Results 41 to 50 of about 225,726 (354)
Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis
Nature, 2016 The orientation of cell division along the long axis of the interphase cell—the century-old Hertwig’s rule—has profound roles in tissue proliferation, morphogenesis, architecture and mechanics.
Floris Bosveld +12 more
semanticscholar +1 more source
Phosphatases in Mitosis: Roles and Regulation
Biomolecules, 2019 Mitosis requires extensive rearrangement of cellular architecture and of subcellular structures so that replicated chromosomes can bind correctly to spindle microtubules and segregate towards opposite poles.
Margarida Moura, Carlos Conde
semanticscholar +1 more source
EWSR1 prevents the induction of aneuploidy through direct regulation of Aurora B
Frontiers in Cell and Developmental Biology, 2023 EWSR1 (Ewing sarcoma breakpoint region 1) was originally identified as a part of an aberrant EWSR1/FLI1 fusion gene in Ewing sarcoma, the second most common pediatric bone cancer.
Haeyoung Kim +4 more
doaj +1 more source
CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast
Biology Open, 2019 Microtubules in the mitotic spindle are organised by microtubule-associated proteins. In the late stage of mitosis, spindle microtubules are robustly organised through bundling by the antiparallel microtubule bundler Ase1/PRC1. In early mitosis, however,
Hirohisa Ebina, Liang Ji, Masamitsu Sato
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Mechanisms of Chromosome Congression during Mitosis
Biology, 2017 Chromosome congression during prometaphase culminates with the establishment of a metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more than 100 years of research on this topic have attempted to explain chromosome ...
H. Maiato +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Recent Research Advances in Mitosis during Mammalian Gametogenesis
Cells, 2019 Mitosis is a highly sophisticated and well-regulated process during the development and differentiation of mammalian gametogenesis. The regulation of mitosis plays an essential role in keeping the formulation in oogenesis and gametogenesis.
Jia-Hao Wang +5 more
doaj +1 more source
A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis
Journal of Cell Biology, 2016 Lambrus et al. show that centrosome loss or a prolonged mitosis activates a USP28–53BP1–p53–p21 signaling axis that prevents the growth of cells with an increased propensity for mitotic errors.
Bramwell G. Lambrus +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source