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Mitochondrial Fission and Fusion in Human Diseases
New England Journal of Medicine, 2014no ...
Sanchis-Gomar, F, Derbré, Frédéric
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The FEBS Journal, 2021
Mitochondria form a branched tubular network in many types of cells, depending on a balance between mitochondrial fusion and fission. How mitochondrial fusion and fission are involved in regulating mitochondrial function and cell proliferation is not well understood.
Fenfen Dong +3 more
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Mitochondria form a branched tubular network in many types of cells, depending on a balance between mitochondrial fusion and fission. How mitochondrial fusion and fission are involved in regulating mitochondrial function and cell proliferation is not well understood.
Fenfen Dong +3 more
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Mitochondrial fission and fusion and their roles in the heart
Journal of Molecular Medicine, 2010Mitochondria are dynamic organelles that usually exist in extensive and interconnected networks that undergo constant remodeling through fission and fusion. These processes are governed by distinct sets of proteins whose mechanism and regulation we are only beginning to fully understand.
Lesley A, Kane, Richard J, Youle
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The role of protein acetylation in regulating mitochondrial fusion and fission
Biochemical Society Transactions, 2021The dynamic processes of mitochondrial fusion and fission determine the shape of mitochondria, which can range from individual fragments to a hyperfused network, and influence mitochondrial function. Changes in mitochondrial shape can occur rapidly, allowing mitochondria to adapt to specific cues and changing cellular demands. Here, we will review what
Golam M. Uddin +2 more
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Principles of the mitochondrial fusion and fission cycle in neurons
Journal of Cell Science, 2013Summary Mitochondrial fusion–fission dynamics play a crucial role in many important cell processes. These dynamics control mitochondrial morphology, which in turn influences several important mitochondrial properties including mitochondrial bioenergetics and quality control, and they appear to be affected in several neurodegenerative ...
Cagalinec, Michal +7 more
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Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases
New England Journal of Medicine, 2013Mitochondria fuse and divide in response to cell demands and environment. Alterations in mitochondrial dynamics underlie various human diseases, including cancer and neurologic and cardiovascular diseases. Defining the alterations may identify potential therapeutic targets.
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Mitochondrial fission and fusion machineries
2004Mitochondria are dynamic organelles, often fusing and dividing in response to changes in the cellular environment, during cell division and differentiation and under many other circumstances that affect mitochondrial function. Mitochondrial division is also an integral part of the apoptotic pathway in mammalian cells.
Lorena Griparic +2 more
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Intersection between Mitochondrial Permeability Pores and Mitochondrial Fusion/Fission
Neurochemical Research, 2007The goal of this review is to highlight recent developments in the field of mitochondrial membrane processes, which provide new insights into the relation between mitochondrial fission/fusion events and the mitochondrial permeability transition (MPT).
Irina G, Gazaryan, Abraham M, Brown
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The Genetics of Mitochondrial Fusion and Fission
2011Mitochondrial research has undergone a true renaissance in the last few years. One can hardly pick up one of the top basic research or clinical research journals without seeing a new discovery about mitochondrial function in cellular/human health and disease. This book describes the most important aspects of mitochondrial function in neurodegeneration.
Eliana Y. L. Chan +2 more
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Mitochondrial fission and fusion in neurodegenerative diseases:Ca2+ signalling
Molecular and Cellular NeuroscienceNeurodegenerative diseases (NDs) are a group of disorders characterized by the progressive loss of neuronal structure and function. The pathogenesis is intricate and involves a network of interactions among multiple causes and systems. Mitochondria and Ca2+ signaling have long been considered to play important roles in the development of various NDs ...
Xuan, Liu +4 more
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