Results 101 to 110 of about 5,369 (241)

Mitochondrial dynamics and inheritance during cell division, development and disease [PDF]

, 2014
During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with that of other organelles, particularly in the use of interactions with ...
Chan, David C., Mishra, Prashant
core   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Mitophagy, Mitochondrial Homeostasis, and Cell Fate

Frontiers in Cell and Developmental Biology, 2020
Mitochondria are highly plastic and dynamic organelles that have graded responses to the changing cellular, environmental, and developmental cues. Mitochondria undergo constant mitochondrial fission and fusion, mitochondrial biogenesis, and mitophagy ...
Kaili Ma, Guo Chen, Wenhui Li, Oliver Kepp, Oliver Kepp, Yushan Zhu, Quan Chen   +6 more
doaj   +1 more source

Mitochondrial dynamics and quality control in Huntington's disease [PDF]

, 2015
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by polyglutamine expansion mutations in the huntingtin protein. Despite its ubiquitous distribution, expression of mutant huntingtin (mHtt) is particularly detrimental to medium ...
de Proença, J, Duchen, MR, Guedes-Dias, P, Oliveira, JM, Pinho, BR, Soares, TR   +5 more
core   +1 more source

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin [PDF]

, 2010
Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular processes including protein degradation, mitochondrial homeostasis, and autophagy;
A. J. Whitworth, Bueler, Chu, Clark, De Vos, E. Ziviani, Exner, Fallon, Gasser, Geisler, Kim, Koshiba, Liesa, Lim, Moore, Morais, Mortiboys, Narendra, Park, Park, Popp, R. N. Tao, Sandebring, Shimura, Soubannier, Steinbrink, Tatsuta, Twig, Whitworth   +28 more
core   +2 more sources

TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function. [PDF]

, 2019
Macrophages are a reservoir for latent human immunodeficiency type 1 (HIV) infection and a barrier to HIV eradication. In contrast to CD4+ T cells, macrophages are resistant to the cytopathic effects of acute HIV infection.
Abbas, Abbas, Abbas, Altay, Bergemann, Bleharski, Boliar, Bouchon, Bouchon, Bullen, Campbell, Campbell, Campbell, Campbell, Campbell, Castellano, Chen, Clayton, Cory, de Mareuil, Denner, Duncan, El Mezayen, Frankfurt, Ganor, Gartner, Guillemard, Hara, Haselmayer, Honeycutt, Honeycutt, Hyun, Igarashi, Japour, Jobe, Jobe, Kozik, Laird, Leboucher, Lei, López-Huertas, Mohamadzadeh, Netea, Pelham, Puthalakath, Pyakurel, Radsak, Ratner, Ruiz-Pacheco, Shan, Singh, Spivak, Suthar, Swingler, Verma, Walker-Sperling, Wauquier, Wei, Wolf, Wong-Baeza, Yang, Yuan, Yuan, Zeng   +63 more
core   +2 more sources

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria tethering [PDF]

Proceedings of the National Academy of Sciences, 2017
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Greotti E, Turacchio G, Luini A, Pozzan T, Pizzo P, Filadi R   +5 more
openaire   +4 more sources

Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases

Antioxidants, 2017
Neurodegenerative diseases are incurable and devastating neurological disorders characterized by the progressive loss of the structure and function of neurons in the central nervous system or peripheral nervous system.
Ju Gao, Luwen Wang, Jingyi Liu, Fei Xie, Bo Su, Xinglong Wang   +5 more
doaj   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source