Neurobehavioral Differences of Valproate and Risperidone on MK-801 Inducing Acute Hyperlocomotion in Mice [PDF]
Behavioural Neurology, 2022 Objective. The glutamate system plays a major role in the development of neuropsychiatric disorders such as addiction, epilepsy, dementia, and psychosis.
Po-An Chen +4 more
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Effects of haloperidol inhalation on MK-801- and memantine-induced locomotion in mice [PDF]
Libyan Journal of Medicine, 2020 The administration of therapeutic agents is difficult in many patients, such as patients with post-operative delirium or dementia or patients with schizophrenia, who are upset in an emergency room.
Hiroshi Ueno +8 more
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Effect of MK-801, an antagonist of NMDA receptor in the pedunculopontine tegmental nucleus, on cardiovascular parameters in normotensive and hydralazine hypotensive rats [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): In the present study, the cardiovascular effects of glutamate NMDA receptor of the pedunculopontine tegmental nucleus (PPT) in normotensive and hydralazine (HLZ) hypotensive rats were evaluated.
Mohammad Reza Hosseiniravesh +5 more
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α2 Adrenergic Agonists Prevent MK-801 Neurotoxicity [PDF]
Neuropsychopharmacology, 1995 Antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor are of considerable interest for various neurotherapeutic purposes, including preventing neuronal degeneration in stroke and CNS trauma, suppressing neuropathic pain and preventing the development of tolerance to opiate analgesics.
N B, Farber +3 more
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Effect of the glucocorticoid receptor antagonist RU486 on MK-801 induced behavioural sensitisation. [PDF]
PLoS ONE, 2017 Stress is known to modulate sensitisation to repeated psychostimulant exposure. However, there is no direct evidence linking glucocorticoids and sensitisation achieved by repeated administration of the NMDA receptor antagonist MK-801.
Emilia M Lefevre +5 more
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Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model [PDF]
International Journal of Neuropsychopharmacology, 2016 Current data on antidepressant action of the N-methyl-D-aspartate receptor antagonist, (+)-MK-801, is inconsistent. This study was conducted to examine the effects of (+)-MK-801 and its less potent stereoisomer, (-)-MK-801, in the social defeat stress model of depression.The antidepressant effects of (+)-MK-801 (0.1mg/kg) and (-)-MK-801 (0.1mg/kg) in ...
Yang, Bangkun +4 more
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Frontiers in Cellular Neuroscience, 2021 Dizocilpine (MK-801), a non-competitive N-methyl-D-aspartic acid receptor (NMDA-R) antagonist, can induce schizophrenia-like symptoms in healthy individuals, implicating NMDA-R hypofunction in disease pathogenesis. Brain-derived neurotrophic factor (BDNF)
Wenjuan Yu +8 more
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Frontiers in Psychiatry, 2020 BackgroundIn neonatal rats, MK-801 treatment generates schizophrenia-like symptoms. Resveratrol (RSV) is a phenolic compound and a potent neuroprotective agent.
Juan Niu, Yuquan Cao, Yongjuan Ji
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Intra-accumbens injection of a dopamine aptamer abates MK-801-induced cognitive dysfunction in a model of schizophrenia. [PDF]
PLoS ONE, 2011 Systemic administration of the noncompetitive NMDA-receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia.
Matthew R Holahan +4 more
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Comprehensive Psychiatry, 2020 Background: In neonatal rats, MK-801 treatments can produce schizophrenia-like symptoms. Crocin is a water soluble carotenoid in Saffron that exerts potent neuroprotective effects.
Xi-juan Sun +3 more
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