Non-conventional apoptotic response to ionising radiation mediated by N-methyl D-aspartate receptors in immature neuronal cells [PDF]
, 2013 During cortical development, N-methyl D-aspartate (NMDA) receptors are highly involved in neuronal maturation and synapse establishment. Their implication in the phenomenon of excitotoxicity has been extensively described in several neurodegenerative ...
Baatout, Sarah +5 more
core +2 more sources
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen +2 more
wiley +1 more source
Neural mechanisms of MK-801 induced sensitisation [PDF]
, 2016 Behavioural sensitisation describes the progressive and enduring augmentation of a drug-induced response that develops with repeated exposure. Sensitisation is a putative mechanism in the pathophysiology of drug addiction and neuropsychiatric disorders such as schizophrenia.
openaire +2 more sources
Interrupción del efecto de inhibición latente por la administración de Mk-801 [PDF]
, 2009 Los receptores -metil-D-aspartato (NMDA) parecen estar implicados en el retraso en la adquisición de una asociación pavloviana tras la preexposición sin consecuencias al que se va a convertir en estímulo condicionado, efecto al que se suele denominar
Casa Rivas, Luis Gonzalo de La +2 more
core
Role of the Calcium Plateau in the Neuronal Injury and Behavioral Morbidities Following Organophosphate Intoxication [PDF]
, 2016 Organophosphate (OP) chemicals include nerve agents and pesticides, and there is a growing concern of OP based chemical attacks against civilians. Current antidotes are essential in limiting immediate mortality associated with OP exposure.
Battaglia F.P. +8 more
core +2 more sources
Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co-Agonist Site [PDF]
, 2013 BACKGROUND: Stimulating the glycine(B) binding site on the N-methyl-D-aspartate receptor (NMDAR) has been proposed as a novel mechanism for modulating behavioral effects of ethanol (EtOH) that are mediated via the NMDAR, including acute intoxication ...
Atkinson +60 more
core +1 more source
Glutamate receptors within the lateral periaqueductal gray (lPAG): Effects on blood pressure and heart rate in basic and hypotensive hemorrhagic rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): The lateral periaqueductal gray (lPAG) is involved in regulating cardiovascular activity. As glutamate is present in this region, the effect of glutamatergic receptors on cardiovascular functions in basic and hypotensive hemorrhagic (Hem ...
Vida Alikhani +2 more
doaj +1 more source
SEX-SPECIFIC RESTORATION OF MK-801-INDUCED SENSORIMOTOR GATING DEFICIT BY ENVIRONMENTAL ENRICHMENT [PDF]
Despite ample evidence of N-methyl-D-aspartate (NMDA) receptor dysfunction in schizophrenia, no study has addressed the effects of enriched environment (EE) on sensorimotor gating deficits induced by postnatal NMDA receptor blockade. We evaluated the
ATAPOUR, N +4 more
core
Neurobiology of Disease, 2002 Cerebral ischemia activates ERK and Akt pathways. We studied whether these activations were affected by treatment with the protective growth factor transforming growth factor-α (TGF-α), and whether they were mediated through N-methyl d-aspartate (NMDA ...
Bibiana Friguls +4 more
doaj +1 more source
Synaptic NMDA receptors mediate hypoxic excitotoxic death [PDF]
, 2012 Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia.
Wroge, Christine M +3 more
core +1 more source