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Mitochondrial fusion and fission in cell life and death
Nature Reviews Molecular Cell Biology, 2010Mitochondria are dynamic organelles that constantly fuse and divide. These processes (collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and for the maintenance of mitochondrial functions. The core components of the evolutionarily conserved fusion and fission machineries have now been identified, and mechanistic ...
Benedikt Westermann +1 more
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Mechanisms of Mitochondrial Fusion and Fission [PDF]
, 2006 We have studied the mechanisms of mitochondrial fusion and fission in S. cerevisiae. Using a proteomics-based approach, we have identified the WD domain protein Caf4p as a Fis1p binding partner that, along with its paralog Mdv1p, functions as a molecular adaptor between Fis1p and Dnm1p.
Griffin, Erik Edmund
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Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration
Acta Neuropathologica, 2006Mitochondrial dysfunction is increasingly being recognized as an important factor contributing to the pathogenesis of neurodegenerative disorders. However, at present, the molecular basis underlying the decline in mitochondrial function is not really understood, but recent experimental evidence has shed some light on the pivotal role of mitochondrial ...
Stephan Frank
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Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
Annual Review of Genetics, 2012 Mitochondria are dynamic organelles that continually undergo fusion and fission. These opposing processes work in concert to maintain the shape, size, and number of mitochondria and their physiological function. Some of the major molecules mediating mitochondrial fusion and fission in mammals have been discovered, but the underlying molecular ...
David C. Chan
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Mitochondrial fission and fusion
Biochemical Society Transactions, 2016Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a great deal of information about mitochondrial fission and fusion; however, still much needs to be understood for the basic molecular mechanisms of these important cellular processes.
Hakjoo, Lee, Yisang, Yoon
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Mitochondrial fission and fusion
Biochemistry (Moscow), 2015Mitochondria are key cellular organelles responsible for many different functions. The molecular biology of mitochondria is continuously subject to comprehensive studies. However, detailed mechanisms of mitochondrial biogenesis are still unclear. Fusion and fission are among the most enigmatic processes connected with mitochondria.
M V, Patrushev +3 more
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Reciprocal Regulation of Mitochondrial Fission and Fusion
Trends in Biochemical Sciences, 2020The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion mediate energy output, production of reactive oxygen species (ROS), and mitochondrial quality control.
Rasha Sabouny, Timothy E. Shutt
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Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view
Biochimica Et Biophysica Acta - Bioenergetics, 2008 The mitochondrial life cycle consists of frequent fusion and fission events. Ample experimental and clinical data demonstrate that inhibition of either fusion or fission results in deterioration of mitochondrial bioenergetics.
Gilad Twig, Orian S Shirihai
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Mitochondrial fusion and fission in the control of apoptosis
Trends in Cell Biology, 2005Mitochondrial outer membrane permeabilization (MOMP) determines the point-of-no-return of most if not all signal-transduction cascades leading to cell death. It has been postulated that the molecular mechanism leading to MOMP could depend on the activation of the mitochondrial fission machinery mediated by proteins from the dynamin superfamily. However,
Jean-Luc, Perfettini +2 more
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