Results 191 to 200 of about 426,171 (247)

Single‐Cell Transcriptomic Identification of Drug‐Tolerant Persister Mechanisms in Capecitabine‐Treated Triple‐Negative Breast Cancer

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. This lack of receptors limits targeted therapies and contributes to high rates of recurrence.
Md Naiyem Islam, Md Kaziul Islam Sarkar Suja, Alif Al Takbir, Md. Kaderi Kibria   +3 more
wiley   +1 more source

Chronic Exercise Accelerates Disease Progression in a Rat Model of Desminopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background Desminopathy is a progressive myopathy and the most common intermediate filament disease in humans. Desmin is an essential part of the filamentous network that aligns myofibrils, anchors nuclei and mitochondria and connects the z discs to the sarcolemma.
Henning T. Langer, Natalie Haritonow, Aniket S. Joshi, Alec M. Avey, Alec Bizieff, Hussein Mohammad, Hermann Zbinden‐Foncea, Marc Hellerstein, Katrin Hahn, Werner Stenzel, Keith Baar, Agata A. Mossakowski   +11 more
wiley   +1 more source

Integration of Chemical Probes and Degradomics Reveals That Cathepsin B Functions Primarily as a Dipeptidyl Carboxypeptidase in Macrophages

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
An integrated chemical biology and degradomics approach reveals the proteolytic landscape of cathepsin B in mouse macrophages. Z‐RK‐AOMK perturbs the cysteine cathepsin network and reveals that cathepsin B predominantly exhibits dipeptidyl carboxypeptidase activity in cells.
Kai‐Qi Yek, Francesca L. Apolloni, Bangyan Xu, Nghi H. Nguyen, Alexander R. Ziegler, Nichollas E. Scott, Brad E. Sleebs, Laura E. Edgington‐Mitchell   +7 more
wiley   +1 more source

HSP60-regulated Mitochondrial Proteostasis and Protein Translation Promote Tumor Growth of Ovarian Cancer. [PDF]

Sci Rep, 2019
Guo J, Li X, Zhang W, Chen Y, Zhu S, Chen L, Xu R, Lv Y, Wu D, Guo M, Liu X, Lu W, Deng H.   +12 more
europepmc   +1 more source

The Boron–Neuron Connection: The Potential of Boron‐Containing Molecules for Treating Incurable Amyotrophic Lateral Sclerosis

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
Can a single element help address the multifactorial nature of ALS? Boron‐containing compounds combine responsiveness to reactive oxygen species (ROS), neuroprotective activity, and favorable pharmacological properties, offering a distinctive framework for disease modification in a complex disease like ALS.
Nitesh Sanghai, Billy Vuong, Muhammad Shaharyar K. Afridi, Sasha Leggett, Hemin Roghzai, Geoffrey K. Tranmer   +5 more
wiley   +1 more source

Inflammation and Oxidative Damage in Fatty Acids Oxidation Disorders

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Deficiencies in enzymes and transporters involved in mitochondrial fatty acid beta oxidation results in the accumulation of fatty acids, a condition known as fatty acid oxidation disorders (FAODs). Therefore, the present study aimed to evaluate the oxidative and inflammatory profiles of treated patients with FAODs, comparing those receiving ...
Stefani Altenhofen, Luísa Tedesco, Franciele Fátima Lopes, Marina Acosta, Ângela Sitta, Daniella de Moura Coelho, Bianca Gomes dos Reis, Luiza Wailer, Debora Tonelotto, Ana Kalise Bottcher, Moacir Wajner, Carmen Regla Vargas   +11 more
wiley   +1 more source

Posttranslational Modification Cross‐Talk in Vascular Cells: Molecular Mechanisms and Therapeutic Implications for Atherosclerosis

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Atherosclerosis is driven by coordinated changes in endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs). Post‐translational modifications (PTMs), phosphorylation, acetylation, ubiquitination, SUMOylation, O‐GlcNAcylation, palmitoylation, ISGylation, and ADP‐ribosylation, integrate metabolic, inflammatory, and ...
Weiwei Jiang, Haiping Du
wiley   +1 more source

Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster. [PDF]

PLoS One, 2019
Si H, Ma P, Liang Q, Yin Y, Wang P, Zhang Q, Wang S, Deng H.   +7 more
europepmc   +1 more source

Molecular Adaptations and Sex‐Biased Regulatory Pathways in Multi‐Year Diapause of the Cabbage Beetle Colaphellus bowringi: A Duration‐Resolved Transcriptomic Analysis

Ecology and Evolution, Volume 16, Issue 11, November 2026.
This study presents the first multi‐duration, sex‐stratified transcriptomic analysis of prolonged diapause in Colaphellus bowringi, revealing that extended dormancy is maintained by coordinated metabolic suppression and sustained activation of cytoprotective pathways (e.g., glutathione metabolism, autophagy).
Lili Huang, Yan Ni, Xin Ye, Xiaona Liu, Fangsen Xue, Haimin He   +5 more
wiley   +1 more source

Dietary Polyphenols as Regulators of Protein Deposition and Muscle Health: Mechanisms, Interactions, and Functional Applications

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Dietary polyphenols contribute to the regulation of protein deposition and muscle health through multiple interconnected mechanisms. They promote protein synthesis and myogenic differentiation mainly by modulating the PI3K/AKT/mTOR signaling pathway and myogenic regulatory factors, while suppressing excessive protein degradation through regulation of ...
Chen Liu, Mengyi Ren, Xin Lai, Ke Gu, Liqiang Tan, Aimin Wu, Daiwen Chen   +6 more
wiley   +1 more source