Results 101 to 110 of about 3,343 (171)

HT-29 cells’ mitochondrial networks and fusion proteins upon TNF treatment.

, 2016
(A), Representative images of HT-29 cells expressing green fluorescent protein (GFP) targeted to mitochondria in control and treated cells. (B and C) Quantitative analysis of mitochondrial structure using morphological parameters (Aspect Ratio and Form ...
Mireille Laforge (349277), Sunghoon Lee (19395), Pierre Rustin (53906), Jean-François Benoist (337673), Jérome Estaquier (2602606), Gabriel Péranzi (2602615), Jean-Jacques Lacapère (2602609), Vassilios Papadopoulos (6785), Leeyah Issop (2602612), Mariano A. Ostuni (2602618)   +9 more
core   +1 more source

AIBP: A New Safeguard against Glaucomatous Neuroinflammation

Cells
Glaucoma is a group of ocular diseases that cause irreversible blindness. It is characterized by multifactorial degeneration of the optic nerve axons and retinal ganglion cells (RGCs), resulting in the loss of vision.
Seunghwan Choi, Soo-Ho Choi, Tonking Bastola, Younggun Park, Jonghyun Oh, Keun-Young Kim, Sinwoo Hwang, Yury I. Miller, Won-Kyu Ju   +8 more
doaj   +1 more source

Full-Length Structural Modeling of Mitofusins with AlphaFold Reveals a Novel Cross-Type Dimerization and Insights into Oligomerization

Mitochondrial dynamics, involving fission and fusion, are critical for the maintenance, function, distribution, and inheritance of mitochondria, allowing their morphology to adapt to the cell's physiological needs.
Baaden, Marc, Versini, Raphaelle, Taly, Antoine, Sub NMR Spectroscopy, Fuchs, Patrick, Bonvin, Alexandre   +5 more
core  

Genetic disruption of mitochondrial dynamics and stasis leads to liver injury and tumorigenesis

The Journal of Clinical Investigation
Mitochondrial fission is mediated by dynamin-related protein 1 (gene name DNM1L) and fusion by mitofusins (MFN1 and MFN2) and optic atrophy 1. The role of mitochondrial dynamics in liver disease and cancer remains poorly understood.
Xiaowen Ma, Xiaoli Wei, Mengwei Niu, Chen Zhang, Zheyun Peng, Wanqing Liu, Junrong Yan, Xiaoyang Su, Lichun Ma, Shaolei Lu, Wei Cui, Hiromi Sesaki, Wei-Xing Zong, Hong-Min Ni, Wen-Xing Ding   +14 more
doaj   +1 more source

Mitofusin Disease Variant Provides Insight into Mitochondrial Tethering and Fusion

, 2021
Thesis (Ph.D.)--University of Washington, 2021Mitochondria are dynamic organelles that produce the energy we need to move, grow, and think. Every cell, from muscles in the heart to neurons in the brain, has a unique and ever-changing requirement for ...
Sloat, Stephanie Rene
core  

Mitofusin 1 in mitochondrial quality control and anti-inflammatory responses in nucleus pulposus cells during disc degeneration

Scientific Reports
Mitochondrial dysfunction drives intervertebral disc degeneration, and mitochondrial dynamics are regulated by mitofusins (MFNs). In this study, we evaluated the roles of MFN1 and MFN2 in mitochondrial quality control and their responses to inflammation ...
Jae Won Shin, Young Mi Kang, Hak Sun Kim, Seong Hwan Moon, Kyung Soo Suk, Si Young Park, Byung Ho Lee, Ji Won Kwon   +7 more
doaj   +1 more source

Control of mitochondrial dynamics by a fusogenic lipid. [PDF]

Trends Cell Biol, 2023
Yang Z, Chan DC.
europepmc   +1 more source

Mitofusin MFN2 acts as a molecular sensor preventing protein aggregation and mitophagy, with a protective effect against apoptosis in Charcot-Marie-Tooth type 2A disease. [PDF]

Autophagy Rep
Joaquim M, Dohrn MF, Chevrollier A, Escobar-Henriques M.   +3 more
europepmc   +1 more source

Targeting Mitochondrial Dynamics in VEGFR-TKI Hypertension and Cardiotoxicity. [PDF]

Hypertension
Jankauskas SS, Kansakar U, Mone P, Pande S, Varzideh F, Santulli G.   +5 more
europepmc   +1 more source

Lipidomics Based on HILIC-ESI-HRMS Reveal Subtle Changes in the Mitochondrial Phospholipidome of Mouse Embryonic Fibroblasts Expressing Pathogenic Variants of Human OPA1 Protein. [PDF]

Molecules
Castellaneta A, Losito I, Porcelli V, Barile S, Maresca A, Del Dotto V, Magnoni P, Zanna C, Guadalupi LS, Cinquepalmi V, Calvano CD, Chan DC, Carelli V, Palmieri L, Cataldi TRI.   +14 more
europepmc   +1 more source