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Molecular components of the mitotic spindle
BioEssays, 1992AbstractMitotic spindles constitute the machinery responsible for equidistribution of the genetic material into each daughter cell during cell division. They are transient and hence quite labile structures, changing their morphology even while performing their function. Biochemical, immunological and genetic analyses of mitotic cells have allowed us to
R, Kuriyama, C, Nislow
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Polarity of microtubules of the mitotic spindle
Journal of Molecular Biology, 1978Abstract Microtubules are polar structures that grow preferentially at one end. Measurement of their rate of directional growth can be used as a polarity indicator to determine their orientation with respect to a nucleation site. The results are interpreted to signify that the microtubules originating from the centrosomes and chromosomes of the ...
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The regulation of mitotic spindle function
Biochemistry and Cell Biology, 1988The process of mitosis includes a series of morphological changes in the cell in which the directional movements of chromosomes are the most prominent. The presence of a microtubular array, known as the spindle or mitotic apparatus, provides at least a scaffold upon which these movements take place.
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Mitotic spindle: Focus on the function of huntingtin
The International Journal of Biochemistry & Cell Biology, 2011Mitotic spindle assembly and orientation are tightly regulated to allow the appropriate segregation of genetic material and cell fate determinants during symmetric and asymmetric divisions. Microtubules and many proteins including the dynein/dynactin complex and the large nuclear mitotic apparatus NuMA protein, are fundamental players in these ...
Godin, Juliette, Humbert, Sandrine
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Mitotic spindle pole separation
Trends in Cell Biology, 1993Eukaryotic cells utilize a microtubular spindle to segregate chromosomes during mitosis. Chromosome segregation requires the timely separation of the mitotic spindle poles to which the chromosomes are attached. Recent studies at the molecular and cellular levels have provided new insights into the mechanism and regulation of this process.
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Mitotic Spindle Dynamics in Drosophila
2007Mitosis, the process by which the replicated chromosomes are segregated equally into daughter cells, has been studied for over a century. Drosophila melanogaster is an ideal organism for this research. Drosophila embryos are well suited to image mitosis, because during cycles 10-13 nuclei divide rapidly at the surface of the embryo, but mitotic cells ...
Ingrid, Brust-Mascher +1 more
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Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning
Proceedings of the National Academy of Sciences of the United States of America, 2022Javad Najafi +2 more
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