Results 61 to 70 of about 16,176 (222)

Acute Administration of MK-801 in an Animal Model of Psychosis in Rats Interferes with Cognitively Demanding Forms of Behavioral Flexibility on a Rotating Arena

Frontiers in Behavioral Neuroscience, 2015
Patients with schizophrenia often manifest deficits in behavioral flexibility. Non-competitive NMDA receptor antagonists such as MK-801 induce schizophrenia-like symptoms in rodents, including cognitive functions.
Jan eSvoboda, Anna eStankova, Anna eStankova, Marie eEntlerova, Ales eStuchlik, Ales eStuchlik   +5 more
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, Volume 13, Issue 36, 29 June 2026.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Behavioural sensitisation to MK-801 is dose-dependent and independent of environmental context

, 2016
The pathophysiology of schizophrenia is associated with disturbed glutamate signalling, particularly via a dysfunction of the N-methyl- d-aspartate (NMDA) receptor.
Lefevre, Emilia M., Eyles, Darryl W., Burne, Thomas H. J.   +2 more
core   +1 more source

Disseminated Corticolimbic Neuronal Degeneration Induced in Rat Brain by MK-801: Potential Relevance to Alzheimer's Disease

Neurobiology of Disease, 1998
Blockade ofN-methyl-d-aspartate (NMDA) glutamate receptors by MK-801 induces neuronal degeneration in the posterior cingulate/retrosplenial cortex and other corticolimbic regions although damage in the latter has not been adequately characterized.
D.F. Wozniak, K. Dikranian, M.J. Ishimaru, A. Nardi, T.D. Corso, T. Tenkova, J.W. Olney, A.S. Fix   +7 more
doaj   +1 more source

Redirecting Alzheimer's disease therapeutics: Multitarget drugs and complementary non‐pharmacological strategies

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder driven by intersecting pathological processes. Persistent attrition in AD drug‐development pipelines highlights the limited clinical impact of single‐target therapies and has increased interest in multi‐target approaches acting on shared biological hubs.
Humberto Martínez‐Orozco, Jesús Andrade‐Guerrero, Nelly Jovana Pastén‐Castrejón, Chryslaine Rodríguez‐Tanty, Sofía Y Diaz‐Miranda   +4 more
wiley   +1 more source

Proteome analysis after co-administration of clozapine or haloperidol to MK-801-treated rats

, 2007
MK-801, a glutamergic, N-methyl-D-aspartate (NMDA)-receptor antagonist that mediates neurotransmission and has psychotomimetic properties, giving schizophrenia-like symptom.
Blennow, Kaj,, Ljung, E, Davidsson, Pia,, Martin, P, Paulson, Linda,   +4 more
core   +1 more source

Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801, [PDF]

, 1994
Chronic administration of a psychomotor stimulant has been shown to produce progressively enhanced effects, a phenomenon called "reverse tolerance" or sensitization.
Xiaojuan Xu,, Domino, Edward F.
core   +1 more source

Comparison of behavioural and molecular effects of two different schizophrenia models induced by subchronic MK-801 administration in rats

, 2018
Schizophrenia is a severe psychiatric disorder with about 1% prevalance. NMDA receptor antagonists such as Phencyclidine (PCP) and MK-801 are commonly used for modeling schizophrenia in rodents.
ARICIOĞLU, FEYZA
core   +2 more sources

Role of thalamic projection in NMDA receptor-induced disruption of cortical slow oscillation and short-term plasticity

Frontiers in Psychiatry, 2011
NMDA receptor (NMDAR) antagonists, such as phencyclidine, ketamine or dizocilpine (MK-801) are commonly used in psychiatric drug discovery in order to model several symptoms of schizophrenia, including psychosis and impairments in working memory.
Tamás eKiss, William E Hoffmann, Liam eScott, Thomas T Kawabe, Anthony J Milici, Erik A Nilsen, Mihály eHajós   +6 more
doaj   +1 more source

Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy

IBRO Reports, 2020
Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies.
Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara   +9 more
doaj   +1 more source