Results 91 to 100 of about 5,369 (241)

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

Downregulation of Mitofusin 2 in Placenta Is Related to Preeclampsia [PDF]

BioMed Research International, 2016
Background. Mitofusin 2 (Mfn2) is a novel mitochondrial protein that is implicated in cellular proliferation and metabolism; however, the role of Mfn2 in preeclampsia (PE) remains unknown. This study aimed to explore the relationship between Mfn2 and PE.Method. Preeclamptic and normal pregnancies were enrolled in a comparative study.
Yu, Jun, Guo, Xijiao, Chen, Ruibao, Feng, Ling   +3 more
openaire   +2 more sources

Functional wiring of proteostatic and mitostatic modules ensures transient organismal survival during imbalanced mitochondrial dynamics

Redox Biology, 2019
Being an assembly of protein machines, cells depend on adequate supply of energetic molecules for retaining their homeodynamics. Consequently, mitochondria functionality is ensured by quality control systems and mitochondrial dynamics (fusion/fission ...
Sentiljana Gumeni, Zoi Evangelakou, Eleni N. Tsakiri, Luca Scorrano, Ioannis P. Trougakos   +4 more
doaj   +1 more source

Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation

Life Science Alliance, 2020
Mitochondrial fusion requires a conformational change in α4 of the GTPase domain, followed by AAA-ATPase regulation, thus revealing striking mechanistic similarities between small and large GTPases. Mitochondria are essential organelles whose function is
Ramona Schuster, Vincent Anton, Tânia Simões, Selver Altin, Fabian den Brave, Thomas Hermanns, Manuela Hospenthal, David Komander, Gunnar Dittmar, R Jürgen Dohmen, Mafalda Escobar-Henriques   +10 more
doaj   +1 more source

MFN2 point mutations occur in 3.4% of Charcot-Marie-Tooth families. An investigation of 232 Norwegian CMT families [PDF]

, 2010
Background Point mutations in the mitofusin 2 (MFN2) gene has been identified exclusively in Charcot-Marie-Tooth type 2 (CMT2), and in a single family with intermediate CMT. MFN2 point mutations are probably the most common cause of CMT2.
Geir J Braathen, Jette C Sand, Ana Lobato, Helle Høyer, Michael B Russell, H Skre, PJ Dyck, AE Harding, G Nicholson, AE Harding, K Kijima, VH Lawson, K Verhoeven, A Santel, M Rojo, H Skre, H Skre, H Skre, PJ Dyck, S Rozen, JT den Dunnen, NK Aarskog, S Züchner, C Neusch, K Engelfried, I Banchs, D Zhu, KW Chung, S Züchner   +28 more
core   +1 more source

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors. [PDF]

PLoS ONE, 2017
Mitochondria are essential, dynamic organelles that respond to a number of stressors with changes in morphology that are linked to several mitochondrial functions, though the mechanisms involved are poorly understood.
Laura E Newman, Cara R Schiavon, Chengjing Zhou, Richard A Kahn   +3 more
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

The role of the mitofusins in adipose tissue

, 2022
Monogenic mitochondrial disease is known to cause tissue-selective manifestations, typically affecting the nervous system, liver, and muscle. However, until recently, there was relatively little human genetic evidence for a role of mitochondria in disorders of energy balance (i.e. weight) or insulin action. Several groups have identified that biallelic
openaire   +1 more source

LncRNA ANRIL mediates endothelial dysfunction through BDNF downregulation in chronic kidney disease

Cell Death and Disease, 2022
Endothelial dysfunction is common in patients with chronic kidney disease (CKD), but the mechanism is unknown. In this study, we found that the circulating ANRIL level was increased and correlated with vascular endothelial dysfunction in patients with ...
Hong Su, Bing Liu, Huimin Chen, Tingwei Zhang, Tongtong Huang, Yue Liu, Cheng Wang, Qiqi Ma, Qianhui Wang, Zhimei Lv, Rong Wang   +10 more
doaj   +1 more source