Results 111 to 120 of about 76,259 (184)

The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology. [PDF]

, 2017
Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+)
A Quintana, A Raffaello, A Rasola, A Tosatto, A Varadi, AA Rowland, AI Tarasov, AN Antony, AR Marks, B Chance, B Glancy, B Moreau, C Giorgi, C Petrungaro, CC Mendes, CD Lobaton, CV Logan, CV Nicchitta, D Chaudhuri, D Chaudhuri, D De Stefani, D Jiang, D Lewis-Smith, D Tomar, D Vecellio Reane, DA Cox, DD Hall, DG Nicholls, DJ Pagliarini, E Carafoli, E Carafoli, E Kovacs-Bogdan, E Murphy, E Noack, E Rapizzi, F Fieni, F Fieni, F Perocchi, FD Vasington, G Bathori, G Beutner, G Beutner, G Csordas, G Csordas, G Csordas, G Csordas, G Csordas, G Csordas, G Csordas, G Czirjak, G Giannini, G Hajnoczky, G Hajnoczky, G Huang, G Michels, G Munch, G Szabadkai, G Szalai, G Szanda, G Szanda, GA Rutter, GC Sparagna, GD Schellenberg, GL Becker, H Vais, HF Deluca, I Bogeski, I Drago, I Zimanyi, J Matesanz-Isabel, J Nakai, J O-Uchi, J O-Uchi, J O-Uchi, J Qiu, J Santo-Domingo, J Schwartz, JD Martell, JG McCormack, JL Harrington, JM Baughman, JQ Kwong, JS Marchant, JT Lanner, JW Putney Jr, K Mallilankaraman, K Mallilankaraman, K Oxenoid, KJ Kamer, KM Holmstrom, L Buntinas, L Hymel, L Mela, L Wang, LH Jeyakumar, LK Seidlmayer, LS Jouaville, M Boerries, M Crompton, M Crompton, M Giacomello, M Giacomello, M Hoth, M Hoth, M Montero, M Montero, M Murgia, M Patron, M Plovanich, M Salvi, M Sastrasinh, MA Matlib, MF Tsai, MK Park, ML Joiner, ML Joiner, ML Litsky, ML Olson, MR Alam, MR Duchen, N MacQuaide, NE Hoffman, NJ Dolman, P Bernardi, P Koncz, P Pinton, PJ Doonan, PS Brookes, R Amann, R Jakob, R Malli, R Malli, R Perez-Campo, R Rizzuto, R Rizzuto, R Rizzuto, R Rizzuto, RM Denton, RM Denton, RM Denton, RS Sohal, S Feng, S Fuente de la, S Grimm, S Marchi, S Shanmughapriya, S Xu, SA Thayer, SS Lam, SY Ryu, T Pozzan, T Rharass, T Yamamoto, TE Gunter, TE Gunter, TE Gunter, TS Luongo, V Hung, V Paupe, VK Sharma, W Tan, WL Ying, X Pan, X Quan, Y Kirichok, Y Lee, Y Sancak, Y Wu   +167 more
core   +2 more sources

Serofendic Acid Protects Against Myocardial Ischemia–Reperfusion Injury in Rats

Journal of Pharmacological Sciences, 2014
.: We previously reported that serofendic acid, a lipophilic extract of fetal calf serum, protects against oxidative stress in primary culture of neonatal rat cardiomyocytes.
Tadaaki Ioroi, Masaharu Akao, Moritake Iguchi, Masashi Kato, Takeshi Kimura, Yasuhiko Izumi, Akinori Akaike, Toshiaki Kume   +7 more
doaj   +1 more source

K-ATP channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]

, 2002
Background-Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.Methods and Results-We have ...
Chanalaris, A, Comini, L, Ferrari, R, Hubank, M, Knight, RA, Latchman, DS, Lawrence, KM, Pasini, E, Scarabelli, T, Stephanou, A, Tinker, A, Townsend, PA   +11 more
core  

Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs

Medicinal Research Reviews, 2014
AbstractBrief periods of ischemia are known to confer to the myocardium an increased resistance to the injury due to a later and more prolonged ischemic episode. This phenomenon, known as ischemic preconditioning (IPreC), is ensured by different biological mechanisms.
TESTAI, LARA, RAPPOSELLI, SIMONA, MARTELLI, ALMA, BRESCHI, MARIA CRISTINA, CALDERONE, VINCENZO   +4 more
openaire   +3 more sources

Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels

The Journal of Medical Investigation, 2016
Activation of the mitochondrial calcium-activated potassium (mKCa) channel reportedly confers resistance to myocardial ischemic stress. However, the role of the mKCa channel in postconditioning induced by volatile anesthetic remains unclear.Male Japanese white rabbits underwent coronary artery occlusion for 30 min followed by reperfusion for 3 h ...
Michiko, Kinoshita, Yasuo M, Tsutsumi, Kohei, Fukuta, Asuka, Kasai, Katsuya, Tanaka   +4 more
openaire   +3 more sources

Arylthioamides and aryliminothioethers as new slow H2S-releasing agents [PDF]

Hydrogen sulphide (H2S) is emerging as an important endogenous modulator, which exhibits the beneficial effects of nitric oxide (NO) on the cardiovascular (CV) system, without producing toxic metabolites.
ANGELINI, MARIAGRAZIA
core  

Identity and Function of a Cardiac Mitochondrial Small Conductance Ca2+-Activated K+ Channel Splice Variant [PDF]

, 2017
We provide evidence for location and function of a small conductance, Ca2+-activated K+ (SKCa) channel isoform 3 (SK3) in mitochondria (m) of guinea pig, rat and human ventricular myocytes. SKCa agonists protected isolated hearts and mitochondria against
Aldakkak, Mohammed, Camara, Amadou K. S., Kwok, Wai-Meng, Stowe, David F., Yang, MeiYing   +4 more
core   +1 more source

The BKCa (slo) channel regulates the cardiac function of Drosophila

Physiological Reports
The large conductance, calcium, and voltage‐active potassium channels (BKCa) were originally discovered in Drosophila melanogaster as slowpoke (slo). They are extensively characterized in fly models as ion channels for their roles in neurological and ...
Shubha Gururaja Rao, Alexander Lam, Sarah Seeley, Jeniffer Park, Shriya Aruva, Harpreet Singh   +5 more
doaj   +1 more source

Mitochondrial regulation of mitochondrial potassium channels

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2018
Adam Szewczyk, Piotr Koprowski, Bogusz Kulawiak, Piotr Bednarczyk   +3 more
openaire   +1 more source

BK channels are indispensable for endothelial function in small pulmonary arteries

Cell Communication and Signaling
Background Pulmonary hypertension (PH) is a progressive vascular disease that severely compromises quality of life and survival. The pulmonary endothelium plays a pivotal role in vascular homeostasis through complex signalling networks involving ion ...
Divya Guntur, Dusan Jeremic, Reka Csaki, Oleh Myronenko, Valentina Biasin, Dagmar Kolb, Laura Michalick, Wolfgang M. Kuebler, Peter Enyedi, Horst Olschewski, Andrea Olschewski, Chandran Nagaraj   +11 more
doaj   +1 more source