Results 21 to 30 of about 16,238 (247)
IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy [PDF]
Cardiovascular ResearchAbstract Aims The mitochondrial dynamics protein Mitofusin 2 (MFN2) coordinates critical cellular processes including mitochondrial bioenergetics, quality control, and cell viability. The NF-κB kinase IKKβ suppresses mitochondrial injury in doxorubicin cardiomyopathy, but the underlying mechanism is ...
Matthew Guberman +6 more
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Retraction: Matrine protects cardiomyocytes against hyperglycemic stress by promoting mitofusin 2-induced mitochondrial fusion. [PDF]
Front Physiol, 2022 Frontiers Editorial Office.
europepmc +3 more sources
Life Science Alliance, 2023 Our analysis of a CMT2A-associated mitofusin variant reveals that aberrant mitochondrial tethering results in perinuclear clusters and that conformational dynamics in Hinge 2 are required to progress from membrane tethering to membrane fusion.
Stephanie R Sloat, Suzanne Hoppins
doaj +1 more source
Functional implications of mitofusin 2-mediated mitochondrial-SR tethering [PDF]
Journal of Molecular and Cellular Cardiology, 2014 Cardiomyocyte mitochondria have an intimate physical and functional relationship with sarcoplasmic reticulum (SR). Under normal conditions mitochondrial ATP is essential to power SR calcium cycling that drives phasic contraction/relaxation, and changes in SR calcium release are sensed by mitochondria and used to modulate oxidative phosphorylation ...
Gerald W. Dorn +2 more
openalex +4 more sources
Mitofusin-2 is required for mouse oocyte meiotic maturation [PDF]
Scientific Reports, 2016 AbstractMitofusin-2 (Mfn2) is essential for embryonic development, anti-apoptotic events, protection against free radical-induced lesions and mitochondrial fusion in many cells. However, little is known about its mechanism and function during oocyte maturation.
Jinghua Zhang +10 more
openalex +3 more sources
Adropin Alleviates Myocardial Fibrosis in Diabetic Cardiomyopathy Rats: A Preliminary Study
Frontiers in Cardiovascular Medicine, 2021 Aim: Adropin (ADR) is a novel regulatory polypeptide and has important effects on energy metabolism in the heart. However, it is still unclear whether ADR can relieve ventricular remodeling in DCM. Therefore, this study was conducted to assess the effect
Mao Liu +5 more
doaj +1 more source
Unveiling a Rare Phenotypic Presentation of Mitofusin 2 Mutation as Cerebellar Ataxia [PDF]
Annals of Indian Academy of NeurologyPriya Robert +3 more
doaj +2 more sources
Mitofusin-2 enhances cervical cancer progression through Wnt/β-catenin signaling. [PDF]
BMB RepAhn SY.
europepmc +3 more sources
Mitofusin 2: from functions to disease [PDF]
Cell Death & Disease, 2018 AbstractMitochondria are highly dynamic organelles whose functions are essential for cell viability. Within the cell, the mitochondrial network is continuously remodeled through the balance between fusion and fission events. Moreover, it dynamically contacts other organelles, particularly the endoplasmic reticulum, with which it enterprises an ...
Filadi, Riccardo +2 more
openaire +4 more sources
Frontiers in Physiology, 2021 Cardiac fibrosis is evident even in the situation without a significant cardiomyocyte loss in diabetic cardiomyopathy and a high glucose (HG) level independently activates the cardiac fibroblasts (CFs) and promotes cell proliferation.
Ling-Yu Zhang +13 more
doaj +1 more source