Results 251 to 260 of about 8,821,559 (269)

The Mitochondrial Unfolded Protein Response: Role in Cellular Homeostasis and Disease

Current Molecular Medicine, 2018
Mitochondria are the sole semiautonomous organelles of the human cell and play a very important role in not only energy production but also in apoptosis, metabolism and cell signaling. They are also known to be major producers of ROS and RNS free radicals during ATP production. These free radicals in excessive amount may damage the mitochondrial DNA as
I, De, N, Dogra, S, Singh
openaire   +2 more sources

Methods to analyze the mitochondrial unfolded protein response (UPRmt)

The mitochondrial unfolded protein response (UPRmt) is a mitochondria-to-nuclear signaling pathway that mediates the transcription of genes required to maintain mitochondrial function during development as well as during aging. In this chapter, we describe the approaches and techniques that we and others have used to elucidate the mechanism(s) by which
Avijit, Mallick, Cole M, Haynes
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Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum

Neurochemistry International, 2011
Stress in mitochondria or the endoplasmic reticulum (ER) independently causes cell death. Recently, it was reported that ER stress causes mitochondrial dysfunction via p53-upregulated modulator of apoptosis (PUMA). However, little is known regarding the mitochondria molecules that mediate ER dysfunction.
Kana, Takemoto, Shingo, Miyata, Hironori, Takamura, Taiichi, Katayama, Masaya, Tohyama   +4 more
openaire   +2 more sources

Regulation of the mammalian mitochondrial unfolded protein response [PDF]

, 2015
The molecular mechanisms of the mammalian mitochondrial unfolded protein response (UPRmt) are largely unknown. In this study, in vitro as well as in vivo models were used to assess the role of the mitochondrial chaperones and proteases as well as potential signalling factors in the context of the mammalian UPRmt.
openaire  

Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury

Redox Biology, 2021
Hao Zhou, Sam Toan, Xing Chang
exaly  

Mitochondrial Unfolded Protein Response and Integrated Stress Response as Promising Therapeutic Targets for Mitochondrial Diseases

Cells, 2023
Ya-jing Liu, Chunmei Liang, Weiwei Zou
exaly  

FUNDC1 activates the mitochondrial unfolded protein response to preserve mitochondrial quality control in cardiac ischemia/reperfusion injury

Cellular Signalling, 2022
Hao Zhou, Wei Song, Yinong Jiang
exaly  

Mitochondrial Unfolded Protein Response (mtUPR) and Diseases

Current Medicinal Chemistry, 2023
Liyu He
exaly  

Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response

Environmental Pollution, 2022
Jin-Long Li, Milton Talukder, Jia-Gen Cui   +2 more
exaly  

The mitochondrial unfolded protein response and its diverse roles in cellular stress

International Journal of Biochemistry and Cell Biology, 2021
Ioannis Smyrnias
exaly