Results 41 to 50 of about 286,319 (230)
Simple geometric mitosis [PDF]
arXiv, 2022 We construct simple geometric operations on faces of the Cayley sum of two polytopes. These operations can be thought of as convex geometric counterparts of divided difference operators in Schubert calculus. We show that these operations give a uniform construction of Knutson-Miller mitosis (in type A) and (simplified) Fujita mitosis (in type C) on ...
arxiv
Exotic mitotic mechanisms [PDF]
, 2012 The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
core +1 more source
Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression
eLife, 2015 During cell division, progression through mitosis is driven by a protein phosphorylation wave. This wave namely depends on an activation-inactivation cycle of cyclin B-dependent kinase (Cdk) 1 while activities of major protein phosphatases, like PP1 and ...
Rosa Della Monica +4 more
doaj +1 more source
Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis [PDF]
, 2013 Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in the dogma that translation rates are slowed during mitosis, with cap-independent translation mechanisms favored to give expression of key ...
Abbie Mead +55 more
core +1 more source
The Biochemistry of Mitosis [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 In this article, we will discuss the biochemistry of mitosis in eukaryotic cells. We will focus on conserved principles that, importantly, are adapted to the biology of the organism. It is vital to bear in mind that the structural requirements for division in a rapidly dividing syncytial Drosophila embryo, for example, are markedly different from those
Jonathon Pines, Samuel Wieser
openaire +3 more sources
Quantitative analysis of chromatin compaction in living cells using FLIM-FRET [PDF]
, 2009 FRET analysis of cell lines expressing fluorescently tagged histones on separate nucleosomes demonstrates that variations in chromosome compaction occur during ...
Angus I. Lamond +52 more
core +4 more sources
eLife, 2016 Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in
Chii Shyang Fong +7 more
doaj +1 more source
No Provisioned Concurrency: Fast RDMA-codesigned Remote Fork for Serverless Computing [PDF]
arXiv, 2022 Serverless platforms essentially face a tradeoff between container startup time and provisioned concurrency (i.e., cached instances), which is further exaggerated by the frequent need for remote container initialization. This paper presents MITOSIS, an operating system primitive that provides fast remote fork, which exploits a deep codesign of the OS ...
arxiv
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]
, 2019 Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G. +5 more
core +2 more sources
Mitosis Detection, Fast and Slow: Robust and Efficient Detection of Mitotic Figures [PDF]
arXiv, 2022 Counting of mitotic figures is a fundamental step in grading and prognostication of several cancers. However, manual mitosis counting is tedious and time-consuming. In addition, variation in the appearance of mitotic figures causes a high degree of discordance among pathologists.
arxiv