologic and cardiovascular diseases. Defining the alterations may identify potential therapeutic targets.
openaire +2 more sources
Mitochondrial fission and fusion in neurodegenerative diseases:Ca2+ signalling
Molecular and Cellular NeuroscienceNeurodegenerative diseases (NDs) are a group of disorders characterized by the progressive loss of neuronal structure and function. The pathogenesis is intricate and involves a network of interactions among multiple causes and systems. Mitochondria and Ca2+ signaling have long been considered to play important roles in the development of various NDs ...
Xuan, Liu +4 more
openaire +2 more sources
Mitochondrial fission and fusion and their roles in the heart
Journal of Molecular Medicine, 2010Mitochondria are dynamic organelles that usually exist in extensive and interconnected networks that undergo constant remodeling through fission and fusion. These processes are governed by distinct sets of proteins whose mechanism and regulation we are only beginning to fully understand.
Lesley A, Kane, Richard J, Youle
openaire +2 more sources
The Genetics of Mitochondrial Fusion and Fission
2011Mitochondrial research has undergone a true renaissance in the last few years. One can hardly pick up one of the top basic research or clinical research journals without seeing a new discovery about mitochondrial function in cellular/human health and disease. This book describes the most important aspects of mitochondrial function in neurodegeneration.
Eliana Y. L. Chan +2 more
openaire +1 more source
Principles of the mitochondrial fusion and fission cycle in neurons
Journal of Cell Science, 2013Mitochondrial fusion-fission dynamics play a crucial role in many important cell processes. These dynamics control mitochondrial morphology, which in turn influences several important mitochondrial properties including mitochondrial bioenergetics and quality control, and it appears to be affected in several neurodegenerative diseases.
Cagalinec, Michal +7 more
openaire +2 more sources
Mechanisms of Mitochondrial Fusion and Fission
2006We have studied the mechanisms of mitochondrial fusion and fission in S. cerevisiae. Using a proteomics-based approach, we have identified the WD domain protein Caf4p as a Fis1p binding partner that, along with its paralog Mdv1p, functions as a molecular adaptor between Fis1p and Dnm1p.
openaire +1 more source
Mitochondrial fusion and fission after spinal sacord injury in rats
Brain Research, 2013Responsible for orchestrating cellular energy production, mitochondria are central to the maintenance of life and the gatekeepers of cell death. Its morphology is dynamic and controlled by continual and balanced fission and fusion events. In this study, we analyzed the mitochondrial dynamics and functions after spinal cord injury in rats and further to
Yang, Cao +6 more
openaire +2 more sources
Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
Annual Review of Genetics, 2012Mitochondria are dynamic organelles that continually undergo fusion and fission. These opposing processes work in concert to maintain the shape, size, and number of mitochondria and their physiological function. Some of the major molecules mediating mitochondrial fusion and fission in mammals have been discovered, but the underlying molecular ...
openaire +3 more sources