Results 111 to 120 of about 205,638 (297)
Microtubule Destabilizing Kinesins: A Historical Perspective and Thoughts for the Future
Cytoskeleton, EarlyView.ABSTRACT The microtubule cytoskeleton plays critical roles in multiple cellular processes such as mitotic spindle assembly and chromosome segregation. Cells contain a number of microtubule‐associated proteins that regulate microtubule dynamics both temporally and spatially in cells. The microtubule depolymerizing kinesins include members of the Kinesin‐
Claire E. Walczak
wiley +1 more source
Scientific Reports, 2018 Precise mitotic spindle orientation is essential for both cell fate and tissue organization while defects in this process are associated with tumorigenesis and other diseases.
Barbara Vodicska +3 more
doaj +1 more source
eLife, 2016 The spindle position checkpoint (SPOC) is a spindle pole body (SPB, equivalent of mammalian centrosome) associated surveillance mechanism that halts mitotic exit upon spindle mis-orientation.
Yuliya Gryaznova +4 more
doaj +1 more source
Assembly and Maintenance of Myofibrils in the Heart
Cytoskeleton, EarlyView.ABSTRACT The assembly of actin and myosin to the paracrystalline arrangement of myofibrils in striated muscle, that is, heart and skeletal, has puzzled many a cell biologist. Different models, based on cultured cardiomyocytes, were proposed for the last 30 years to explain the sequence of events.
Elisabeth Ehler
wiley +1 more source
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]
, 1998 Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M. +23 more
core +1 more source
Diagnostic Cytopathology, EarlyView.ABSTRACT Background Primary pulmonary mesenchymal neoplasms with EWSR1::CREM fusion are rare. These lesions are challenging to diagnose by morphology and immunohistochemistry alone. Case A 66‐year‐old woman (ex‐smoker) was found to have a 1.3‐cm right lower lobe lung nodule that had grown very slowly over a 9‐year period.
Priya Upadhyay +2 more
wiley +1 more source
Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]
, 2011 Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Robert A. Cross +5 more
core +1 more source
Epithelioid Enigma: Proximal‐Type Epithelioid Sarcoma in Cyst Fluid Cytology
Diagnostic Cytopathology, EarlyView.ABSTRACT Epithelioid sarcoma (ES) is a rare, aggressive soft tissue malignancy with substantial morphologic overlap with other epithelioid neoplasms, creating diagnostic difficulty in cytology specimens. We report proximal‐type ES identified in cyst fluid from a lesion clinically interpreted as an epidermal inclusion cyst or abscess.
Nathan McGrath +2 more
wiley +1 more source
New Roles of Chk1 in Spindle Formation and Genome Integrity
BiologyDuring mitosis sister chromatids are accurately segregated into two daughter cells through a microtubule-based structure known as the mitotic spindle. Errors in mitotic spindle formation have been associated with human diseases and tumorigenesis.
Sofia Balafouti +2 more
doaj +1 more source
EMBO Molecular Medicine, 2016 The mitotic spindle assembly checkpoint (SAC) maintains genome stability and marks an important target for antineoplastic therapies. However, it has remained unclear how cells execute cell fate decisions under conditions of SAC‐induced mitotic arrest ...
Katharina Engel +22 more
doaj +1 more source