Results 101 to 110 of about 96,831 (392)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

EMBO Reports
Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of functional mitochondria. The SCFFBXL4 ubiquitin ligase complex suppresses mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors, and FBXL4 ...
Giang Thanh Nguyen-Dien, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew JK Jones, S Sean Millard, Dominic CH Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan   +17 more
doaj   +1 more source

BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia

Cell Death and Disease, 2022
Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria.
Yun-Ling He, Jian Li, Sheng-Hui Gong, Xiang Cheng, Ming Zhao, Yan Cao, Tong Zhao, Yong-Qi Zhao, Ming Fan, Hai-Tao Wu, Ling-Ling Zhu, Li-Ying Wu   +11 more
doaj   +1 more source

Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle [PDF]

, 2019
Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which is related with poor prognosis and compromised quality of life.
Alcantara, P. S., Coletti, D., de Castro, G. S., Festuccia, W. T., Lima, J. D. C. C., Ortiz-Silva, M., Otoch, J. P., Seelaender, M., Simoes, E., Tokeshi, F.   +9 more
core   +1 more source

Mitophagy-related regulated cell death: molecular mechanisms and disease implications

Cell Death and Disease
During oxidative phosphorylation, mitochondria continuously produce reactive oxygen species (ROS), and untimely ROS clearance can subject mitochondria to oxidative stress, ultimately resulting in mitochondrial damage.
Molin Yang, Xiang Wei, Xin Yi, D. Jiang
semanticscholar   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

The landscape of mitophagy in sepsis reveals PHB1 as an NLRP3 inflammasome inhibitor

Frontiers in Immunology, 2023
Mitophagy is a selective autophagy targeting damaged and potential cytotoxic mitochondria, which can effectively prevent excessive cytotoxic production from damaged mitochondria and alleviate the inflammatory response.
Shipeng Chen, Shipeng Chen, Jinqi Ma, Ping Yin, Fang Liang   +4 more
doaj   +1 more source

Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1

Autophagy, 2023
Mitophagy, which selectively eliminates the dysfunctional and excess mitochondria by autophagy, is crucial for cellular homeostasis under stresses such as hypoxia.
Ying Liu, Hanwen Zhang, Yiwei Liu, Siyue Zhang, P. Su, Lijuan Wang, Yaming Li, Yiran Liang, Xiaolong Wang, Weijing Zhao, Bing Chen, Dan Luo, Ning Zhang, Qifeng Yang   +13 more
semanticscholar   +1 more source

Mitophagy-enhancing fatty acids attenuate LPS-induced inflammation in THP1 cells [PDF]

, 2023
Svetlana S. Verkhova, Alexander D. Zhuravlev, N. Nikiforov, Anton Y. Postnov, Y. Yegorov, Alexander N. Orekhov   +5 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source