Results 101 to 110 of about 5,278 (225)

Regulating a uniter: control of mitofusin 2 expression [PDF]

Cardiovascular Research, 2012
This editorial refers to ‘The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells’ by E. Sorianello et al. , pp. 38–47, this issue. Sorianello et al. 1 provide important new information on the regulation on mitofusin (Mfn)2 expression.
Anne A, Knowlton, Le, Chen
openaire   +2 more sources

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction [PDF]

, 2016
Mitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as the sarcoplasmic reticulum (SR).
Burke, N, Dongworth, RK, Dorn Ii, GW, Dyson, A, Hall, AR, Hausenloy, DJ, Kalkhoran, SB, Vicencio, JM, Yellon, DM   +8 more
core   +2 more sources

Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency [PDF]

Cell Death & Differentiation, 2015
Cell reprogramming technology has allowed the in vitro control of cell fate transition, thus allowing for the generation of highly desired cell types to recapitulate in vivo developmental processes and architectures. However, the precise molecular mechanisms underlying the reprogramming process remain to be defined. Here, we show that depleting p53 and
M J, Son, Y, Kwon, M-Y, Son, B, Seol, H-S, Choi, S-W, Ryu, C, Choi, Y S, Cho   +7 more
openaire   +2 more sources

Optimal timing to assess exercise‐induced oxidative stress: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract There is a lack of consensus on optimal timing to assess redox biomarkers post‐exercise, limiting methodological standardisation and linking oxidative stress to physiology. We determined optimal post‐exercise oxidative stress assessment times using three redox biomarkers: glutathione, F2‐isoprostanes and protein carbonyls.
Chrysovalantis Stachteas, Nikolaos Georgogiannis, George G. Nastos, Panagiotis N. Chatzinikolaou, Petros C. Dinas, Anastasios A. Theodorou, Vassilis Paschalis, Ioannis S. Vrabas, Antonios Kyparos, Athanasios Z. Jamurtas, Ioannis G. Fatouros, Michalis G. Nikolaidis, Nikos V. Margaritelis   +12 more
wiley   +1 more source

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion [PDF]

, 2017
Mitochondria are double-membraned organelles with variable shapes influenced by metabolic conditions, developmental stage, and environmental stimuli. Their dynamic morphology is a result of regulated and balanced fusion and fission processes.
A Franco, A Santel, A Vagin, AB Knott, AJ McCoy, B Prakash, Bing Yu, C Fröhlich, David C. Chan, DC Chan, Dong-Dong Gu, E Krissinel, GJ Praefcke, GM Sheldrick, GN Murshudov, H Chen, HH Low, HH Low, HT McMahon, JC Stachowiak, JD Thompson, Jian-Xiong Feng, Jin-Yu Yang, JM Shaw, JP Richard, JR Friedman, JS Chappie, K Faelber, K Nakada, LA Kelley, LJ Byrnes, LJ Byrnes, M Karbowski, M Ranieri, M Rojo, MG Ford, ML Rennie, MM Kozlov, MP Yaffe, N Ishihara, O Daumke, P Emsley, P Mishra, PD Adams, RA Laskowski, RJ Youle, S Gao, S Gao, S Hoppins, Shuang Liao, Shuxia Meng, Song Gao, T Brandt, T Koshiba, T Pape, TY Liu, VB Chen, W Kabsch, X Bian, Yang Chen, Yu-Jie Li, Yu-Lu Cao   +61 more
core   +1 more source

Loss of Mitofusin 2 Promotes Endoplasmic Reticulum Stress [PDF]

Journal of Biological Chemistry, 2012
The outer mitochondrial membrane GTPase mitofusin 2 (Mfn2) is known to regulate endoplasmic reticulum (ER) shape in addition to its mitochondrial fusion effects. However, its role in ER stress is unknown. We report here that induction of ER stress with either thapsigargin or tunicamycin in mouse embryonic fibroblasts leads to up-regulation of Mfn2 mRNA
Gladys A, Ngoh, Kyriakos N, Papanicolaou, Kenneth, Walsh   +2 more
openaire   +2 more sources

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases

Antioxidants, 2017
Neurodegenerative diseases are incurable and devastating neurological disorders characterized by the progressive loss of the structure and function of neurons in the central nervous system or peripheral nervous system.
Ju Gao, Luwen Wang, Jingyi Liu, Fei Xie, Bo Su, Xinglong Wang   +5 more
doaj   +1 more source

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

Experimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova, Evgenii Lysenko, Fabio Sarto, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +6 more
wiley   +1 more source