A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly [PDF]
Nature CommunicationsThe mitochondrion is a highly dynamic organelle, constantly undergoing fusion and fission, which are critical processes for the health of cells. Fusion of the outer mitochondrial membrane (OMM) is mediated by the mitofusins belonging to the dynamin ...
Shu-Jing Huang +16 more
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Mitochondrial fusion is required for spermatogonial differentiation and meiosis [PDF]
eLife, 2019 Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Grigor Varuzhanyan +6 more
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Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease [PDF]
Frontiers in Cell and Developmental BiologyMitochondrial dynamics, involving fission and fusion, are vital for maintaining mitochondrial quality, shape, and function in heart cells. This review explores how key regulators—Dynamin-related protein 1 (Drp1), mitofusins 1 and 2 (Mfn1/2), and Optic ...
Tengxu Zhang +5 more
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Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution [PDF]
Cell Reports, 2018 Summary: Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors.
Tatiana Trevisan +5 more
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High intensity interval training alters gene expression linked to mitochondrial biogenesis and dynamics in high fat diet fed rats [PDF]
Scientific ReportsA High-Fat Diet (HFD) leads to disruption of mitochondrial biogenesis and dynamics. Exercise training, especially High-Intensity Interval Training (HIIT) increases mitochondrial biogenesis and dynamics.
Mohammad Jahangiri +2 more
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Leflunomide Treatment Does Not Protect Neural Cells following Oxygen-Glucose Deprivation (OGD) In Vitro [PDF]
CellsNeonatal hypoxia-ischemia (HI) affects 2–3 per 1000 live births in developed countries and up to 26 per 1000 live births in developing countries. It is estimated that of the 750,000 infants experiencing a hypoxic-ischemic event during birth per year ...
Claire J. M. Curel +2 more
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iScience, 2023 Summary: Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power membrane-remodeling events via self-interaction and GTP hydrolysis.
Ira Buntenbroich +8 more
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Piperine Derivatives Enhance Fusion and Axonal Transport of Mitochondria by Activating Mitofusins
Chemistry, 2022 Piperine (1-piperoylpiperidine) is the major pungent component of black pepper (Piper nigrum) and exhibits a spectrum of pharmacological activities. The molecular bases for many of piperine’s biological effects are incompletely defined. We noted that the
Lihong Zhang +4 more
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A human mitofusin 2 mutation can cause mitophagic cardiomyopathy
eLife, 2023 Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15–20× over-represented in
Antonietta Franco +12 more
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Modulating mitofusins to control mitochondrial function and signaling
Nature Communications, 2022 Mitofusins regulate mitochondrial fusion. Here the authors identify small molecules that activate or inhibit mitofusins’ activity and modulate mitochondrial fusion and functionality.
Emmanouil Zacharioudakis +20 more
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