Results 231 to 240 of about 50,060 (264)
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Essays in Biochemistry, 2013
Mitophagy describes the selective targeting and degradation of mitochondria by the autophagy pathway. In this process, defective mitochondria are first purged from the mitochondrial network then delivered to the lysosome by the autophagy machinery.
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Mitophagy describes the selective targeting and degradation of mitochondria by the autophagy pathway. In this process, defective mitochondria are first purged from the mitochondrial network then delivered to the lysosome by the autophagy machinery.
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Mitophagy in cardiovascular disease
Clinica Chimica Acta, 2020Cardiovascular disease (CVD) leads to high morbidity and mortality rates worldwide. Accumulating evidence has revealed that mitochondria dysfunction is implicated in CVD, such as atherosclerosis (AS), hypertension, myocardial ischemia-reperfusion (MI/R) injury, myocardial infarction (MI), cardiac hypertrophy, heart failure (HF), dilated cardiomyopathy (
Hong Zhou +3 more
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Mitophagy in Yeast: A Screen of Mitophagy-Deficient Mutants
2017Mitochondrial autophagy (mitophagy) is a process that selectively degrades mitochondria via autophagy. Recent studies have shown that mitophagy plays an important role in mitochondrial homeostasis by degrading damaged or excess mitochondria. The budding yeast Saccharomyces cerevisiae is a powerful model organism that has been employed to study several ...
Kentaro, Furukawa, Tomotake, Kanki
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Mitophagy and Mitochondrial Balance
2014Mitochondria are highly dynamic organelles, with a morphology ranging from small roundish elements to large interconnected networks. This fine architecture has a significant impact on mitochondrial homeostasis, and mitochondrial morphology is highly connected to specific cellular process.
PATERGNANI, Simone, PINTON, Paolo
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Induction and Detection of Mitophagy
2022Mitophagy, a process of selective elimination of mitochondria by autophagy, is a mechanism of mitochondrial quality control that maintains mitochondrial network functionality. The elimination of damaged mitochondria through autophagy requires two steps: induction of general autophagy and priming of damaged mitochondria for selective autophagic ...
Maria A, Yapryntseva +2 more
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Alternative macroautophagy and mitophagy
The International Journal of Biochemistry & Cell Biology, 2014Mitophagy is a mitochondrial quality control mechanism where damaged and surplus mitochondria are removed by macroautophagy. Mitophagy is associated with various physiological and pathological events such as mitochondrial clearance during terminal differentiation of reticulocytes.
Shigeomi, Shimizu +3 more
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Mitophagy in aging and longevity
IUBMB Life, 2021AbstractThe clearance of damaged or unwanted mitochondria by autophagy (also known as mitophagy) is a mitochondrial quality control mechanism postulated to play an essential role in cellular homeostasis, metabolism, and development and confers protection against a wide range of diseases.
Jing Guo, Wei‐Chung Chiang
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2017
Elimination of damaged or surplus mitochondria is crucial to maintain cellular integrity and an energy supply-demand balance. Mitophagy serves to selectively catabolize mitochondria in a manner dependent on autophagy, and contributes to mitochondrial quality and quantity control.
Akinori, Eiyama, Koji, Okamoto
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Elimination of damaged or surplus mitochondria is crucial to maintain cellular integrity and an energy supply-demand balance. Mitophagy serves to selectively catabolize mitochondria in a manner dependent on autophagy, and contributes to mitochondrial quality and quantity control.
Akinori, Eiyama, Koji, Okamoto
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Parkin and mitophagy in cancer
Oncogene, 2016Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the homeostasis of a healthy network of functioning mitochondria and prevents excessive production of cytotoxic reactive oxygen species from damaged mitochondria. The mitochondrially targeted PTEN-induced kinase-1 (PINK1) and the E3 ubiquitin ligase Parkin are well ...
J P, Bernardini, M, Lazarou, G, Dewson
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Triggering Mitophagy with Photosensitizers
2019One can utilize light illumination to stimulate mitochondrial reactive oxygen species production through the use of mitochondria-specific photosensitizers. By proper tuning of the light dosage, the methodology permits probing of a multitude of mitochondrial damage responses, including mitophagy. This light-controllable trick offers unique opportunities
Cheng-Wei, Hsieh, Wei Yuan, Yang
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