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Roles of mitochondrial localization in neuronal proteostasis
Roles of mitochondrial localization in neuronal proteostasisopenaire +1 more source
Cytosolic Proteostasis Networks of the Mitochondrial Stress Response
Trends in Biochemical Sciences, 2017 Mitochondrial stress requires timely intervention to prevent mitochondria' and cellular dysfunction. Re-establishing the correct protein homeostasis is crucial for coping with mitochondria' stress and maintaining cellular homeostasis.
Johan Auwerx +2 more
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Mechanisms Linking Mitochondrial Dysfunction and Proteostasis Failure
Trends in Cell Biology, 2020 Maintaining cellular protein homeostasis (proteostasis) is an essential task for all eukaryotes. Proteostasis failure worsens with aging and is considered a cause of and a therapeutic target for age-related diseases including neurodegenerative disorders.
Bingwei Lu, Su Guo
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A Mitochondrial Stress-Specific Form of HSF1 Protects Against Age-Related Proteostasis Collapse [PDF]
Developmental Cell, 2020 The loss of protein homeostasis (proteostasis) is a primary driver of age-related tissue dysfunction. Recent studies have revealed that the failure of proteostasis with age is triggered by developmental and reproductive cues that repress the activity of ...
Johnathan Labbadia
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Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis [PDF]
Cell, 2016 During neurodegenerative disease, the toxic accumulation of aggregates and misfolded proteins is often accompanied with widespread changes in peripheral metabolism, even in cells in which the aggregating protein is not present. The mechanism by which the central nervous system elicits a distal reaction to proteotoxic stress remains unknown.
Jenni Durieux, Andrew Dillin, Ye Tian
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A Role for Mitochondrial DNA in Cellular Proteostasis
Nature Reviews Genetics, 2021This molecular phenotyping study shows that common variants in mitochondrial DNA associated with diseases of ageing influence cellular protein homeostasis, and that this link is mediated by circulating levels of N-formylmethionine, the initiating amino acid in mitochondrial protein synthesis.
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MISTERMINATE Mechanistically Links Mitochondrial Dysfunction With Proteostasis Failure [PDF]
Molecular Cell, 2019 SUMMARY Mitochondrial dysfunction and proteostasis failure frequently coexist as hallmarks of neurodegenerative disease. How these pathologies are related is not well understood. Here we describe a phenomenon termed MISTERMINATE ( mi tochondrial s
Jason Dong, Onn Brandman, Bingwei Lu
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Mitochondrial metabolism regulates cellular proteostasis
03.03 - Mechanisms of lung injury and repair, 2020Protein homeostasis involving protein synthesis and degradation by the proteasome system is intricately balanced in the cell and fine-tuned according to cellular needs and upon stress. Metabolic regulation of protein synthesis and proteasome activity by respiratory chain dysfunction has not been investigated so far.
T Meul +14 more
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Machinery in motion: New insights into mitochondrial proteostasis
The FASEB Journal, 2022ATP‐dependent AAA+ proteases are critical regulators of mitochondrial functions, playing crucial roles in the mitochondrial quality control response system. The past years have provided much structural insight into the molecular mechanisms associated with degradation of substrates by these proteolytic machines. Recent cryo‐electron microscopy (cryo‐EM)
Gabriel Lander, Jeff Mindrebo
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Mitochondrial Proteostasis and Cellular Health: Insights From Chaperones and Autophagy
Journal of PhysiologyAbstractMitochondria are a cell's powerhouse and also have a vital part in cellular processes. The emerging role of mitochondria in several crucial processes highlights their cellular and physiological importance. Mitochondrial homeostasis mechanisms, including proteostasis pathways, are vital for mitochondrial health. Failure of these processes has an
Vivek Sharma, Amit Mishra, Anil K Suresh
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