Results 221 to 230 of about 426,171 (247)

Tree Shrew as an Emerging Model for Aging Research: Characterization of Senescence and Therapeutic Interventions

Aging Cell, Volume 25, Issue 11, November 2026.
Compared with mouse cells, tree shrew fibroblasts more faithfully recapitulate the hallmarks of human cellular senescence. In vivo, aged tree shrews exhibit transcriptomic signatures of aging across multiple organs that closely mirror those observed in humans.
Qiuni Luo, Wenxian Xiao, Xin Dong, Ayesha Nisar, Yuhua Ma, Xiang Lai, Raoxian Bai, Meiting Zi, Qi Geng, Qingyu Zhang, Cheng Zhang, Qiong Wang, Naheemat Modupeola Gold, Zhen Zhou, Li Hu, Ao Zhang, Qinghua Zeng, Jing Liu, Sawar Khan, Longbao Lv, Yonghan He   +20 more
wiley   +1 more source

Disruption of RNA metabolism and its impact on protein homeostasis. [PDF]

Philos Trans R Soc Lond B Biol Sci
Garcia SMDA.
europepmc   +1 more source

FGF13 Alleviates the Aging Process in Mice by Regulating Astrocyte Function in the Medial Prefrontal Cortex via Phafin2 Signaling Pathway

Aging Cell, Volume 25, Issue 11, November 2026.
FGF13 is significantly downregulated in the aging brain, particularly in cortical astrocytes within the medial prefrontal cortex. Genetic knockdown of FGF13 in astrocytes accelerates aging phenotypes and impairs neurological function in mice, while its overexpression effectively delays cognitive decline.
Rui Zheng, Zheng Tu, Yang Fang, Caixiang Zhuang, Yuchao Zhang, Yibo Ying, Zhiyi Feng, Ziyang Jin, Yanyan Zheng, Zhouguang Wang   +9 more
wiley   +1 more source

SIRT1-Redox Crosstalk in Aging: Adaptive Capacity and Cellular State Transitions. [PDF]

Biology (Basel)
Yan M, Hua L, He Y, Li Y, Yang Q, Chen Y.   +5 more
europepmc   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

Beyond cell replacement: restoring organelle homeostasis as the next frontier of regenerative medicine. [PDF]

Front Bioeng Biotechnol
Ferreira-Antunes F, Lima MF, Moreira A, Silva FJ, Sampaio-Marques B, Salgado AJ.   +5 more
europepmc   +1 more source

Disulphide maintenance systems and proteostasis. [PDF]

Philos Trans R Soc Lond B Biol Sci
West JD.
europepmc   +1 more source

Targeting of Protein Persulfidation in Aging and Age-Related Disorders. [PDF]

Pharmaceutics
Hugo M, Garcia-Pardo J.
europepmc   +1 more source

The (European) protein homeostasis network. [PDF]

FEBS J
Chevet E.
europepmc   +1 more source

Cellular and systemic modifiers of alpha-synuclein proteostasis. [PDF]

Philos Trans R Soc Lond B Biol Sci
Couzijn S, Ainslie AP, Herron-Bedoya A, Nollen EAA.   +3 more
europepmc   +1 more source