Results 81 to 90 of about 16,176 (222)

The role of NMDA receptors in rat propofol self-administration

BMC Anesthesiology, 2020
Background Propofol is among the most frequently used anesthetic agents, and it has the potential for abuse. The N-methyl-D-aspartate (NMDA) receptors are key mediators neural plasticity, neuronal development, addiction, and neurodegeneration.
Bei-ping Chen, Xi-xi Huang, Dong-mei Dong, Hui Wu, Tian-qi Zhu, Ben-fu Wang   +5 more
doaj   +1 more source

Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (noncompetitive NMDA receptor inhibitor), memantine (low‐affinity extrasynaptic‐NMDA ...
Motohiro Okada, Ruri Okubo, Tomoka Oka, Eishi Motomura   +3 more
wiley   +1 more source

Current status of multilayer neutron interferometry with gaseous samples at J‐PARC

Journal of Applied Crystallography, Volume 59, Issue 3, Page 799-803, June 2026.
First measurements of the neutron scattering lengths of 3He and 4He using a multilayer‐type neutron interferometer at J‐PARC are reported, demonstrating the initial feasibility of the method with prospects for improved precision.Several few‐body nuclear models, such as the Argonne v18 potential including three‐nucleon forces and chiral effective field ...
Taro Nambu, Clayton J. Auton, Takuhiro Fujiie, Masahiro Hino, Takuya Hosobata, Go Ichikawa, Masaaki Kitaguchi, Anna L. McElhannon, Kenji Mishima, Yoshichika Seki, Hirohiko M. Shimizu, William M. Snow, Yutaka Yamagata   +12 more
wiley   +1 more source

Effects of intracerebroventricular MK-801 administration on pERK and pNR1 in the SCN core and SON.

, 2013
A-C: Shown are representative images of pERK immunostaining in the SCN core from animals treated with vehicle (VEH), 8.9 mM MK-801, and 17.8 mM MK-801. Scale bar  =  100 µm.
Ian C. Webb (286588), Michael N. Lehman (286591), Lique M. Coolen (286590)   +2 more
core   +1 more source

NMDA receptors on parvalbumin-positive interneurons and pyramidal neurons both contribute to MK-801 induced gamma oscillatory disturbances: Complex relationships with behaviour

Neurobiology of Disease, 2020
Background: NMDAr antagonists induce disturbances to gamma frequency oscillations, including increasing ongoing gamma activity and reducing evoked gamma oscillations.
Matthew R. Hudson, Elysia Sokolenko, Terence J. O'Brien, Nigel C. Jones   +3 more
doaj   +1 more source

Mechanism‐Based Polypharmacy as a Repurposing Strategy: The Case of D‐Cycloserine and Lurasidone

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Modern psychiatric treatment often necessitates polypharmacy, yet combination regimens carry significant risks of metabolic burden and drug–drug interactions. There is growing interest in and clinical acceptance of rational, mechanism‐based drug combinations that are designed around desirable pharmacological properties rather than trial and ...
Avery D. Franzen, John S. Svendsen, Cassidy J. Kline, Susan Q. Shen   +3 more
wiley   +1 more source

Functional and molecular changes in the nucleus accumbens of MK-801-sensitized rats

, 2018
Behavioural sensitization is a putative mechanism in the pathophysiology of drug addiction and neuropsychiatric disorders such as schizophrenia. In rodents, drug-induced behavioural sensitization has been described for several different drug classes. The
Lefevre, Emilia, Darryl W. Eyles, Peter Josh, Gooch, Helen, Helen Gooch, Eyles, Darryl W., Alexander, Suzy, Emilia Lefevre, Suzy Alexander, Thomas H.J. Burne, Burne, Thomas H. J., Josh, Peter   +11 more
core   +1 more source

Conventional cigarettes, novel heated tobacco products, and self‐reported frequent headache association in Japanese individuals: Insights from the JASTIS study, a Japanese cross‐sectional analysis

Headache: The Journal of Head and Face Pain, Volume 66, Issue 6, Page 1317-1329, June 2026.
Plain Language Summary Headache is a common health problem, and tobacco products, such as conventional cigarettes and heated tobacco products (HTPs), may be associated with it. Using data from over 23,000 adults in the Japan Society and New Tobacco Internet Survey, we examined the relationships between cigarette and HTP use and self‐reported frequent ...
Masahito Katsuki, Kieran Moran, Muneto Tatsumoto, Keisuke Suzuki, Tomokazu Shimazu, Yasuhiko Matsumori, Yutaro Fuse, Miguel Á. Huerta, Daijiro Sugiyama, Jackson T. S. Cheung, Siobhán O'Connor, Tomás Ward, Takahiro Tabuchi   +12 more
wiley   +1 more source

Chemical structures of Memantine, Amantadine and MK-801.

, 2014
Chemical structures of Memantine, Amantadine and MK-801.
Lisvane Silva Paes (267021), Ariel Mariano Silber (167356), María Julia Barisón (528521), Elisabeth Mieko Furusho Pral (435602), Flávia Silva Damasceno (528520)   +4 more
core   +1 more source

Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment

, 2014
Adolescence is a critical period for neurodevelopment. MK-801 treatment and social isolation are important animal models for various neurodevelopmental disorders.
Wang, Weiwen, Shao, Feng, Li, Man, Du, Wei, Shao, Shuang   +4 more
core