Results 11 to 20 of about 229,134 (290)

53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

eLife, 2016
Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in
Chii Shyang Fong, Gregory Mazo, Tuhin Das, Joshua Goodman, Minhee Kim, Brian P O'Rourke, Denisse Izquierdo, Meng-Fu Bryan Tsou   +7 more
doaj   +2 more sources

Mitosis Counting in Breast Cancer: Object-Level Interobserver Agreement and Comparison to an Automatic Method. [PDF]

PLoS ONE, 2016
Tumor proliferation speed, most commonly assessed by counting of mitotic figures in histological slide preparations, is an important biomarker for breast cancer.
Mitko Veta, Paul J van Diest, Mehdi Jiwa, Shaimaa Al-Janabi, Josien P W Pluim   +4 more
doaj   +2 more sources

Whole-Slide Mitosis Detection in H&E Breast Histology Using PHH3 as a Reference to Train Distilled Stain-Invariant Convolutional Networks [PDF]

IEEE Transactions on Medical Imaging, 2018
Manual counting of mitotic tumor cells in tissue sections constitutes one of the strongest prognostic markers for breast cancer. This procedure, however, is time-consuming and error-prone.
David Tellez, M. Balkenhol, I. Otte-Höller, Rob van de Loo, Rob Vogels, P. Bult, C. Wauters, W. Vreuls, S. Mol, N. Karssemeijer, G. Litjens, J. A. van der Laak, F. Ciompi   +12 more
semanticscholar   +1 more source

Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization

Stem Cell Reports, 2017
The recent establishment of mammalian haploid embryonic stem cells (ESCs) provides new possibilities for genetic screening and for understanding genome evolution and function. However, the dynamics of mitosis in haploid ESCs is still unclear.
Ao Guo, Shichao Huang, Jiali Yu, Huihan Wang, Haisen Li, Gang Pei, Li Shen   +6 more
doaj   +1 more source

Automated mitosis detection using texture, SIFT features and HMAX biologically inspired approach

Journal of Pathology Informatics, 2013
Context: According to Nottingham grading system, mitosis count in breast cancer histopathology is one of three components required for cancer grading and prognosis. Manual counting of mitosis is tedious and subject to considerable inter- and intra-reader
Humayun Irshad, Sepehr Jalali, Ludovic Roux, Daniel Racoceanu, Lim Joo Hwee, Gilles Le Naour, Frédérique Capron   +6 more
doaj   +1 more source

Mitosis Methods & Protocols

European Journal of Histochemistry, 2010
Mitosis Methods & Protocols Andrew D. McAinsh (Edt) Humana press, Totowa, New Jersey (USA) Series: Springer Protocols Methods in Molecular Biology, Volume 545, 2009 ISBN: 978-1-60327-992-5   It is quite clear from the contents of this book that
CarloAlberto Redi
doaj   +1 more source

Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation

Open Biology, 2022
Lamin A phosphorylation/de-phosphorylation is an important process during cells division as it allows for nuclear envelope (NE) disassembly at mitotic entry and its re-assembly during mitotic exit.
Florentin Huguet, Ezgi Gokhan, Helen A. Foster, Hasnat A. Amin, Paola Vagnarelli   +4 more
doaj   +1 more source

H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

bioRxiv, 2019
Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the
A. Poleshko, Cheryl L Smith, S. Nguyen, Priya Sivaramakrishnan, J. Murray, M. Lakadamyali, E. Joyce, Rajan Jain, J. Epstein   +8 more
semanticscholar   +1 more source

Automated mitosis detection in histopathology using morphological and multi-channel statistics features

Journal of Pathology Informatics, 2013
Context: According to Nottingham grading system, mitosis count plays a critical role in cancer diagnosis and grading. Manual counting of mitosis is tedious and subject to considerable inter- and intra-reader variations.
Humayun Irshad
doaj   +1 more source

Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis

Science Signaling, 2018
Precise spatiotemporal control enables the mitotic kinases Aurora and PLK1 to orchestrate distinct mitotic processes. Gloss Ever since its first observation under the microscope over a century ago, mitosis—the process wherein a cell divides into two ...
V. Joukov, A. De Nicolo
semanticscholar   +1 more source