Results 61 to 70 of about 2,978 (195)
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
Nature Communications, 2019 Mitochondria of alveolar type 2 epithelial cells (AEC2) in the lung have been suggested to play a role in the development of idiopathic pulmonary fibrosis (IPF).
Kuei-Pin Chung +13 more
doaj +1 more source
eLife, 2014 Mitochondrial fusion and fission affect the distribution and quality control of mitochondria. We show that Marf (Mitochondrial associated regulatory factor), is required for mitochondrial fusion and transport in long axons.
Hector Sandoval +14 more
doaj +1 more source
Downregulation of Mitofusin 2 in Placenta Is Related to Preeclampsia [PDF]
BioMed Research International, 2016 Background. Mitofusin 2 (Mfn2) is a novel mitochondrial protein that is implicated in cellular proliferation and metabolism; however, the role of Mfn2 in preeclampsia (PE) remains unknown. This study aimed to explore the relationship between Mfn2 and PE.Method. Preeclamptic and normal pregnancies were enrolled in a comparative study.
Yu, Jun +3 more
openaire +2 more sources
Biomolecules, 2023 Mitochondria are highly dynamic organelles that constantly undergo fusion and fission events to maintain their shape, distribution and cellular function.
Anaïs Vlieghe +5 more
doaj +1 more source
Journal of the Peripheral Nervous System, 2023 AbstractBackground and aimsMitofusin 1 (MFN1) and MFN2 are outer mitochondrial membrane fusogenic proteins regulating mitochondrial network morphology. MFN2 mutations cause Charcot‐Marie‐Tooth type 2A (CMT2A), an axonal neuropathy characterized by mitochondrial fusion defects, which in the case of a GTPase domain mutant, were rescued following wild ...
Filippos Stavropoulos +6 more
openaire +2 more sources
Redox Biology, 2019 Being an assembly of protein machines, cells depend on adequate supply of energetic molecules for retaining their homeodynamics. Consequently, mitochondria functionality is ensured by quality control systems and mitochondrial dynamics (fusion/fission ...
Sentiljana Gumeni +4 more
doaj +1 more source
The role of the mitofusins in adipose tissue
, 2022 Monogenic mitochondrial disease is known to cause tissue-selective manifestations, typically affecting the nervous system, liver, and muscle. However, until recently, there was relatively little human genetic evidence for a role of mitochondria in disorders of energy balance (i.e. weight) or insulin action. Several groups have identified that biallelic
openaire +1 more source
The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors. [PDF]
PLoS ONE, 2017 Mitochondria are essential, dynamic organelles that respond to a number of stressors with changes in morphology that are linked to several mitochondrial functions, though the mechanisms involved are poorly understood.
Laura E Newman +3 more
doaj +1 more source
Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation
Life Science Alliance, 2020 Mitochondrial fusion requires a conformational change in α4 of the GTPase domain, followed by AAA-ATPase regulation, thus revealing striking mechanistic similarities between small and large GTPases. Mitochondria are essential organelles whose function is
Ramona Schuster +10 more
doaj +1 more source
LncRNA ANRIL mediates endothelial dysfunction through BDNF downregulation in chronic kidney disease
Cell Death and Disease, 2022 Endothelial dysfunction is common in patients with chronic kidney disease (CKD), but the mechanism is unknown. In this study, we found that the circulating ANRIL level was increased and correlated with vascular endothelial dysfunction in patients with ...
Hong Su +10 more
doaj +1 more source