Results 181 to 190 of about 12,377 (209)
Some of the next articles are maybe not open access.
Role of mitofusin 2 in cardiovascular oxidative injury
Journal of Molecular Medicine, 2010Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential ...
Ming, Zheng, Rui-Ping, Xiao
openaire +2 more sources
Relationship between mitofusin 2 and cancer
2019Mitochondria are dynamic organelles whose actions are fundamental for cell viability. Within the cell, the mitochondrial system is incessantly modified via the balance between fusion and fission processes. Among other proteins, mitofusin 2 is a central protagonist in all these mitochondrial events (fusion, trafficking, contacts with other organelles ...
A. Allegra +3 more
openaire +3 more sources
Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance The privileged interrelationship between mitochondria and the endoplasmic reticulum (ER) plays a key role in a variety of physiological functions, from lipid metabolism to Ca 2+ signalling, and its modulation influences apoptotic susceptibility, mitophagy, and ...
Riccardo Filadi +2 more
exaly +4 more sources
Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling
Science Signaling, 2009A protein that mediates mitochondrial fusion also suppresses innate immune responses to viral infection.
Kai, Yasukawa +7 more
openaire +2 more sources
Doxorubicin-induced cardiomyocyte apoptosis: Role of mitofusin 2
The International Journal of Biochemistry & Cell Biology, 2017Doxorubicin (DOX) is an anti-tumor agent that is widely used in clinical setting for cancer treatment. The application of the DOX, however, is limited by its cardiac toxicity which can induce heart failure through an undefined mechanism. Mitofusin 2 (Mfn2) is a mitochondrial GTPase fusion protein that is located on the outer membrane of mitochondria ...
Han, Tang +5 more
openaire +2 more sources
Altered expression of mitofusin 2 in penile tissues of diabetic rats
Andrologia, 2013Diabetic erectile dysfunction (ED) is a common complication in diabetes mellitus, and the efficacy of first-line therapies is not satisfactory. Recent studies revealed that corporal apoptosis was responsible for the nonresponsiveness of severe ED to phosphodiesterase type 5 inhibitors. Mitofusin 2 (Mfn2) is a versatile protein, regulating mitochondrial
J, Yang +7 more
openaire +2 more sources
IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy
Cardiovascular ResearchAbstract Aims The mitochondrial dynamics protein Mitofusin 2 (MFN2) coordinates critical cellular processes including mitochondrial bioenergetics, quality control, and cell viability. The NF-κB kinase IKKβ suppresses mitochondrial injury in doxorubicin cardiomyopathy, but the underlying mechanism is ...
Matthew Guberman +6 more
openaire +2 more sources
Research Progress of Mitofusin-2*
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2010Guang-Ju ZHAO +2 more
openaire +1 more source
E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
Molecular Cell, 2023Vincent Anton +2 more
exaly