Results 101 to 110 of about 426,171 (247)

The mitochondrial intermembrane space – a permanently proteostasis-challenged compartment

Biological Chemistry
Abstract The mitochondrial intermembrane space (IMS) houses proteins essential for redox regulation, protein import, signaling, and energy metabolism. Protein import into the IMS is mediated by dedicated pathways, including the disulfide relay pathway for oxidative folding.
Matthias Weith, Konstantin Weiss, Dylan Stobbe, Jan Riemer   +3 more
openaire   +2 more sources

Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu, Xiyu Zhao, Zheyi Jiang, Chaoliang Wen, Chaoyi Wang, Qiulian Wang, Qiang Huang, Fangren Lan, Shenghui Wu, Junying Li, Congjiao Sun, Huadong Yin, Ning Yang   +12 more
wiley   +1 more source

Age-related immune states and PD-1 blockade: mechanisms and strategies for the elderly

Journal for ImmunoTherapy of Cancer
Aging impairs antitumor immunity and may reduce the efficacy of immune checkpoint inhibitors (ICIs). However, the underlying mechanisms remain unclear. Building on our recent findings, we review three key mechanisms of CD8+ T-cell aging: elevated T-cell ...
Tomonori Yaguchi, Tasuku Honjo, Kenji Chamoto   +2 more
doaj   +1 more source

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

Modulation of the activity of human mitochondrial protease complex ClpXP as potential therapeutic strategy for cancer

, 2023
Mitochondrial chaperones and proteases, crucial for mitochondrial proteostasis, are overexpressed in most tumor types, and are involved in cell metabolic reprogramming that allows evasion of apoptosis and increased survival (1).
Morena Miciaccia, Antonella Cormio, Maria Grazia Perrone, Paola Loguercio Polosa, Antonio Scilimati, Francesca Rizzo, Savina Ferorelli   +6 more
core  

Animal models for investigating post‐stroke cognitive impairment: A neurovascular trafficking perspective

Animal Models and Experimental Medicine, EarlyView.
Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

Redox Biology, 2018
Mitochondria are central organelles to cellular metabolism. Their function relies largely on nuclear-encoded proteins that must be imported from the cytosol, and thus the protein import pathways are important for the maintenance of mitochondrial ...
Svetlana Konovalova, Xiaonan Liu, Pooja Manjunath, Sundar Baral, Nirajan Neupane, Taru Hilander, Yang Yang, Diego Balboa, Mügen Terzioglu, Liliya Euro, Markku Varjosalo, Henna Tyynismaa   +11 more
doaj   +1 more source

Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

, 2018
Cellular proteostasis ismaintained via the coordinated synthesis, maintenance, and breakdown of proteins in the cytosol and organelles. While biogenesis of the mitochondrial membrane complexes that execute oxidative phosphorylation depends on cytoplasmic
Suhm, Tamara,, Peselj, C., Buttner, S., Sabrina Büttner, Büttner, Sabrina,, Dawitz, H., Hanzén, Sarah, Masser, Anna E.,, Dawitz, Hannah,, Peselj, Carlotta,, Nyström, Thomas,, Hannah Dawitz, Suhm, T., Bjorck, M. L., Sarah Hanzén, Andreasson, C., Agata Smialowska, Matevž Ambrožič, Tamara Suhm, Andréasson, Claes,, Hanzén, Sarah,, Peter Brzezinski, Martin Ott, Ambrožič, Matevž,, Nyström, Thomas, Kaimal, J. M., Brzezinski, P., Claes Andréasson, Masser, A. E., Thomas Nyström, Ott, Martin,, Carlotta Peselj, Markus L. Björck, Jayasankar Mohanakrishnan Kaimal, Kaimal, Jayasankar Mohanakrishnan,, Smialowska, A., Anna E. Masser, Ott, M., Ambrozic, M., Smialowska, Agata,, Björck, Markus L.,, Brzezinski, Peter,   +41 more
core   +1 more source

A shining starlet: Nematostella vectensis as a model for developmental, regenerative, and comparative biology

Developmental Dynamics, EarlyView.
Abstract The sea anemone, Nematostella vectensis, has been used as a model organism in developmental biology studies for many years. This estuarine species has the notable capacity to regenerate its full body plan from small pieces throughout life. Nematostella have been described as having a great degree of cellular plasticity.
Patrick A. Lewis, Zachary Horowitz, Michael Shribak, Karen Echeverri   +3 more
wiley   +1 more source