Results 41 to 50 of about 5,278 (225)

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion [PDF]

, 2006
Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact ...
Chan, David C., Griffin, Erik E.
core   +3 more sources

Structure and function of bacterial dynamin-like proteins [PDF]

, 2012
Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core   +1 more source

Correcting mitochondrial fusion by manipulating mitofusin conformations [PDF]

Nature, 2016
Mitochondria are dynamic organelles that exchange contents and undergo remodelling during cyclic fusion and fission. Genetic mutations in MFN2 (the gene encoding mitofusin 2) interrupt mitochondrial fusion and cause the untreatable neurodegenerative condition Charcot-Marie-Tooth disease type 2A (CMT2A). It has not yet been possible to directly modulate
Antonietta, Franco, Richard N, Kitsis, Julie A, Fleischer, Evripidis, Gavathiotis, Opher S, Kornfeld, Guohua, Gong, Nikolaos, Biris, Ann, Benz, Nir, Qvit, Sara K, Donnelly, Yun, Chen, Steven, Mennerick, Louis, Hodgson, Daria, Mochly-Rosen, Gerald W, Dorn   +14 more
openaire   +2 more sources

A Novel ENU-Induced Mfn2 Mutation Causes Motor Deficits in Mice without Causing Peripheral Neuropathy

Biology, 2023
Mitochondrial fission and fusion are required for maintaining functional mitochondria. The mitofusins (MFN1 and MFN2) are known for their roles in mediating mitochondrial fusion.
Timothy J. Hines, Janice Bailey, Hedi Liu, Anyonya R. Guntur, Kevin L. Seburn, Samia L. Pratt, Jonathan R. Funke, Lisa M. Tarantino, Robert W. Burgess   +8 more
doaj   +1 more source

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis [PDF]

, 2004
A dynamic balance of organelle fusion and fission regulates mitochondrial morphology. During apoptosis this balance is altered, leading to an extensive fragmentation of the mitochondria.
Arnoult, Damien, Chan, David C., Chen, Hsuichen, Karbowski, Mariusz, Smith, Carolyn L., Youle, Richard J.   +5 more
core   +2 more sources

Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography [PDF]

, 2017
The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria-junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable
Cabrera-Fuentes, Hector, Chakraborty, Bibhas, Chinda, Kroekkiat, Cooper, Jackie, Dorn, Gerald W, II, Fan, Qiao, Hall, Andrew R, Hausenloy, Derek J, Hernandez-Resendiz, Sauri, Kalkhoran, Siavash Beikoghli, Ong, Sang-Bing, White, Ian J, Yellon, Derek M   +12 more
core   +2 more sources

Trans-mitochondrial coordination of cristae at regulated membrane junctions [PDF]

, 2015
Reminiscent of bacterial quorum sensing, mammalian mitochondria participate in inter-organelle communication. However, physical structures that enhance or enable interactions between mitochondria have not been defined.
A Kasahara, AA Amchenkova, BH Graham, C Frezza, C Garcia-Perez, CA Mannella, CA Mannella, CR Hackenbrock, CS Lin, D Dikov, DC Jans, DJ Toth, DN Mastronarde, E Braschi, F Ichas, FT Kurz, FT Kurz, G Csordas, G Csordas, J Santo-Domingo, JR Kremer, L Gammaitoni, L Zhou, M Duvert, M Picard, M Picard, M Picard, M Strauss, MV Shornikova, N Khalifat, N Pfanner, P Bhandari, P Pacher, S Cogliati, S Cortassa, SE Darch, SL Archer, T Klecker, T Shutt, VP Skulachev, WL Ng, X Huang, Y Chen, Y Chen, Y Yaniv   +44 more
core   +4 more sources

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources

Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A

eLife, 2020
Charcot–Marie-Tooth disease type 2A (CMT2A) is an untreatable childhood peripheral neuropathy caused by mutations of the mitochondrial fusion protein, mitofusin (MFN) 2.
Antonietta Franco, Xiawei Dang, Emily K Walton, Joshua N Ho, Barbara Zablocka, Cindy Ly, Timothy M Miller, Robert H Baloh, Michael E Shy, Andrew S Yoo, Gerald W Dorn II   +10 more
doaj   +1 more source

Monitoring Mitochondrial Function in Aedes albopictus C6/36 Cell Line during Dengue Virus Infection

Insects, 2021
Aedes aegypti and Aedes albopictus mosquitoes are responsible for dengue virus (DENV) transmission in tropical and subtropical areas worldwide, where an estimated 3 billion people live at risk of DENV exposure.
María E. Santana-Román, Paola Maycotte, Salvador Uribe-Carvajal, Cristina Uribe-Alvarez, Nayeli Alvarado-Medina, Mohsin Khan, Aleem Siddiqui, Victoria Pando-Robles   +7 more
doaj   +1 more source