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Mitochondrial fission and fusion
Biochemical Society Transactions, 2016Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a great deal of information about mitochondrial fission and fusion; however, still much needs to be understood for the basic molecular mechanisms of these important cellular processes.
Hakjoo, Lee, Yisang, Yoon
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Mitochondrial fission and fusion
Biochemistry (Moscow), 2015Mitochondria are key cellular organelles responsible for many different functions. The molecular biology of mitochondria is continuously subject to comprehensive studies. However, detailed mechanisms of mitochondrial biogenesis are still unclear. Fusion and fission are among the most enigmatic processes connected with mitochondria.
M V, Patrushev +3 more
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Reciprocal Regulation of Mitochondrial Fission and Fusion
Trends in Biochemical Sciences, 2020The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion mediate energy output, production of reactive oxygen species (ROS), and mitochondrial quality control.
Rasha Sabouny, Timothy E. Shutt
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Mitochondrial fusion and fission in cell life and death
Nature Reviews Molecular Cell Biology, 2010Mitochondria are dynamic organelles that constantly fuse and divide. These processes (collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and for the maintenance of mitochondrial functions. The core components of the evolutionarily conserved fusion and fission machineries have now been identified, and mechanistic ...
Benedikt Westermann
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Mitochondrial fusion and fission in the control of apoptosis
Trends in Cell Biology, 2005Mitochondrial outer membrane permeabilization (MOMP) determines the point-of-no-return of most if not all signal-transduction cascades leading to cell death. It has been postulated that the molecular mechanism leading to MOMP could depend on the activation of the mitochondrial fission machinery mediated by proteins from the dynamin superfamily. However,
Jean-Luc, Perfettini +2 more
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Mitochondrial Fission and Fusion in Human Diseases
New England Journal of Medicine, 2014no ...
Sanchis-Gomar, F, Derbré, Frédéric
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Mitochondrial fission and fusion and their roles in the heart
Journal of Molecular Medicine, 2010Mitochondria are dynamic organelles that usually exist in extensive and interconnected networks that undergo constant remodeling through fission and fusion. These processes are governed by distinct sets of proteins whose mechanism and regulation we are only beginning to fully understand.
Lesley A, Kane, Richard J, Youle
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The FEBS Journal, 2021
Mitochondria form a branched tubular network in many types of cells, depending on a balance between mitochondrial fusion and fission. How mitochondrial fusion and fission are involved in regulating mitochondrial function and cell proliferation is not well understood.
Fenfen Dong +3 more
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Mitochondria form a branched tubular network in many types of cells, depending on a balance between mitochondrial fusion and fission. How mitochondrial fusion and fission are involved in regulating mitochondrial function and cell proliferation is not well understood.
Fenfen Dong +3 more
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Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view [PDF]
Biochimica Et Biophysica Acta - Bioenergetics, 2008 The mitochondrial life cycle consists of frequent fusion and fission events. Ample experimental and clinical data demonstrate that inhibition of either fusion or fission results in deterioration of mitochondrial bioenergetics.
Orian Shirihai, Gilad Twig
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Principles of the mitochondrial fusion and fission cycle in neurons
Journal of Cell Science, 2013Summary Mitochondrial fusion–fission dynamics play a crucial role in many important cell processes. These dynamics control mitochondrial morphology, which in turn influences several important mitochondrial properties including mitochondrial bioenergetics and quality control, and they appear to be affected in several neurodegenerative ...
Cagalinec, Michal +7 more
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