Results 91 to 100 of about 426,171 (247)

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Mitochondrial damage control: delineating the mechanisms of mitochondrial repair

, 2022
Mitochondrial function is essential for our health. The mitochondrial quality control machinery identifies and remedies dysfunctional mitochondria to protect the health of our mitochondrial network.
LOUISE MICHELE UOSELIS (12625174)
core   +1 more source

Proteostasis at the mitochondrial outer membrane: Quality control of mitochondrial protein transport

Protein Science
Abstract Mitochondria are enclosed by a double‐membrane structure composed of the outer and inner membranes, and this architectural organization underlies their diverse cellular functions. In particular, the mitochondrial outer membrane serves as an essential interface between the cytosol and the mitochondrial interior, regulating the
Shunsuke Matsumoto, Suzuka Ono, Toshiya Endo   +2 more
openaire   +2 more sources

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity

, 2023
TIM22 pathway cargos are essential for sustaining mitochondrial homeostasis as an excess of these proteins leads to proteostatic stress and cell death. Yme1 is an inner membrane metalloprotease that regulates protein quality control with chaperone-like ...
D'Silva, Patrick, Waingankar, Tejashree Pradip, Kumar, Abhishek   +2 more
core   +1 more source

Glial-derived mitochondrial signals impact neuronal proteostasis and aging

, 2023
Abstract The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response (UPR MT ), between tissues ...
Bar-Ziv, Raz, Dutta, Naibedya, Hruby, Adam, Sukarto, Edward, Averbukh, Maxim, Alcala, Athena, Henderson, Hope R., Durieux, Jenni, Tronnes, Sarah U., Ahmad, Qazi, Bolas, Theodore, Perez, Joel, Dishart, Julian G., Vega, Matthew, Garcia, Gilberto, Higuchi-Sanabria, Ryo, Dillin, Andrew   +16 more
openaire   +2 more sources

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Aging as an Event of Proteostasis Collapse

, 2011
Aging cells accumulate damaged and misfolded proteins through a functional decline in their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and the development of protein misfolding diseases such as Alzheimer's and ...
Dillin, Andrew, Taylor, Rebecca C., A. Dillin, R. C. Taylor   +3 more
core   +1 more source