Results 161 to 170 of about 24,579 (198)

MK-801-induced and scopolamine-induced hyperactivity in rats neonatally treated chronically with MK-801

Behavioural Pharmacology, 2013
This study investigated the effects of chronic neonatal blockade of N-methyl-D-aspartate (NMDA) receptors on NMDA and muscarinic acetylcholine receptor-mediated neurotransmission in adulthood. Rats neonatally treated chronically with MK-801/saline were tested for 40 min, at the age of 14-16 weeks, for locomotor activity in an open field immediately ...
Hiroki, Furuie, Kazuo, Yamada, Yukio, Ichitani   +2 more
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[3H]MK-801 binding in Alzheimer's disease

Neuroscience Letters, 1988
The density of [3H]MK-801 binding sites was studied in homogenates prepared from different cortical regions of postmortem brains of Alzheimer patients and age matched controls. Highest number of binding sites for this noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor was in temporal pole (Brodmann area A-38) in both groups.
M M, Mouradian, P C, Contreras, J B, Monahan, T N, Chase   +3 more
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MK-801-induced neuronal damage in rats

Brain Research, 1997
The non-competitive N-methyl-D-aspartate antagonist MK-801 has been frequently used to attenuate neurotoxicity mediated by excessive release of glutamate. However, doses of MK-801, effective to prevent cell loss in some areas have been reported to induce pathological changes in retrosplenial cortex [32].
Z C, Horváth, J, Czopf, G, Buzsáki
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Bupivacaine-Induced Convulsion is Suppressed by MK-801

Regional Anesthesia & Pain Medicine, 1998
Background and Objectives Not only the facilitation of inhibitory synapses but also the suppression of excitatory synapses may be effective in treating convulsion induced by local anesthetics. The effects of MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist, on bupivacaine-induced convulsion and hemodynamic ...
T, Kasaba, S, Shiraishi, M, Taniguchi, M, Takasaki   +3 more
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Ameliorative Effect of MK-801 on Retinal Ischemia

Journal of Ocular Pharmacology and Therapeutics, 1997
The efficacy of MK-801, an N-methyl-D-aspartate receptor antagonist, was evaluated in a rat model of retinal ischemia induced by elevated intraocular pressure. Intraperitoneal injection of MK-801 at 0, 1, 3 and 10 mg/kg was given immediately after reperfusion.
T T, Lam, E, Siew, R, Chu, M O, Tso
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Behavioral effects of MK-801 in the rat

Psychopharmacology, 1990
Several experiments were conducted to study the effects of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on learning and memory in the rat. Rats displayed impaired performance on several sensorimotor tests and appeared grossly intoxicated when treated IP with 0.2 mg/kg MK-801, but not when treated with lower doses (0.05 or
D F, Wozniak, J W, Olney, L, Kettinger, M, Price, J P, Miller   +4 more
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In Vitro Cerebral Vasoactive Effects of MK-801

Journal of Neurosurgical Anesthesiology, 1995
MK-801, although more consistently neuroprotective in focal ischemia, has had more variable success in the management of global ischemia. This difference could be due to a vasoactive effect that would improve blood flow in focal ischemia but would not be operative in global ischemia.
A W, Gelb, C, Zhang, J T, Hamilton
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Neuroprotection by MK-801 in temperature maintained gerbils

Brain Research Bulletin, 1995
Hypothermia reduces ischemic brain damage, confounding interpretation of the neuroprotective effects of drugs. Specifically, the neuroprotectant MK-801 has been shown to cause hypothermia. Some have claimed that when body temperature is maintained, MK-801 is not a neuroprotectant, whereas others claim it retains its neuroprotective activity. MK-801 was
C A, Hoffman, C A, Boast
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Amnesic effect of the novel anticonvulsant MK-801

Pharmacology Biochemistry and Behavior, 1988
MK-801, a reported N-methyl-D-aspartate (NMDA) antagonist with affinity for the phencyclidine (PCP) receptor, injected intravenously in mice before a training trial in a passive avoidance procedure, produced a similar amnesic effect to that produced by the standard amnesic agent scopolamine.
M J, Benvenga, T C, Spaulding
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Paradoxical effects of very low dose MK-801

European Journal of Pharmacology, 2006
Systemic injection of the noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine maleate) is known to cause increased locomotion and various stereotypic behaviors in rodents. However, the MK-801 dose ranges commonly examined usually begin at tenth of mg/kg and going higher, with the implicit assumption of lower doses being ...
Yuanjia, Tang, Hong, Zou, Judith A, Strong, Yiwen, Cui, Qinglian, Xie, Guoping, Zhao, Meilei, Jin, Lei, Yu   +7 more
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