Results 51 to 60 of about 24,407 (221)
Frontiers in Pharmacology, 2013 Antagonism of N-methyl-D-aspartate (NMDA) receptors by phencyclidine is thought to underlie its ability to induce a schizophrenia-like syndrome in humans, yet evidence indicates it has a broader pharmacological profile.
Wendy K Adams +3 more
doaj +1 more source
Protective effect of resveratrol on kidney and liver histopathology induced by nmda receptor antagonist mk-801 in mice [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019 TMK-801 is an antagonist of N-methyl-D-aspartate (NMDA) receptors. Sub-chronic administration of 1 mg / kg dose of MK-801 resulted in schizophrenia-like symptoms and degeneration in the brain of mice.
Murat Sırrı AKOSMAN +2 more
doaj +1 more source
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2015 As a multifactorial disease, the underlying causes of schizophrenia require analysis by multiplex methods such as proteomics to allow identification of whole protein networks.
Paul C Guest +6 more
doaj +1 more source
Pharmacological blockade of serotonin 5-HT₇ receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission. [PDF]
PLoS ONE, 2011 The role of 5-HT₇ receptor has been demonstrated in various animal models of mood disorders; however its function in cognition remains largely speculative.
Pascal Bonaventure +7 more
doaj +1 more source
The effect of MK-801 on openfield activities and object exploration and its sex difference [PDF]
, 1998 The present study investigated the effect of MK-801 on openfield activities and object exploratory behavior in a circular openfield by using Sprague-Dawley rats.
Kishida Akemi +3 more
core +1 more source
Involvement of Glutamate NMDA Receptors in the Acute, Long-Term, and Conditioned Effects of Amphetamine on Rat 50kHz Ultrasonic Vocalizations [PDF]
, 2015 BACKGROUND: Rats emit 50kHz ultrasonic vocalizations (USVs) in response to either natural or pharmacological pleasurable stimuli, and these USVs have emerged as a new behavioral measure for investigating the motivational properties of drugs.
COSTA G, MORELLI M, SIMOLA N
core +1 more source
Journal of Applied Polymer Science, EarlyView.This study develops an interpretable machine‐learning framework to predict multiple properties of polymer composites based on composition and processing variables. By combining ensemble models with composition‐based feature generation and SHAP‐based interpretation, the approach reveals composition‐property relationships and supports efficient multi ...
Dong Ryeol Shin, Sung Kwang Lee
wiley +1 more source
NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice [PDF]
, 2016 Experiencing psychosocial stress inearly life, suchas social isolationstress (SIS), is knowntohavenegative enduring effects on the development of the brain and behavior.
Amini-Khoei, Hossein. +10 more
core +1 more source
Arthritis &Rheumatology, Accepted Article.Objectives The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in non‐lymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi +9 more
wiley +1 more source