Results 171 to 180 of about 24,579 (198)

MK‐801 inhibition of nicotinic acetylcholine receptor channels

Synapse, 1991
AbstractMK‐801 is a potent inhibitor of the NMDA subtype of glutamate receptors. Single‐channel and macroscopic current indicate that MK‐801 also inhibits nicotinic acetylcholine receptors (nAChRs). MK‐801 does not significantly increase desensitization of the nAChR, the main action of MK‐801 is to enter and block the open channel.
M, Amador, J A, Dani
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MK-801 and NBQX prevent electrically induced status epilepticus

NeuroReport, 1994
MUSCARINIC, NMDA and metabotropic glutamate receptor antagonists were tested for anticonvulsant effects in a continuous hippocampal stimulation model in rats in order to identify the receptors involved in the initiation of electrically induced status epilepticus (SE).
D, Young, M, Dragunow
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MK-801 decreases striatal and cortical GAD65 mRNA levels

NeuroReport, 1995
Levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors of the dorsal striatum.
N, Laprade, J J, Soghomonian
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Enhanced MK-801-induced locomotion in Kir6.2 knockout mice

Neuroscience Research, 2012
ATP-sensitive K(+) (K-ATP) channels provide a unique link between cellular energetics and electrical excitability, and also act as a unifying molecular coordinator of the body's response to stress. Although the body's response to stress is implicated in the worsening or relapse of psychotic symptoms in schizophrenia, the role of K-ATP channels remains ...
Yan, Zhou, Meng-Di, Liu, Yi, Fan, Jian-Hua, Ding, Ren-Hong, Du, Gang, Hu   +5 more
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MK-801 Limits Neurovascular Dysfunction during Experimental Allergic Encephalomyelitis

The Journal of Pharmacology and Experimental Therapeutics, 1997
Increased permeability of the blood-brain barrier (BBB) is a characteristic of the demyelinating disease multiple sclerosis and the animal counterpart experimental allergic encephalomyelitis (EAE). In physically traumatized cerebral tissue neurovascular damage, linked with activation of the cerebroendothelial-bound N-methyl-D-aspartate receptor, can be
C, Bolton, C, Paul
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MK-801 Protects against Carbon Monoxide-Induced Hearing Loss

Toxicology and Applied Pharmacology, 1995
MK-801, a glutamate receptor blocker, has been reported to protect against hypoxic-ischemic neuronal degeneration. The purpose of this study was to investigate the protective effects of MK-801 on cochlear impairment induced by carbon monoxide (CO) in the guinea pig and whether the protection reflected systemic or local effects.
Y, Liu, L D, Fechter
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The discriminative stimulus effects of MK-801 in pigeons

Behavioural Pharmacology, 1991
The discriminative stimulus effects of MK-801 [(+)-5-methyl-10, 11-dihydroxy-5H-dibenzo (a,d) cyclohepten-5, 10-imine], a proposed noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were studied in pigeons discriminating MK-801 from saline, responding being maintained by food.
E.R., Butelman, C.P., France, J.H., Woods   +2 more
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MK-801 Interferes with Nutrient-related Signals for Satiation

Appetite, 1998
Abstract We previously reported that MK-801, a non-competitive N -methyl- d -aspartate (NMDA) receptor antagonist, increased food intake by rats. Increased intake occurred only when deprivation or presentation of a highly preferred food had initiated feeding. MK-801 did not cause initiation of food intake.
G A, Burns, L G, Fleischmann, R C, Ritter   +2 more
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Acute behavioral effects of MK-801 in the mouse

Pharmacology Biochemistry and Behavior, 1996
The acute effects of 0.05 mg/kg MK-801 on spatial learning and memory in male mice were studied using a modified hole board food search task. Dose-response sensorimotor and activity tests suggested that this dose of MK-801 did not induce significant nonassociative effects.
G, Brosnan-Watters, D F, Wozniak, A, Nardi, J W, Olney   +3 more
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Dizocilpine (MK-801) in Cerebral Ischemia

1992
Dizocilpine maleate (MK-801) is a drug with potential use in cerebral ischemia. However, controversy concerns its effectiveness in various ischemic settings, and the acceptability of side effects and potential toxicity. This article will review data from our laboratory and from the literature, amalgamating the existing evidence and pointing to ...
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