Results 121 to 130 of about 38,197 (138)

Targeting a mitochondrial potassium channel to fight cancer

Cell Calcium, 2015
Although chemotherapy is able to cure many patients with malignancies, it still also often fails. Therefore, novel approaches and targets for chemotherapeutic treatment of malignancies are urgently required. Recent studies demonstrated the expression of several potassium channels in the inner mitochondrial membrane.
LEANZA, LUIGI, Venturini, E, Kadow, S, Carpinteiro, A, Gulbins, E, Becker, K.a.   +5 more
openaire   +3 more sources

Pathophysiological Role of Mitochondrial Potassium Channels and their Modulation by Drugs

Current Medicinal Chemistry, 2018
Background: Mitochondria play a central role in ATP-generating processes. Indeed, in mammalian tissues, up to 90% of ATP is generated by mitochondria through the process of oxidative phosphorylation; furthermore, mitochondria are involved in multiple signal transduction pathways.
Valentina Citi, Vincenzo Calderone, Alma Martelli   +2 more
exaly   +4 more sources

OPENING OF MITOCHONDRIAL POTASSIUM CHANNELS

Transplantation, 2000
This study was designed to assess the protective effects of the mitochondrial adenosine triphosphate-sensitive potassium channel (KATP) opener diazoxide as an additive to heart preservation solution.Forty isolated isovolumic buffer-perfused rat hearts were divided into four groups.
E, Kevelaitis, A, Oubenaissa, C, Mouas, J, Peynet, P, Menasché   +4 more
openaire   +2 more sources

Mitochondrial Permeability Transition Dynamics: An Indicator of Mitochondrial Potassium Channel Opener

2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 2005
Mitochondrial permeability transition (MPT) is an intracellular event that is closely related to apoptosis and necrosis. However, whether this process underlies the recently reported neuroprotective potency of mitochondrial potassium channel openers applied in vivo remains uncertain.
Fang, Shen, Li-Ping, Wu, Yuan, Lu, Hua-Wei, Liang, Iain, Bruce, Qiang, Xia   +5 more
openaire   +2 more sources

Naringenin as an opener of mitochondrial potassium channels in dermal fibroblasts

Experimental Dermatology, 2019
AbstractFlavonoids belong to a large group of polyphenolic compounds that are widely present in plants. Certain flavonoids, including naringenin, have cytoprotective properties. Although the antioxidant effect has long been thought to be a crucial factor accounting for the cellular effects of flavonoids, mitochondrial channels have emerged recently as ...
Kampa, Rafał, Kicinska, A, Jarmuszkiewicz, W, Pasikowska-Piwko, M, Dolegowska, B, Debowska, R, Szewczyk, A, Bednarczyk, P   +7 more
openaire   +3 more sources

Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection

Archives of Biochemistry and Biophysics, 2003
ATP-sensitive potassium channels allow for the coupling of membrane potential to cellular metabolic status. Two K(ATP) channel subtypes coexist in the myocardium with one subtype located in the sarcolemma membrane and the other in the inner membrane of the mitochondria. The ATP-sensitive potassium channels can be pharmacologically modulated by a family
James D, McCully, Sidney, Levitsky
openaire   +2 more sources

New properties of mitochondrial ATP-regulated potassium channels

Journal of Bioenergetics and Biomembranes, 2008
The ATP-regulated potassium channel is present in the inner membrane of heart mitochondria. In this study, the activity of a single channel was measured after reconstituting the myocardium inner mitochondrial membrane into a planar lipid bilayer. We provide direct evidence of vectorial pH regulation of mitoK(ATP) channels.
Piotr Bednarczyk, Krzysztof Dołowy, Adam Szewczyk   +2 more
openaire   +3 more sources

Physiology of mitochondrial potassium channels

2012
The inner membrane of the ATP-producing organelles of endosymbiotic origin, mitochondria, has long been considered to be poorly permeable to cations and anions, since the strict control of inner mitochondrial membrane permeability is crucial for efficient ATP synthesis.
SZABO', ILDIKO', LEANZA, LUIGI, Gulbins E, Zoratti M.   +3 more
openaire   +1 more source

Mechanistic correlation between mitochondrial permeability transition pores and mitochondrial ATP dependent potassium channels in ischemia reperfusion

Biomedicine and Pharmacotherapy, 2023
Agnieszka Najda, Mohamed M Abdel-Daim, Thakur Gurjeet Singh   +2 more
exaly  

What do we not know about mitochondrial potassium channels?

Biochimica Et Biophysica Acta - Bioenergetics, 2016
Adam Szewczyk, Wieslawa Jarmuszkiewicz, Bogusz Kulawiak   +2 more
exaly