Results 121 to 130 of about 426,171 (247)

Association Between Long‐Term Exposure to Air Pollution and Parkinson's Disease: Administrative Cohort of Older Adults in South Korea

Movement Disorders, EarlyView.
Abstract Background Evidence regarding the association between long‐term exposure to ambient air pollution and Parkinson's disease (PD) remains inconsistent, particularly among older adults in Asian populations. Objective We aimed to examine the association between long‐term exposure to ambient air pollutants and incident PD in a nationwide ...
Jongmin Oh, Jisun Myung, Dong‐Wook Lee, Changwoo Han, Yun‐Chul Hong, Soontae Kim, Yoon‐Hee Kang, Hyun‐Joo Bae, Youn‐Hee Lim   +8 more
wiley   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Geranylgeranylated-SCF FBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function

Full Scans of Western blots from the study 'Geranylgeranylated-SCF FBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function'.
Bhat, S (via Mendeley Data), Bhat, Sameer Ahmed   +1 more
core   +2 more sources

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

UPRmt-regulated mitokines: novel strategies for myocardial injury repair

Frontiers in Cell and Developmental Biology
Cardiac mitochondria generate ATP, via oxidative phosphorylation (OXPHOS) to sustain continuous and forceful myocardial contraction, thereby meeting systemic metabolic demands.
Weinan Gao, Jia Liu, Wenda Zhang, Bin Liu, Luyan Shen   +4 more
doaj   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

HSPE1 deficiency underlies the crosstalk between metabolic dysfunction‐associated steatotic liver disease and age‐related macular degeneration

VIEW, EarlyView.
Rare‐earth ions act as multifunctional modifiers in perovskite solar cells by improving charge transport, suppressing oxygen vacancies, passivating defects, promoting grain growth, and enabling redox‐mediated stabilization. In addition, RE‐doped layers can expand spectral utilization through upconversion and downconversion, thereby enhancing light ...
Jiaqi Meng, Alimire Maihemuti, Yuan Yuan, Chao Chen, Mengchao Zhu, Hao Wang, Furong Zhu, Zhaodi Che, Jia Xiao, Xiangjia Zhu   +9 more
wiley   +1 more source

Das Proteostasis System in Nematoden und Bäckerhefe

, 2016
In this work the chaperone related muscular proteostasis and the failure of cellular proteostasis were addressed. The balanced action of Hsc70 and its cofactors UNC-23 and DNJ-13 was found being crucial for the contribution of Hsc70 to muscle ...
Papsdorf, Katharina
core  

Investigating the Interplay of Mitochondrial Dynamics and Proteostasis during Neuronal Ischemia/Reperfusion Injury using Integrated Imaging and Modeling Approaches

Cerebral ischemia/reperfusion (I/R) injuries, including stroke and cardiac arrest can lead to irreversible neuronal damage and neurological complications.
Fogo, Garrett
core   +1 more source

Zn2+‐Driven Self‐Amplifying Nanoplatform Enables Cascade Photothermal–Gene Therapy via Mitochondrial Disruption

VIEW, EarlyView.
A Zn2+‐activated nanoplatform enables self‐amplifying photothermal–gene therapy by disrupting mitochondria and releasing siRNA, creating a feedback loop that sensitizes tumor cells and enhances ablation in vitro and in vivo. This metal ion‐driven strategy offers a new approach for cascade‐amplified nanotherapeutics. ABSTRACT The therapeutic efficacy of
Zhi Li, Yuhong Chen, Youfei Zhang, Luzhen Huai, Xingzhou Zhu, Xue Mo, Jiahao Wang, Kui Zeng, Jie Wang   +8 more
wiley   +1 more source