Results 211 to 220 of about 426,171 (247)

More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health. [PDF]

Philos Trans R Soc Lond B Biol Sci
Labbadia J.
europepmc   +1 more source

Diabetic Polyneuropathy Patients Exhibit an Altered Skeletal Muscle Proteome Phenotype

PROTEOMICS – Clinical Applications, Volume 20, Issue 6, November 2026.
ABSTRACT Purpose Diabetic polyneuropathy (DPN) is a debilitating complication of diabetes that affects motor nerves and may impair skeletal muscle health. This study investigated skeletal muscle proteomic alterations associated with DPN compared with type 2 diabetes without DPN (T2D) and healthy controls (CON).
Frederik Forsberg Thybo, Karolina Snopek Khan, Jesper Emil Jakobsgaard, Henning Andersen, Kristian Vissing, Johan Palmfeldt   +5 more
wiley   +1 more source

Conserved IQ motifs, divergent apo‐calmodulin recognition in UBE3B and UBE3C

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Calmodulin (CaM) regulates diverse signaling proteins through recognition of short linear motifs, including isoleucine‐glutamine (IQ) motifs that commonly bind Ca2+‐free CaM (apo‐CaM). The homologous to E6AP carboxyl terminus (HECT) E3 ubiquitin ligases ubiquitin protein ligase E3B (UBE3B) and ubiquitin protein ligase E3C (UBE3C) are closely ...
Emily G. Schaffter, Xiaohuan Lu, Anna E. Tinklenberg, Megan G. Hill, Rafael H. Levin, Javier F. Tabima, Shuanghong Huo, Donald E. Spratt   +7 more
wiley   +1 more source

Regulation of cellular proteostasis via mitochondrial protein import. [PDF]

Philos Trans R Soc Lond B Biol Sci
Nguyen NGT, Li J.
europepmc   +1 more source

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

Aging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park, Eun Roh, Jae Woo Park, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Ji Soo Kim, Mun Gyeom Kim, Myeong Ju Kim, Young In Cho, Wontae Jeong, Gil Myoung Kang, Sang‐Yeob Kim, Se Hee Min, Min‐Seon Kim   +15 more
wiley   +1 more source

The microbiota-proteostasis axis: implications in neurodegenerative diseases. [PDF]

Philos Trans R Soc Lond B Biol Sci
Czyż DM, Brown BM.
europepmc   +1 more source

In Vivo Partial Cell Reprogramming With Yamanaka Factors Reduced Ischemic Brain Damage in Aging Mice

Aging Cell, Volume 25, Issue 11, November 2026.
Short‐term cyclic partial reprogramming with Yamanaka factors protects aged mice from ischemic brain injury, preserving cognitive function, myelin integrity, and neuronal density, supporting partial reprogramming as a promising neuroprotective intervention in aging.
Paula R. Mallavibarrena, Gerardo Martín‐López, Jorge Rodríguez‐Morales, Jesús Ávila, Félix Hernández, María José Pérez‐Álvarez   +5 more
wiley   +1 more source

Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, or MSC rejuvenation may preserve regenerative capacity during aging. ABSTRACT Aging is accompanied by a progressive decline in tissue regenerative capacity,
Shaianne N. Stein, Lorena R. Braid
wiley   +1 more source