Results 111 to 120 of about 75,749 (306)

Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection [PDF]

, 2016
Mitochondria are the foremost producers of the cellular energy currency ATP. They are also a significant source of reactive oxygen species and an important buffer of intracellular calcium.
Bingol, Caviston, Chourasia, Cui, Daniel A. East, Duchen, East, East, Fei, Feng, Gatliff, Geisler, Guardia-Laguarta, Guo, Hanna, Jain, Jin, Kamat, Kawamata, Kim, Landes, Lee, Lee, Lefebvre, Lionaki, Liu, Lokireddy, Magrané, Martinez-Vicente, Martinou, Matic, Mattiazzi, Melser, Michalik, Michelangelo Campanella, Narendra, Narendra, Orr, Padman, Palomo, Pankiv, Panov, Pickrell, Quirós, Richter, Rugarli, Ryan, Sarraf, Schwarten, Shaw, Sheng, Shin, Stafa, Stoica, Strappazzon, Subramaniam, Tanti, Tsunemi, Valente, Van Humbeeck, Vives-Bauza, Wallace, Wang, Wang, Wu, Zhang, Zhu   +66 more
core   +2 more sources

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

eLife, 2018
Mutations in the genes for PINK1 and parkin cause Parkinson’s disease. PINK1 and parkin cooperate in the selective autophagic degradation of damaged mitochondria (mitophagy) in cultured cells.
Tom Cornelissen, Sven Vilain, Katlijn Vints, Natalia Gounko, Patrik Verstreken, Wim Vandenberghe   +5 more
doaj   +1 more source

Life in lights:tracking mitochondrial delivery to lysosomes in vivo [PDF]

, 2016
The past decade has seen an intensive and concerted research effort into the molecular regulation of mitophagy, the selective autophagy of mitochondria.
Ganley, Ian G., McWilliams, Thomas G.
core   +2 more sources

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]

, 2015
No abstract ...
Alvarez-Curto, Elisa, Caltabiano, Gianluigi Caltabiano, Liste, María José Varela, Marsango, Sara, Milligan, Graeme   +4 more
core   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Progress in research on mitophagy and pulmonary diseases [PDF]

Jichu yixue yu linchuang, 2020
Mitophagy is one of the important forms of selective autophagy, which affects the occurrence and development of lung diseases by regulating the quality of mitochondria in vivo. Mitophagy has different functions in different lung diseases.
TAN Shi-Yi, CHEN Shi
doaj  

Nature‐Inspired Surface Modification Strategy Reverses the Autophagic Flux Impairment of Mitochondrial Transplantation for Attenuating Ischemic Strokes

Advanced Science, EarlyView.
The functionalized starch modifies the mitochondrial surface and encapsulates resveratrol into the cavity of helices, facilitating a novel mitochondrial transplantation platform (MLSR). Upon internalization in recipient cells, MLSR triggers mitophagy and maintains positive autophagic flux through RIP1/RIP3 pathway inhibition.
Nisha Wang, Qiyang Ding, Lei Shi, Ji Xia, Shuyue Zhang, Chenxin Jian, Yixiao Yan, Xiuhua Luo, Jiarui Wang, Ming Cheng, Yiqiong Jia, Hao Tian, Wei Gao   +12 more
wiley   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source