Results 121 to 130 of about 2,942 (230)

Synthesis of Analogues Based on the Opioid Alkaloid Mitragynine [PDF]

, 2010
Opioid analgesics such as morphine and its derivatives are the most frequently prescribed narcotics for the treatment of severe and chronic pain. Among other side effects caused by the administration of these opioid analgesics, physical dependence and ...
Arribas, Marco A
core   +1 more source

Dual anti-inflammatory activities of COX-2/5-LOX driven by kratom alkaloid extracts in lipopolysaccharide-induced RAW 264.7 cells

Scientific Reports
Cyclooxygenase (COX) and lipoxygenase (LOX) enzymes play a pivotal role in producing pro-inflammatory eicosanoids, including prostaglandins (PGs) and leukotrienes (LTs), in the inflammation process.
Siti Irma Rahmawati, Dwi Wahyu Indriani, Febby Nurdiya Ningsih, Mutia Hardhiyuna, Firdayani Firdayani, Peni Ahmadi, A’liyatur Rosyidah, Eris Septiana, Ni Luh Putu Indi Dharmayanti, Asep Bayu, Masteria Yunovilsa Putra   +10 more
doaj   +1 more source

A Review on Isolation, Characterization, Biosynthesis, Synthesis, Modification, Pharmacological Activities and Toxicology of Mitragynine

GAZI UNIVERSITY JOURNAL OF SCIENCE
Mitragynine is a natural compound found in the leaves of the mitragyna speciosa tree, commonly known as kratom, which is primarily sourced from Southeast Asia.
Susi Kusumaningrum, Teni Ernawati, F. Hermawan   +2 more
semanticscholar   +1 more source

Optimizing ultrasound-assisted extraction for enhanced quantification of 7-hydroxymitragynine and mitragynine in kratom

Creative Science
This study focuses on optimizing the extraction of two key alkaloids, mitragynine and 7-hydroxy mitragynine, from kratom (Mitragyna speciosa) leaves using ultrasound-assisted extraction (UAE).
S. Chumanee, Jirawan Thunta, Ruchira Khoomsab, Chanakan Winyakul   +3 more
semanticscholar   +1 more source

Evaluating preference-seeking and aversive qualities of Salvia divinorumand Mitragyna speciosa [PDF]

, 2013
Use of botanicals for self-diagnosed conditions or recreational purposes is increasing. Many readily available botanicals are under-researched and little is known about potential liabilities. This study sought to utilize Conditioned Place Preference (CPP)
Loria, Melissa Jane
core   +1 more source

Comparative Analysis of Mitragynine Content in Kratom Leaves (Mitragyna speciosa Korth) from Kabupaten Kapuas Hulu Using HPLC Method [PDF]

Opioid drugs are common analgesics for managing chronic pain, but they have significant short- and long-term side effects. Despite this, opioid consumption continues to rise in high-income countries, raising concerns about dependency.
Andriani, Astuti, Puji, Novianry, Virhan
core   +1 more source

Mitragynine and morphine produce dose-dependent bimodal action on food but not water intake in rats.

Am J Physiol Regul Integr Comp Physiol
Novel compounds such as mitragynine, the primary alkaloid in kratom (Mitragyna Speciosa), have emerged as alternative self-treatments for opioid use disorder.
Zuarth Gonzalez JD, Mottinelli M, McCurdy CR, de Lartigue G, McMahon LR, Wilkerson JL.   +5 more
europepmc   +2 more sources

Kratom (Mitragyna speciosa): Medicinal Marvel or Menace? Assessing Potency, Risk, and Future Prospect of Herbal Medicine [PDF]

Kratom (Mitragyna speciosa) boasts a rich historical legacy as an herbal plant employed across generations for diverse therapeutic purposes, including pain relief, inflammation mitigation, anti-diarrheal effects, cough suppression, alleviation of fatigue,
Ni\u27ma, Neli Syahida
core   +1 more source

Mitragynin [PDF]

, 2019
openaire   +1 more source

生物試験 [PDF]

, 1995
村上 孝寿, 東田 道久, 松本 欣三, 渡辺 裕司   +3 more
core   +9 more sources