Results 51 to 60 of about 16,176 (222)

Memantine prevents acute stress‐induced memory deficits by reversing sex‐dependent pathophysiological glutamatergic alterations in the dorsal hippocampus

British Journal of Pharmacology, Volume 183, Issue 16, Page 4939-4952, August 2026.
Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi, Lidia Diolosà, Giuseppe Aceto, Claudia Marchetti, Federica Geraci, Konstantinos Partsinevelos, Silvia Rizzo, Margherita Grasso, Filippo Caraci, Francesco Bellia, Giovanni Li Volti, Angela Maria Amorini, Marcello D′Ascenzo, Gian Marco Leggio   +13 more
wiley   +1 more source

Administração de MK-801 e CNQX na área hipotalâmica lateral e tubérculo olfativo e seus efeitos sobre a ingestão de alimentos em pombos (Columba livia) [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências BiológicasO presente trabalho teve como objetivo examinar os efeitos dos antagonistas de receptores glutamatérgicos ionotrópicos NMDA e AMPA-kainato sobre o consumo de ...
Silva, Amanda Alcaraz da
core  

Olanzapine Reverses MK-801-Induced Cognitive Deficits and Region-Specific Alterations of NMDA Receptor Subunits

Frontiers in Behavioral Neuroscience, 2018
Cognitive dysfunction constitutes an essential component in schizophrenia for its early presence in the pathophysiology of the disease and close relatedness to life quality of patients.
Xiao Liu, Xiao Liu, Xiao Liu, Jitao Li, Chunmei Guo, Hongli Wang, Yaxin Sun, Han Wang, Yun-Ai Su, Keqing Li, Keqing Li, Tianmei Si   +11 more
doaj   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, Volume 28, Issue 13, 8 July 2026.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

Effect of MK-801 and clozapine on the proteome of cultured human oligodendrocytes

Frontiers in Cellular Neuroscience, 2016
Separate lines of evidence have demonstrated the involvement of NMDA receptor and oligodendrocyte dysfunctions in schizophrenia. Here we have carried out shotgun mass spectrometry proteome analysis of oligodendrocytes treated with the NMDA receptor ...
Juliana Silva Cassoli, Keiko eIwata, Johann eSteiner, Paul C. Guest, Christoph W Turck, Juliana Minardi Nascimento, Juliana Minardi Nascimento, Daniel eMartins-de-Souza, Daniel eMartins-de-Souza   +8 more
doaj   +1 more source

Acetylcholinesterase Inhibition and Protection by Dizocilpine (MK−801) Enantiomers

Journal of Pharmacy and Pharmacology, 1996
AbstractThe optical isomers of the N-methyl-d-aspartate (NMDA) receptor ion-channel blocker dizocilpine (MK−801) were shown to interact with electric eel and rat brain acetylcholinesterase (AChE) in a mixed competitive-noncompetitive way. The (-) form, pharmacologically less active, was the most potent of the two isomers as an AChE inhibitor (K1 for ...
A, Galli, F, Mori
openaire   +2 more sources

Prediction of Properties of Polymer Composite Formulations Using Ensemble Models With Feature Generation

Journal of Applied Polymer Science, Volume 143, Issue 25, July 5, 2026.
This study develops an interpretable machine‐learning framework to predict multiple properties of polymer composites based on composition and processing variables. By combining ensemble models with composition‐based feature generation and SHAP‐based interpretation, the approach reveals composition‐property relationships and supports efficient multi ...
Dong Ryeol Shin, Sung Kwang Lee
wiley   +1 more source

Systemic administration of mk-801 protects against in perinatal rats

, 1990
MK-801, a non-competitive antagonist of glutamate receptors, was tested for its ability to antagonize excitotoxic actions of or quisqualic acid injected into the brains of seven-day-old rats.
Hudson, C., Silverstein, Faye Sarah, McDonald, John W., Chen, Ronni, Cardona, Daniel., Johnston, Michael V.   +5 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Effects of SB-269970 on MK-801-induced DNMTP deficits.

, 2013
SB-269970 (10 mg/kg) and MK-801 (0.1 mg/kg), or their vehicles, were co-administered 10 min before the beginning of the session (N = 6 per group).
Leah Aluisio (349456), James Shoblock (333537), Ian C. Fraser (349458), Ruggero Galici (349461), Pascal Bonaventure (333540), Jamin D. Boggs (349457), Brian Lord (349459), Timothy W. Lovenberg (349460)   +7 more
core   +1 more source