Results 71 to 80 of about 3,343 (171)
Cell Reports, 2018 Summary: Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors.
Tatiana Trevisan +5 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo +4 more
wiley +1 more source
Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases
Antioxidants, 2017 Neurodegenerative diseases are incurable and devastating neurological disorders characterized by the progressive loss of the structure and function of neurons in the central nervous system or peripheral nervous system.
Ju Gao +5 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley +1 more source
Expression of Mitofusins in non-small cell lung cancer
, 2014 粒線體構形上的動態平衡 (分裂及融合)，對於許多細胞功能都有關鍵性的影響。粒線體融合能促使不同粒線體個體間基因的交換，對於細胞的老化、生長、減少能量浪費及維持粒線體DNA的遺傳完整性都相當重要。粒線體融合蛋白Mitofusins位於粒線體外膜上，在哺乳動物細胞中已被證明是負責粒線體融合的關鍵分子，且具有維持細胞生長發育的重要功能。然而是否對於癌細胞有相同的影響，目前仍未知。本研究著重探討mitofusins在非小細胞肺癌病患中的表現情形。我們以RT-PCR及原位雜交的方法 ...
林美瑤, Lin, Mei-Yao
core
Mitofusins: Mighty Regulators of Metabolism [PDF]
, 2013 Mitochondria are central regulators of cellular metabolism but how their function in a subset of cells affects whole-body energy balance is less understood.
Ozcan, Umut
core +1 more source
Optimal timing to assess exercise‐induced oxidative stress: A systematic review and meta‐analysis
Experimental Physiology, EarlyView.Abstract There is a lack of consensus on optimal timing to assess redox biomarkers post‐exercise, limiting methodological standardisation and linking oxidative stress to physiology. We determined optimal post‐exercise oxidative stress assessment times using three redox biomarkers: glutathione, F2‐isoprostanes and protein carbonyls.
Chrysovalantis Stachteas +12 more
wiley +1 more source
Respiratory chain complexes in dynamic mitochondria display a patchy distribution in life cells [PDF]
, 2010 Background: Mitochondria, the main suppliers of cellular energy, are dynamic organelles that fuse and divide frequently. Constraining these processes impairs mitochondrial is closely linked to certain neurodegenerative diseases.
Strecker, V. +23 more
core +2 more sources
One day of environment‐induced heat stress causes injury to the murine kidney
Experimental Physiology, EarlyView.Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths +3 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova +6 more
wiley +1 more source