Results 41 to 50 of about 229,134 (290)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Mitosis detection in histopathological images using customized deep learning and hybrid optimization algorithms.

PLoS ONE
Identifying mitosis is crucial for cancer diagnosis, but accurate detection remains difficult because of class imbalance and complex morphological variations in histopathological images.
Afnan M Alhassan, Nouf I Altmami
doaj   +1 more source

Phosphorylation of the Proapoptotic BH3-Only Protein Bid Primes Mitochondria for Apoptosis during Mitotic Arrest

Cell Reports, 2014
Mitosis is a moment of exquisite vulnerability for a metazoan cell. Failure to complete mitosis accurately can lead to aneuploidy and cancer initiation.
Pengbo Wang, Jennefer Lindsay, Thomas W. Owens, Ewa J. Mularczyk, Stacey Warwood, Fiona Foster, Charles H. Streuli, Keith Brennan, Andrew P. Gilmore   +8 more
doaj   +1 more source

Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1

eLife, 2020
The inner nuclear membrane is functionalized by diverse transmembrane proteins that associate with nuclear lamins and/or chromatin. When cells enter mitosis, membrane-chromatin contacts must be broken to allow for proper chromosome segregation; yet how ...
Naemi Luithle, Jelmi uit de Bos, Ruud Hovius, Daria Maslennikova, Renard TM Lewis, Rosemarie Ungricht, Beat Fierz, Ulrike Kutay   +7 more
doaj   +1 more source

Comprehensive bioinformatics analysis reveals the prognostic value, predictive value, and immunological roles of ANLN in human cancers

Frontiers in Genetics, 2022
Anillin (ANLN) is a unique scaffolding, actin-binding protein, which is essential for the integrity and ingression of the cleavage furrow. It is mainly involved in the cytokinesis process, while its role in various tumors has not been fully addressed and
Zhiwei Cui, Jiantao Mo, Ping Song, Lijun Wang, Rongli Wang, Feiyan Cheng, Lihui Wang, Fan Zou, Xin Guan, Nini Zheng, Xinyuan Yang, Wei Wang   +11 more
doaj   +1 more source

A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

Journal of Cell Biology, 2016
Lambrus et al. show that centrosome loss or a prolonged mitosis activates a USP28–53BP1–p53–p21 signaling axis that prevents the growth of cells with an increased propensity for mitotic errors.
Bramwell G. Lambrus, V. Daggubati, Yumi Uetake, Phillip Scott, Kevin M. Clutario, G. Sluder, A. Holland   +6 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Heat stress responses vary during floret development in European spring barley cultivars

Frontiers in Plant Science, 2023
The Poaceae, or grasses, include many agriculturally important cereal crops such as rice (Oryza sativa), maize (Zea mays), barley (Hordeum vulgare) and bread wheat (Triticum aestivum). Barley is a widely grown cereal crop used for stock feed, malting and
Cindy Callens, Cindy Callens, José Fernandez-Goméz, Matthew R. Tucker, Dabing Zhang, Dabing Zhang, Zoe A. Wilson   +6 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Protein phosphatases in the regulation of mitosis

Journal of Cell Biology, 2018
Nilsson reviews the essential role of phosphoprotein phosphatases in the regulation of controlled dephosphorylation during cell division.
J. Nilsson
semanticscholar   +1 more source