Results 141 to 150 of about 5,369 (241)

Heme Metabolism‐Derived Carbon Monoxide Regulates Skeletal Muscle Function

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Heme oxygenases, HO‐1 (Hmox1) and HO‐2 (Hmox2), regulate skeletal muscle homeostasis by degrading heme and generating carbon monoxide (CO), a bioactive signalling molecule. Although HO‐1 is known to influence muscle fibre composition and mitochondrial function, the role of HO‐2 in activity‐dependent neuromuscular plasticity remains ...
Rodrigo W. Alves de Souza, Hyo In Kim, Paula Ketilly Nascimento Alves, Ailma Oliveira da Paixão, Ashlee Rasmussen, Sidharth Shankar, James Harbison, Vanessa Azevedo Voltarelli, Leo E. Otterbein   +8 more
wiley   +1 more source

AIBP: A New Safeguard against Glaucomatous Neuroinflammation

Cells
Glaucoma is a group of ocular diseases that cause irreversible blindness. It is characterized by multifactorial degeneration of the optic nerve axons and retinal ganglion cells (RGCs), resulting in the loss of vision.
Seunghwan Choi, Soo-Ho Choi, Tonking Bastola, Younggun Park, Jonghyun Oh, Keun-Young Kim, Sinwoo Hwang, Yury I. Miller, Won-Kyu Ju   +8 more
doaj   +1 more source

Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization. [PDF]

, 2019
Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known.
Ahn, Sangphil, Edwards, Genea, Ju, Won-Kyu, Kim, Keun-Young, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +6 more
core   +1 more source

Mitochondrial reprogramming in lung cancer: a therapeutic vulnerability and a strategy for reversing drug resistance

The Journal of Pathology, Volume 269, Issue 2, Page 149-163, June 2026.
Abstract The conceptualization of mitochondria, previously restricted to their function as cellular ‘powerhouses’, has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and fate determination.
Woo Hyun Park
wiley   +1 more source

Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial Infarction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Myocardial infarction (MI) is one of the leading causes of death worldwide. MI is associated with cardiac structural and functional alterations. Among these, cardiac fibrosis may be significantly influenced by mitochondrial dysfunction. We sought to evaluate whether the injection of functional mitochondria from healthy muscle could improve
María Cuesta‐Corral, Alejandro Montoro‐Garrido, Ana Romero‐Miranda, Fabián Islas, Bunty Ramchandani, Ricardo Gredilla, Joaquín Fernández‐Irigoyen, Enrique Santamaría, Beatriz Delgado‐Valero, Sara Jiménez‐González, Raquel Rodrigues Díez, María Luisa Nieto, Victoria Cachofeiro, Ernesto Martínez‐Martínez   +13 more
wiley   +1 more source

Control of mitochondrial dynamics by a fusogenic lipid. [PDF]

Trends Cell Biol, 2023
Yang Z, Chan DC.
europepmc   +1 more source

OPA1 in MC4R Neurons Regulates Dietary Fat Intake and Body Weight in Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Soybean oil intake induces OPA1 expression in hypothalamic MC4R neurons, contributing to adaptive regulation of appetite. MC4R neuron‐specific OPA1 deficiency increases soybean oil consumption and leads to obesity, with a more pronounced effect in females.
Shigenobu Matsumura, Mizuki Fujiwara, Soyoka Horie, Miona Marutani, Eri Nousou, Nanase Iki, Yuka Yamato, Yui Otonashi, Tsutomu Sasaki, Mina Fujitani, Teppei Fujikawa   +10 more
wiley   +1 more source

Neurodegeneration as a consequence of failed mitochondrial maintenance [PDF]

, 2018
Maintaining the functional integrity of mitochondria is pivotal for cellular survival. It appears that neuronal homeostasis depends on high-fidelity mitochondria, in particular.
Karbowski, Mariusz, Neutzner, Albert
core  

Intercompartmental communication in senescence

FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Identification of the interaction networks of Mitofusin-1 and Mitofusin-2 = Identificació de les xarxes d’interacció de Mitofusina-1 i Mitofusina-2

, 2021
Programa de Doctorat en Biomedicina / Tesi realitzada a l'Institut de Recerca Biomèdica de Barcelona (IRBB)
openaire   +2 more sources