eLife, 2016 Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in
C. S. Fong +7 more
semanticscholar +3 more sources
Mitosis Counting in Breast Cancer: Object-Level Interobserver Agreement and Comparison to an Automatic Method [PDF]
PLoS ONE, 2016 Background Tumor proliferation speed, most commonly assessed by counting of mitotic figures in histological slide preparations, is an important biomarker for breast cancer. Although mitosis counting is routinely performed by pathologists, it is a tedious
M. Veta +4 more
semanticscholar +2 more sources
Regulation of mRNA translation during mitosis
eLife, 2015 Passage through mitosis is driven by precisely-timed changes in transcriptional regulation and protein degradation. However, the importance of translational regulation during mitosis remains poorly understood. Here, using ribosome profiling, we find both
M. Tanenbaum +3 more
semanticscholar +3 more sources
Mitosis detection in histopathological images using customized deep learning and hybrid optimization algorithms. [PDF]
PLoS OneIdentifying mitosis is crucial for cancer diagnosis, but accurate detection remains difficult because of class imbalance and complex morphological variations in histopathological images.
Alhassan AM, Altmami NI.
europepmc +2 more sources
Contextual Prior Constrained Deep Networks for Mitosis Detection With Point Annotations
IEEE Access, 2021 We study the problem of training an accurate deep learning mitosis detection model with only point annotations. To address this challenging label-efficient deep learning problem, we propose a novel contextual prior constraint mechanism and spatial area ...
Jiangxiao Han, Xinggang Wang, Wenyu Liu
doaj +1 more source
Turning end-joining upside down in mitosis
Molecular & Cellular Oncology, 2021 How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions.
Marta Llorens-Agost +4 more
doaj +1 more source
Assessment of algorithms for mitosis detection in breast cancer histopathology images [PDF]
Medical Image Anal., 2014 The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers.
M. Veta +28 more
semanticscholar +8 more sources
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. [PDF]
PLoS ONE, 2011 Entry into and progression through mitosis depends on phosphorylation and dephosphorylation of key substrates. In yeast, the nucleolar phosphatase Cdc14 is pivotal for exit from mitosis counteracting Cdk1-dependent phosphorylations.
Indra Tumurbaatar +4 more
doaj +1 more source
SmallMitosis: Small Size Mitotic Cells Detection in Breast Histopathology Images
IEEE Access, 2021 Mitotic figure count acts as a proliferative marker to measure aggressiveness of the breast cancer tumor. In this article, we have proposed a novel framework named SmallMitosis to detect mitotic cells particularly very small size mitosis from hematoxylin
Tasleem Kausar +3 more
doaj +1 more source
Anti-tumor pharmacology of natural products targeting mitosis
Cancer Biology & Medicine, 2022 Cancer has been an insurmountable problem in the history of medical science. The uncontrollable proliferation of cancer cells is one of cancer’s main characteristics, which is closely associated with abnormal mitosis.
Manru Huang +7 more
doaj +1 more source