MARKETING ACTIVITIES DURING THE INNOVATION PROCESS: INTERACTION OF RESEARCH AND DEVELOPMENT [PDF]
, 2012 According to the aberrant-salience hypothesis, attribution of motivational salience is severely disrupted in patients with schizophrenia. To provide a translational approach for investigating underlying mechanisms, neural correlates of salience ...
Habel, Ute +3 more
core +1 more source
Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior [PDF]
, 2016 Current antipsychotics are effective in treating the positive symptoms associated with schizophrenia, but they remain suboptimal in targeting cognitive dysfunction.
Arthur Christopoulos +14 more
core +1 more source
MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis
Neural Regeneration Research, 2019 Objective: To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury. Data Sources: Key terms were “stroke”, “brain diseases”, “brain injuries”, “brain hemorrhage, traumatic”, “acute brain injury”, “
Nan-Xing Yi +10 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 Schizophrenia is a group of severe mental disorders. MiR-25-3p was shown to be involved in various neuropsychiatric diseases and can regulate SIK1 and TWIST1.
Bo Pan +11 more
doaj +1 more source
MK-801 Impairs Cognitive Coordination on a Rotating Arena (Carousel) and Contextual Specificity of Hippocampal Immediate-Early Gene Expression in a Rat Model of Psychosis [PDF]
, 2014 Flexible behavior in dynamic, real-world environments requires more than static spatial learning and memory. Discordant and unstable cues must be organized in coherent subsets to give rise to meaningful spatial representations.
AleÅ¡ StuchlÃk +3 more
core +2 more sources
Incomplete block of NMDA receptors by intracellular MK-801 [PDF]
Neuropharmacology, 2018 NMDA receptors (NMDARs) are essential components in glutamatergic synaptic signaling. The NMDAR antagonist MK-801 has been a valuable pharmacological tool in evaluating NMDAR function because it binds with high affinity to the NMDAR ion channel pore and is non-competitive with ligand binding.
Sun, Weinan +3 more
openaire +6 more sources
Journal of Experimental Neuroscience, 2015 The present study was designed to investigate the effect of once daily for 7-day (subchronic treatment) dosing of histamine H 3 receptor antagonists, ciproxifan (CPX) (3 mg/kg, i.p.), and clobenpropit (CBP) (15 mg/kg, i.p), including clozapine (CLZ) (3.0
D. Mahmood +5 more
doaj +1 more source
Decreased MK-801 Binding in Discrete Hippocampal Regions of Prion-Infected Mice
Neurobiology of Disease, 2001 The neurochemical alterations associated with neurodegeneration in prion diseases are not well defined. It is therefore of interest to study the influence of prion infection on messenger molecules and their receptors.
M. Diez +4 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2021 The neonatal MK-801 model of schizophrenia has been developed based on the neurodevelopmental and NMDA receptor hypofunction hypotheses of schizophrenia.
Maria E. Plataki +9 more
doaj +1 more source
Differences in trait impulsivity do not bias the response to pharmacological drug challenge in the rat five-choice serial reaction time task. [PDF]
, 2018 RATIONALE: Maladaptive impulsivity is symptomatic of several neuropsychiatric disorders including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and substance abuse disorders; paradigms designed to assess the underlying neurobiology of ...
Barlow, Rebecca L +2 more
core +1 more source