Results 51 to 60 of about 96,831 (392)
Mitophagy: Permitted by Prohibitin [PDF]
Current Biology, 2017 Autophagic responses specific for damaged or superfluous mitochondria are crucial for the maintenance of cellular and organismal homeostasis. Recent data demonstrate that components of the inner mitochondrial membrane that are unmasked upon outer membrane permeabilization facilitate the autophagic destruction of the organelle.
Lorenzo, Galluzzi +2 more
openaire +2 more sources
Autophagy in DNA Damage Response [PDF]
, 2015 DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation ...
Elzbieta Pawlowska +4 more
core +5 more sources
Cells, 2019 Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein,
Alagie Jassey +5 more
doaj +1 more source
eLife, 2020 Degradation of mitochondria through mitophagy contributes to the maintenance of mitochondrial function. In this study, we identified that Atg43, a mitochondrial outer membrane protein, serves as a mitophagy receptor in the model organism ...
Tomoyuki Fukuda +8 more
doaj +1 more source
The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis [PDF]
, 2018 PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes.
Lucas, Millikin, Narendra, Santel, Zhang
core +2 more sources
Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. [PDF]
, 2014 The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens.
Anastas, Sara +9 more
core +3 more sources
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis
Cell Discovery, 2022 Ferroptosis is a regulated iron-dependent cell death characterized by the accumulation of lipid peroxidation. A myriad of facets linking amino acid, lipid, redox, and iron metabolisms were found to drive or to suppress the execution of ferroptosis ...
Fan Yu +15 more
semanticscholar +1 more source
Mitophagy in Pancreatic Cancer [PDF]
Frontiers in Oncology, 2021 Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive solid malignancies, is characterized by the presence of oncogenic KRAS mutations, poor response to current therapies, prone to metastasis, and a low 5-year overall survival rate. Macroautophagy (herein referred to as autophagy) is a lysosome-dependent degradation system that forms a ...
Yangchun Xie +3 more
openaire +3 more sources
Journal of Translational Medicine, 2020 Background We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood.
Youguang Gao +8 more
doaj +1 more source
Comparisons of ELISA and Western blot assays for detection of autophagy flux [PDF]
, 2017 We analyzed autophagy/mitophagy flux in vitro (C2C12 myotubes) and in vivo (mouse skeletal muscle) following the treatments of autophagy inducers (starvation, rapamycin) and a mitophagy inducer (carbonyl cyanide m-chlorophenylhydrazone, CCCP) using two ...
Choi, Yong-bok +4 more
core +3 more sources