Results 181 to 190 of about 24,579 (198)

MK-801 enhances noradrenergic neurotransmission in rat vas deferens

European Journal of Pharmacology, 1996
The effect of MK-801 (dizocilpine) on the noradrenergic neurotransmission of the epididymal portion of rat vas deferens has been investigated. This drug potentiated the electrically induced responses (46.6% +/- 5.09 at a concentration of 3.7 microM) and the contractile effect of exogenous noradrenaline with a concentration-dependent reduction of EC50 ...
D, Pubill, A M, Canudas, D, Gasulla, M, Pallàs, E, Escubedo, J, Camarasa   +5 more
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Sex differences in dizocilpine (MK-801) neurotoxicity in rats

Environmental Toxicology and Pharmacology, 1999
The sex differences in the clinical signs and the distribution of astrocytic glial fibrillary acidic protein (GFAP) induced by an N-methyl-d-aspartate antagonist, dizocilpine (MK-801), were examined. A single intraperitoneal injection of MK-801 (5 mg/kg body weight) caused a prolonged recumbency (35-40 h), leading to a severe loss of body weight in ...
G H, Hur, W C, Son, S, Shin, J K, Kang, Y B, Kim   +4 more
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[3H]MK-801 binding sites in neonate rat brain

Brain Research, 1989
[3H]MK-801 binding sites are present in neonate rat brain as early as 3 days after birth. Immature hippocampus and cortex contain approximately one sixth the concentration of binding sites of the adult, while brainstem concentration is twice as high as that of adult. [3H]MK-801 binding is stimulated by glutamate and glycine and blocked by phencyclidine
A M, Morin, H, Hattori, C G, Wasterlain, D, Thomson   +3 more
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MK-801 reduced cerebral ischemic injury by inducing hypothermia

Brain Research, 1990
The non-competitive N-methyl-D-aspartate (NMDA) antagonist, MK-801, has been reported to prevent or attenuate ischemic brain damage in various animal models. In halothane-anesthetized gerbils it was found that an optimal dose of MK-801 (3.0 mg/kg) for providing cerebral protection also produced hypothermia (31.1 +/- 0.62 degrees C) relative to control ...
D, Corbett, S, Evans, C, Thomas, D, Wang, R A, Jonas   +4 more
openaire   +2 more sources

Postnatal lead exposure and MK-801 sensitivity.

Neurotoxicology, 1997
Postweaning Pb exposure has been associated with subsensitivity to the stimulus properties of the non-competitive NMDA receptor complex antagonist MK-801 (Cory-Slechta, 1995a). This study sought to determine whether Pb exposures occurring postnatally, i.e., during the primary period of development of many NMDA receptor subunits, would alter the nature ...
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MK-801 induces a low intensity conditioned taste aversion

Pharmacology Biochemistry and Behavior, 2012
N-methyl-D-aspartate (NMDA) receptor antagonists are often used to assess the role of NMDA receptors in learning and memory processes. However, few studies have explored the possibility that the antagonists may induce a conditioned aversion when administered following flavor consumption.
Luis M, Traverso, Gabriel, Ruiz, Luis G, De la Casa   +2 more
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MK-801 potently inhibits alcohol withdrawal seizures in rats

European Journal of Pharmacology, 1990
The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing.
R A, Morrisett, A H, Rezvani, D, Overstreet, D S, Janowsky, W A, Wilson, H S, Swartzwelder   +5 more
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MK-801 powerfully protects against N-methyl aspartate neurotoxicity

European Journal of Pharmacology, 1987
Using the ex vivo chick embryo retina to study the efficacy of antagonists in blocking the excitotoxic effects of excitatory amino acid agonists, we previously identified phencyclidine as the most powerful known anti-excitotoxin. Here we show that MK-801 is 5 times more powerful than phencyclidine as an anti-excitotoxin, that its antagonism is specific
J, Olney, M, Price, K S, Salles, J, Labruyere, G, Frierdich   +4 more
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MK-801

Drugs of the Future, 1983
J. Castañer, P.J. Thorpe
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MK-801-induced dystonia in cebus monkeys.

Clinical neuropharmacology, 1999
MK-801 (dizocilpine), a noncompetitive N-methyl-D-aspartate antagonist, induces dystonia in monkeys at doses of 0.08 mg/kg. This syndrome was tested with the dopamine D1 receptor antagonist NNC 756, the DA D2 receptor antagonist raclopride, the atypical antipsychotic clozapine, the dopamine D1 receptor agonist SKF 81297, the dopamine D2/D3 receptor ...
M, Madsen, H, Lublin
openaire   +1 more source