Results 61 to 70 of about 3,343 (171)

Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation

Life Science Alliance, 2020
Mitochondrial fusion requires a conformational change in α4 of the GTPase domain, followed by AAA-ATPase regulation, thus revealing striking mechanistic similarities between small and large GTPases. Mitochondria are essential organelles whose function is
Ramona Schuster, Vincent Anton, Tânia Simões, Selver Altin, Fabian den Brave, Thomas Hermanns, Manuela Hospenthal, David Komander, Gunnar Dittmar, R Jürgen Dohmen, Mafalda Escobar-Henriques   +10 more
doaj   +1 more source

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors. [PDF]

PLoS ONE, 2017
Mitochondria are essential, dynamic organelles that respond to a number of stressors with changes in morphology that are linked to several mitochondrial functions, though the mechanisms involved are poorly understood.
Laura E Newman, Cara R Schiavon, Chengjing Zhou, Richard A Kahn   +3 more
doaj   +1 more source

LncRNA ANRIL mediates endothelial dysfunction through BDNF downregulation in chronic kidney disease

Cell Death and Disease, 2022
Endothelial dysfunction is common in patients with chronic kidney disease (CKD), but the mechanism is unknown. In this study, we found that the circulating ANRIL level was increased and correlated with vascular endothelial dysfunction in patients with ...
Hong Su, Bing Liu, Huimin Chen, Tingwei Zhang, Tongtong Huang, Yue Liu, Cheng Wang, Qiqi Ma, Qianhui Wang, Zhimei Lv, Rong Wang   +10 more
doaj   +1 more source

Mitophagy, Mitochondrial Homeostasis, and Cell Fate

Frontiers in Cell and Developmental Biology, 2020
Mitochondria are highly plastic and dynamic organelles that have graded responses to the changing cellular, environmental, and developmental cues. Mitochondria undergo constant mitochondrial fission and fusion, mitochondrial biogenesis, and mitophagy ...
Kaili Ma, Guo Chen, Wenhui Li, Oliver Kepp, Oliver Kepp, Yushan Zhu, Quan Chen   +6 more
doaj   +1 more source

Physics-based oligomeric models of the yeast mitofusin Fzo1 at the molecular scale in the context of membrane docking [PDF]

, 2019
Tethering and homotypic fusion of mitochondrial outer membranes is mediated by large GTPases of the dynamin-related proteins family called the mitofusins.
Baaden, Marc, Cohen, Mickaël,, Cohen, MM, Baaden, M, Brandner, Astrid, Brandner, A, Taly, A, TALY, Antoine, De Vecchis, D, De Vecchis, Dario   +9 more
core   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Fish oil and omega3 in the prevention of metabolic disorders linked to obesity: role of mitochondrial function [PDF]

, 2011
Obesity is one of the most serious public health problems of the 21st century. Along with the increase in obesity, there is a parallel increase in the prevalence of type 2 diabetes, impaired glucose tolerance, atherogenic dyslipidemia (high plasma ...
Pignalosa, Angelica
core   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source