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Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response. [PDF]
Cancer Cell IntLin N +7 more
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The mitochondrial unfolded protein response: Signaling from the powerhouse [PDF]
Journal of Biological Chemistry, 2017 Mitochondria are multifaceted and indispensable organelles required for cell performance. Accordingly, dysfunction to mitochondria can result in cellular decline and possibly the onset of disease.
Mark W Pellegrino, Cole M Haynes
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Mitochondrial unfolded protein response in ischemia-reperfusion injury
Brain Research, 2022Mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that activates the transcriptional program of mitochondrial chaperone proteins and proteases to keep protein homeostasis in mitochondria. Ischemia-reperfusion injury results in multiple severe clinical issues linked to high morbidity and mortality in various disorders ...
Ming-Xi, Zhu +4 more
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Targeting the mitochondrial unfolded protein response in cancer: opportunities and challenges
Trends in Cancer, 2021Increasing evidence indicates that a mitochondria-specific stress response referred to as the 'mitochondrial unfolded protein response' (UPRmt) is activated to maintain mitochondrial integrity and support tumor growth. In this forum article, we discuss the recent advances and current challenges in therapeutically targeting UPRmt in cancer.
Rahul Kumar, Dhyan Chandra
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A New Vision of Mitochondrial Unfolded Protein Response to the Sirtuin Family [PDF]
Current Neuropharmacology, 2020 Mitochondrial damage is involved in many pathophysiological processes, such as tumor development, metabolism, and neurodegenerative diseases. The mitochondrial unfolded protein response (mtUPR) is the first stress-protective response initiated by mitochondrial damage, and it repairs or clears misfolded proteins to alleviate this damage.
Lina Chen, Yihong Ma, Shaochuan Zhang
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Mitochondrial Unfolded Protein Response (mtUPR) and Diseases
Current Medicinal ChemistryMitochondria are the energy factories of cells, and their functions are closely related to cell homeostasis. The mitochondrial unfolded protein response (mtUPR) is a newly discovered mechanism for regulating mitochondrial homeostasis. When unfolded/ misfolded proteins accumulate in mitochondria, the mitochondria release signals that regulate the ...
Ming, Yang +7 more
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Assessing Mitochondrial Unfolded Protein Response in Mammalian Cells
2017Mitochondria serve a key role in the supply of energy to cells in the form of ATP, the supply of essential cellular components such as phospholipids and heme, in apoptosis and as a mediator of cellular signaling pathways. Mitochondria have their own DNA, consisting of a small number of genes, but the majority of the total protein complement is encoded ...
Fiona, Durand, Nicholas, Hoogenraad
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Uncovering a Mitochondrial Unfolded Protein Response
Science's STKE, 2007Proteins are synthesized and folded and assembled in the cytosol, endoplasmic reticulum (ER), and mitochondria. For the cytosol and ER, pathways associated with excess unfolded or misfolded proteins have been characterized and are called the heat shock response and the ER unfolded protein response (UPR er ). Haynes
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Mitochondrial unfolded protein response: An emerging pathway in human diseases
Free Radical Biology and Medicine, 2021Mitochondrial unfolded protein response (UPRmt) is a mitochondria stress response, which the transcriptional activation programs of mitochondrial chaperone proteins and proteases are initiated to maintain proteostasis in mitochondria. Additionally, the activation of UPRmt delays aging and extends lifespan by maintaining mitochondrial proteostasis ...
Li Zhu, Qionglin Zhou, Lu He, Linxi Chen
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Mitochondrial Unfolded Protein Response and Its Roles in Stem Cells
Stem Cells and Development, 2020The mitochondrial unfolded protein response (UPR mt ) is a mitochondrial protein quality control mechanism that is involved in many pathophysiological activities and maintains cellular homeostasis. The UPR mt signaling pathway in both
Lin-Lin Wang, Gerong Shen
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