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Mitochondrial potassium channels
IUBMB Life, 2009AbstractMitochondrial potassium channels are believed to contribute to cytoprotection of injured cardiac and neuronal tissues. The following potassium channels have been described in the inner mitochondrial membrane: the ATP‐regulated potassium channel, the large conductance Ca2+‐activated potassium channel, the voltage‐gated Kv1.3 potassium channel ...
Adam Szewczyk +2 more
exaly +3 more sources
Signaling pathways targeting mitochondrial potassium channels
International Journal of Biochemistry and Cell Biology, 2020 In this review, we describe key signaling pathways regulating potassium channels present in the inner mitochondrial membrane. The signaling cascades covered here include phosphorylation, redox reactions, modulation by calcium ions and nucleotides. The following types of potassium channels have been identified in the inner mitochondrial membrane of ...
Adam Szewczyk +2 more
exaly +3 more sources
Guide to the Pharmacology of Mitochondrial Potassium Channels
Handbook of Experimental Pharmacology, 2016This chapter provides a critical overview of the available literature on the pharmacology of mitochondrial potassium channels. In the first part, the reader is introduced to the topic, and eight known protein contributors to the potassium permeability of the inner mitochondrial membrane are presented.
Adam Szewczyk +2 more
exaly +3 more sources
Mitochondrial potassium channels in cell death
Biochemical and Biophysical Research Communications, 2018Mitochondria are intracellular organelles involved in several processes from bioenergetics to cell death. In the latest years, ion channels are arising as new possible targets in controlling several cellular functions. The discovery that several plasma membrane located ion channels have intracellular counterparts, has now implemented this consideration
Vanessa Checchetto +4 more
openaire +3 more sources
Pharmacology of mitochondrial potassium channels: dark side of the field [PDF]
FEBS Letters, 2010 Mitochondrial potassium channels play an important role in cytoprotection. Potassium channels in the inner mitochondrial membrane are modulated by inhibitors and activators (potassium channel openers) previously described for plasma membrane potassium channels.
Adam Szewczyk +2 more
exaly +3 more sources