Results 171 to 180 of about 12,377 (209)

Endosomal RFFL ubiquitin ligase regulates mitochondrial morphology by targeting mitofusin 2.

J Cell Sci
Narendradev ND, Ravindran R, Jain P, Chaudhary S, Velikkakath AKG, Sudharman A, Janardhanan A, Nag TC, Yadav SC, Srinivasula SM.   +9 more
europepmc   +1 more source

Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2. [PDF]

J Physiol Sci
Olaniyi KS, Areloegbe SE.
europepmc   +1 more source

Prenatal hormone stress triggers embryonic cardiac hypertrophy outcome by ubiquitin-dependent degradation of mitochondrial mitofusin 2. [PDF]

iScience
Yan CY, Ye Y, Mu HL, Wu T, Huang WS, Wu YP, Sun WY, Liang L, Duan WJ, Ouyang SH, Huang RT, Wang R, Sun XX, Kurihara H, Li YF, He RR.   +15 more
europepmc   +1 more source

Mitofusin 2 tethers endoplasmic reticulum to mitochondria [PDF]

Nature, 2008
Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown.
Olga Martins DE BRITO, Luca Scorrano, Scorrano Luca   +2 more
exaly   +6 more sources

Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2 [PDF]

Pharmacological Research, 2018
The endoplasmic reticulum (ER) and the mitochondrial network are two highly interconnected cellular structures. By proteinaceous tethers, specialized membrane domains of the ER are tightly associated with the outer membrane of mitochondria, allowing the ...
Riccardo Filadi, Elisa Greotti, Paola Pizzo   +2 more
exaly   +5 more sources

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Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis

Kidney International, 2022
Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease.
Divya Bhatia, Allyson Capili, Kiichi Nakahira, Thangamani Muthukumar, Lisa K. Torres, Augustine M.K. Choi, Mary E. Choi   +6 more
openaire   +2 more sources

Mitofusin-2 in cancer: Friend or foe?

Archives of Biochemistry and Biophysics, 2022
Cancer is a category of disorders characterized by excessive cell proliferation with the ability to infiltrate or disseminate to other organs of the body. Mitochondrial dysfunction, as one of the most prominent hallmarks of cancer cells, has been related to the onset and development of various cancers.
Pushpamala, Ramaiah, Indrajit, Patra, Anum, Abbas, Ali Abdulhussain, Fadhil, Mohammad, Abohassan, Zahraa Haleem, Al-Qaim, Noora Mohammed, Hameed, Moaed Emran, Al-Gazally, Saif Sabbar, Kemil Almotlaq, Yasser Fakri, Mustafa, Yavar, Shiravand   +10 more
openaire   +2 more sources

Targeted Deletion of Mitofusin 1 and Mitofusin 2 Causes Female Infertility and Loss of Follicular Reserve

Reproductive Sciences, 2022
Mitochondria are dynamic organelles that regulate their size, shape, and morphology through mechanisms called fusion and fission, to continually adapt themselves to their bioenergetic environment. These mechanisms play a critical role to maintain the mitochondrial function under metabolic and environmental stress.
Mauro Cozzolino, Yagmur Ergun, Emre Seli
openaire   +2 more sources

Mitofusin-2 is a novel direct target of p53

Biochemical and Biophysical Research Communications, 2010
The tumor suppressor p53 modulates transcription of a number of target genes involved in cell cycle arrest, apoptosis, DNA repair, and other important cellular responses. Mitofusin-2 (Mfn2) is a novel suppressor of cell proliferation that may also exert apoptotic effects via the mitochondrial apoptotic pathway.
Weilin, Wang, Xiaofei, Cheng, Jianju, Lu, Jianfeng, Wei, Guanghou, Fu, Feng, Zhu, Changku, Jia, Lin, Zhou, Haiyang, Xie, Shusen, Zheng   +9 more
openaire   +2 more sources