MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion [PDF]
, 2017 Mitochondria are double-membraned organelles with variable shapes influenced by metabolic conditions, developmental stage, and environmental stimuli. Their dynamic morphology is a result of regulated and balanced fusion and fission processes.
A Franco +61 more
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Mitophagy: Mitofusin Recruits a Mitochondrial Killer [PDF]
Current Biology, 2013 Parkin is a cytosolic ubiquitin ligase that translocates to damaged mitochondria and promotes their degradation. Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin translocation to damaged mitochondria.
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Mitochondrial Fragmentation Due to Inhibition of Fusion Increases Cyclin B through Mitochondrial Superoxide Radicals. [PDF]
PLoS ONE, 2015 During the cell cycle, mitochondria undergo regulated changes in morphology. Two particularly interesting events are first, mitochondrial hyperfusion during the G(1)-S transition and second, fragmentation during entry into mitosis.
Tejas M Gupte
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RBR E3 ubiquitin ligases: new structures, new insights, new questions [PDF]
, 2014 The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes.
Shaw, Gary S. +2 more
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Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition
Life Science Alliance, 2019 Mitochondrial fusion requires an alternating salt bridge between CMT2A-associated disease residues that enable GTP hydrolysis; Fzo1 ubiquitylation then licenses post-fusion recycling by Cdc48.
Vincent Anton +9 more
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Biology, 2023 Mitochondrial fission and fusion are required for maintaining functional mitochondria. The mitofusins (MFN1 and MFN2) are known for their roles in mediating mitochondrial fusion.
Timothy J. Hines +8 more
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Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction [PDF]
, 2016 Mitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as the sarcoplasmic reticulum (SR).
Burke, N +8 more
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Mitochondrial fusion: Reaching the end of mitofusin’s tether [PDF]
Journal of Cell Biology, 2016 In this issue, Qi et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201609019) provide structural insights into the mechanisms of mitochondrial outer membrane fusion by investigating the structure of mitofusin 1 (MFN1). This work proposes a new model to explain the important and elusive process of MFN-mediated mitochondrial fusion.
Formosa, Luke E., Ryan, Michael T.
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RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Trans-mitochondrial coordination of cristae at regulated membrane junctions [PDF]
, 2015 Reminiscent of bacterial quorum sensing, mammalian mitochondria participate in inter-organelle communication. However, physical structures that enhance or enable interactions between mitochondria have not been defined.
A Kasahara +44 more
core +2 more sources