Results 11 to 20 of about 16,176 (222)
Effect of the glucocorticoid receptor antagonist RU486 on MK-801 induced behavioural sensitisation. [PDF]
PLoS ONE, 2017 Stress is known to modulate sensitisation to repeated psychostimulant exposure. However, there is no direct evidence linking glucocorticoids and sensitisation achieved by repeated administration of the NMDA receptor antagonist MK-801.
Emilia M Lefevre +5 more
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Hydrogen Gas Therapy in Schizophrenia: Potential Neuroprotective Effects From an Animal Study
Neuropsychopharmacology ReportsAims Oxidative stress has recently emerged as a key factor in the pathophysiology of schizophrenia. This study investigated whether inhalation therapy with hydrogen gas, a selective antioxidant, could reduce oxidative stress and improve behavioral ...
Nobumi Miyake +5 more
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Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model [PDF]
International Journal of Neuropsychopharmacology, 2016 Current data on antidepressant action of the N-methyl-D-aspartate receptor antagonist, (+)-MK-801, is inconsistent. This study was conducted to examine the effects of (+)-MK-801 and its less potent stereoisomer, (-)-MK-801, in the social defeat stress model of depression.The antidepressant effects of (+)-MK-801 (0.1mg/kg) and (-)-MK-801 (0.1mg/kg) in ...
Yang, Bangkun +4 more
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Frontiers in Cellular Neuroscience, 2021 Dizocilpine (MK-801), a non-competitive N-methyl-D-aspartic acid receptor (NMDA-R) antagonist, can induce schizophrenia-like symptoms in healthy individuals, implicating NMDA-R hypofunction in disease pathogenesis. Brain-derived neurotrophic factor (BDNF)
Wenjuan Yu +8 more
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Frontiers in Psychiatry, 2020 BackgroundIn neonatal rats, MK-801 treatment generates schizophrenia-like symptoms. Resveratrol (RSV) is a phenolic compound and a potent neuroprotective agent.
Juan Niu, Yuquan Cao, Yongjuan Ji
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Intra-accumbens injection of a dopamine aptamer abates MK-801-induced cognitive dysfunction in a model of schizophrenia. [PDF]
PLoS ONE, 2011 Systemic administration of the noncompetitive NMDA-receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia.
Matthew R Holahan +4 more
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MK-801 is a potent nematocidal agent. Characterization of MK-801 binding sites in Caenorhabditis elegans [PDF]
Biochemical Journal, 1989 MK-801, an N-methyl-D-aspartate antagonist in mammalian brain tissue, is a potent nematocidal agent. Specific MK-801 binding sites have been identified and characterized in a membrane fraction prepared from the free-living nematode Caenorhabditis elegans. The high-affinity MK-801 binding site has an apparent dissociation constant, Kd, of 225 nM. Unlike
J M, Schaeffer +2 more
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Comprehensive Psychiatry, 2020 Background: In neonatal rats, MK-801 treatments can produce schizophrenia-like symptoms. Crocin is a water soluble carotenoid in Saffron that exerts potent neuroprotective effects.
Xi-juan Sun +3 more
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Convergent Strategy to Dizocilpine MK-801 and Derivatives [PDF]
The Journal of Organic Chemistry, 2018 A convergent total synthesis of MK-801 has been achieved. Key synthetic transformations include a multicomponent Barbier-type reaction to construct the α-branched amine, a selective Heck α-coupling tactic to generate the exocyclic alkene skeleton, and a late-stage intramolecular hydroamination reaction between the exocyclic alkene and the secondary ...
Vardhan Reddy, K. Harsha +4 more
openaire +3 more sources
Frontiers in Pharmacology, 2015 Dizocilpine (MK-801) is a noncompetitive NMDA antagonist that induces schizophrenic-like effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents.
Patricia G Saletti +5 more
doaj +1 more source